FacultyHeader
Tapas Hazra, PhD
Tapas Hazra, PhD
Professor

Scientist, Sealy Center for Molecular Medicine

Division: Pulmonary Critical Care & Sleep Medicine
Department: Internal Medicine

Research Interests
  • Oxidative damage repair in mammalian genomes
  • Enzyme kinetics, biochemical and cellular characterization of protein-protein and protein-DNA interactions
  • Post-translational modification of DNA repair proteins, SNP analysis, mutation analysis, transcription-coupled repair of oxidized bases, DNA repair and inflammation: linkage to disease susceptibility.
Clinical Interests
  • Lung Diseases
Publications
  1. Hazra, TK; Izumi, T.; Boldogh, I.; Imhoff, B.; Kow, Y. W.; Jaruga, P., Dizdaroglu, M. and Mitra S. Identification and characterization of a human DNA glycosylase for repair in modified bases in oxidatively damaged DNA. Proc. Natl. Acad. Sci. 99:3523-3528, 2002. PMID: 11904416. PMCID: PMC122556Â
  2. Dou, H., Mitra, S., and Hazra,TK. Repair of oxidized bases from DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. J. Biol. Chem. 278:49679-49684, 2003. PMID: 14522990
  3. Wiederhold, L., Leppard JB., Kedar P.,Karimi-Busheri F., Rasouli-Nia, A., Weinfeld, M., Tomkinson, AE., Izumi, T., Prasad R., Wilson, SH., Mitra S., Hazra TK. AP Endonuclease-independent DNA base excision repair in human cells. Mol Cell, 15:209-220, 2004. PMID: 15260972
  4. Banerjee D, Mandal SM, Das A, Hegde ML, Das S, Bhakat KK, Boldogh I, Sarkar PS, Mitra S, Hazra TK. Preferential repair of oxidized base damage in the transcribed genes of mammalian cells. J Biol Chem. 2011 286: 6006-16 PMID: 21169365 PMCID:PMC3057786
  5. Mandal SM, Hegde ML, Chatterjee A, Hegde PM, Szczesny B, Banerjee D, Boldogh I, Gao R, Falkenberg M, Gustafsson M, Sarkar PS, Hazra TK. 2012. The role of human DNA glycosylase NEIL2 and the single-strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of the mitochondrial genome. J Biol Chem. 287:2819-29. PMID: 22130663 PMCID: PMC3268439
Education
Degree/Training CompletedYearName & Location
B.Sc Chemistry1982Calcutta University, India
M.Sc Biochemistry1985Calcutta University, India
Ph.D Biochemistry1992Jadavpur University, India