2nd “Protein-DNA Interactions: from Biophysics to Cancer Biology” Workshop
Day 1: Thursday, December 5, 2019
Reception and Breakfast 7:00 – 8:20am
Opening Remarks Anatoly Kolomeisky 8:20 – 8:30am
Session 1. Cancer-relevant protein-DNA interactions Chair: Guang Peng
1-1. Ben E. Black (University of Pennsylvania) 8:30 – 9:00am
Structural basis for allosteric PARP-1 DNA break retention and release
1-2. Chin-Yo Lin (Univ. of Houston) 9:00 – 9:30am
Mapping and Modeling Estrogen Receptor Binding Sites: Basic Mechanisms and Relevance to Breast Cancer Biology
1-3. Weixing Zhao (Univ. of Texas HSC San Antonio) 9:30 – 10:00am
Deciphering the DNA Binding Activities of BRCA1/2 in Genome Maintenance and Tumor Suppression
Session 2. Protein/DNA dynamics (I) Chair: Junji Iwahara
2-1. Peter Wolynes (Rice University) 10:20 – 10:50am
Protein-DNA Energy Landscapes from Transcription Factors to Chromosomes
2-2. Ralf Metzler (University of Potsdam) 10:50 – 11:20am
Geometry- and reaction-controlled diffusive search in gene regulation
2-3. B. Montgometry Pettitt (Univ. of Texas Medical Branch) 11:20 – 11:50am
DNA Confined
Poster graphical abstract presentations
11:50 – 12:15pm
Lunch Break & Poster Session 1 12:15 – 1:30pm
Session 3. Chromatin biology, epigenetics, and cancer Chair: Courtney Hodges
3-1. Alistair Boettiger (Stanford University) 1:40 – 2:10pm
Highly multiplexed super-resolution imaging of chromatin structure
3-2. Nicolas Young (Baylor College of Medicine) 2:10 – 2:40pm
Single Molecule Combinations of Histone Post-translational Modifications Dynamically Regulate the Genome
3-3. Wei Li (Baylor College of Medicine) 2:40 – 3:10pm
Homeobox Oncogene Activation by Pan-Cancer DNA Hypermethylation
Break
3-4. Lacramioara Bintu (Stanford University) 3:30 – 4:00pm
Controlling and measuring epigenetic regulation dynamics
3-5. Stephen Mack (Baylor College of Medicine) 4:00 – 4:30pm
Endogenous Retroviral Element Activation in Oncohistone Mutated Glioma
3-6. Xiaodong Cheng (MD Anderson Cancer Center) 4:30 – 5:00pm
Detection of DNA modifications by sequence-specific transcription factors
Day 2: Friday, December 6, 2019
Breakfast 7:30 – 8:20am
Session 4. Protein/DNA dynamics (II) Chair: Anatoly Kolomeisky
4-1. José Nelson Onuchic (Rice University) 8:30 – 9:00am
Protein sequence coevolution, energy landscapes and their connections to protein structure, folding and function
4-2. Yuri Lyubchenko (University of Nebraska) 9:00 – 9:30am
AFM to Directly Visualize Dynamics of protein-DNA complexes
4-3. Margaret Cheung (University of Houston) 9:30 – 10:00am
Proteins in a crowd under heat and pressure
Break
4-4. Marc C. Morais (Univ. of Texas Medical Branch) 10:20 – 10:50am
Mechanistic Implications of Symmetry Breaking in Viral dsDNA Packaging Motors
4-5. Michael Diehl (Rice University) 10:50 – 11:20am
Demultiplexing the Multiple Overlapping Functions of Scaffold Proteins
4-6. Oleg Igoshin (Rice University) 11:20 – 11:50am
Understanding Trade-offs in Biological Error Correction
Lunch & Poster Session 2 11:50 – 1:00pm
Session 5. Transcription factors Chair: Chin-Yo Lin
5-1. Charles Lin (Baylor College of Medicine) 1:10 – 1:40pm
Targeting master transcription factor dependency in cancer
5-2. Peter Vekilov (University of Houston) 1:40 – 2:10pm
Unique Aggregation Behaviors of the Wild Type and Mutant Variants of the Transcription Factor p53
Break
5-3. Polly Fordyce (Stanford University) 2:30 – 3:00pm
Leveraging Microfluidics for High-Throughput Studies of Transcription Factor/DNA Binding
5-4. Elizabeth Komives (University of California San Diego) 3:00 – 3:30pm
The functional fuzziness of the NFκB transcription activation domain
Poster awards 3:30 – 3:40pm
Keynote Presentation (Keck seminar) [web-broadcasted] Introduction: Chin-Yo Lin
Dr. Gordon Hager (National Cancer Institute) 4:00 – 5:00pm
New emergent properties of transcription factor dynamics in the mammalian nucleus
Closing Remarks Anatoly Kolomeisky 5:00 – 5:15pm