Geriatrics & Palliative Medicine

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ResearchGeriatrics


Clinical Trials are research studies performed in human volunteers to answer specific health questions. Clinical trials are an important step in bringing new treatments to the public and improving health. Our investigators and research teams are dedicated to their research and the safety of their subjects.

Click here for more information on Clinical Trials.

If you are interested in volunteering for a clinical trial, please click here to be redirected to our Volunteer Registry with the Claude Pepper

Current investigations are underway on Selenium and Vitamin E in prevention of Prostate Cancer in older men, as well as Vitamin E and Selenium in the prevention of Alzheimer's Disease under the expertise and supervision of Dr. Mukaila Raji. This research project is in its 6th year with a remaining 6 years to go and funded by the Southwest Oncology Group. Subjects involved in the trial will continue to be evaluated for the rest of their lives.    

ACE Research

The   Acute Care for Elders (ACE) Unit at UTMB was the first hospital unit in Texas Designed exclusively to care for the acutely ill older adults and uses an interdisciplinary team model to help prevent the physical decline and weakness that can occur with hospitalization.

In 2003 and 2004 the ACE unit was ranked #1 nationwide in patient satisfaction among 900 geriatric hospital units surveyed by Press Ganey Associates.

In 2005, the ACE unit was expanded to 52 beds to better serve our growing older population and to focus on clinical research. The ACE unit is now the largest in the country with a patient service and clinical research mission.

Why Study hospitalized patients?

  • To provide outstanding patient care and service
  • To enhance patient quality of life
  • To plan programs of excellence that focus on the whole patient - mind and body.

What happens if I volunteer?

Trained professionals perform simple tests and ask you questions about your current health and well-being. For example, if you are well enough, you may be asked to walk a short distance down the hall, to see how long it takes. All research is carefully screened for safety and you are never personally identified. You are always told what will happen. You may refuse at any time.

Better understanding factors leading to disability may:

  • help delay the onset of functional impairment
  • help maintain independence
  • help reduce length of hospitalization
  • help reduce institutionalization
  • help improve psychological health and quality of life
  • provide social, health and economic benefits to patients and their families

For more information, please contact:

ACE Unit Research
UTMB Jennie Sealy Hospital
301 University Blvd.
Galveston, TX 77555

409.772.1955
800.298.7015

ACE Unit Research: Growing older smarter

The Impact of Substance Use Disorder on COVID-19 Outcomes.
Baillargeon J, Polychronopoulou E, Kuo YF, Raji MA. The Impact of Substance Use Disorder on COVID-19 Outcomes. Psychiatr Serv. 2020 Nov 3:appips202000534. doi: 10.1176/appi.ps.202000534. Epub ahead of print. PMID: 33138712.

Addressing Palliative Care Needs of COVID-19 Patients in New Orleans, LA: A Team-Based Reflective Analysis.
Burke RV, Rome R, Constanza K, Amedee M, Santos C, Leigh A. Addressing Palliative Care Needs of COVID-19 Patients in New Orleans, LA: A Team-Based Reflective Analysis. Palliat Med Rep. 2020 Jul 22;1(1):124-128. doi: 10.1089/pmr.2020.0057. PMID: 32856024; PMCID: PMC7446248.

Predictors of functional dependence after COVID-19: A retrospective examination among veterans.
Leigh AE, McCall J, Burke RV, Rome R, Raines AM. Predictors of functional dependence after COVID-19: A retrospective examination among veterans. Am J Phys Med Rehabil. 2020 Oct 12. doi: 10.1097/PHM.0000000000001614. Epub ahead of print. PMID: 33048890.

Trends in Urine Drug Testing Among Long-term Opiod Users, 2012-2018.
Taha SA, Westra JR, Raji MA, Kuo YF. Trends in Urine Drug Testing Among Long-term Opioid Users, 2012-2018. Am J Prev Med. 2020 Dec 4:S0749-3797(20)30470-0. doi: 10.1016/j.amepre.2020.10.011. Epub ahead of print. PMID: 33288392.

Gender differences in diversion among non-medical users of prescription opioids and sedatives.
Milani SA, Lloyd SL, Serdarevic M, Cottler LB, Striley CW. Gender differences in diversion among non-medical users of prescription opioids and sedatives. Am J Drug Alcohol Abuse. 2020 May 3;46(3):340-347. doi: 10.1080/00952990.2019.1708086. Epub 2020 Jan 14. PMID: 31935131.

Characteristics Associated With Feeding Tube Placement: Retrospective Cohort Study of Texas Nursing Home Residents With Advanced Dementia.
Shepard V, Chou LN, Kuo YF, Raji M. Characteristics Associated With Feeding Tube Placement: Retrospective Cohort Study of Texas Nursing Home Residents With Advanced Dementia. J Am Med Dir Assoc. 2020 Nov 22:S1525-8610(20)30923-3. doi: 10.1016/j.jamda.2020.10.033. Epub ahead of print. PMID: 33238144

Assessing Association Between Team Structure and Health Outcome and Cost by Social Network Analysis.
Kuo YF, Agrawal P, Chou LN, Jupiter D, Raji MA. Assessing Association Between Team Structure and Health Outcome and Cost by Social Network Analysis. J Am Geriatr Soc. 2020 Dec 1. doi: 10.1111/jgs.16962. Epub ahead of print. PMID: 33289067.

Epigenetic variations due to nutritional status in early-life and its later impact on aging and disease.
Gomez-Verjan JC, Barrera-Vázquez OS, García-Velázquez L, Samper-Ternent R, Arroyo P. Epigenetic variations due to nutritional status in early-life and its later impact on aging and disease. Clin Genet. 2020 Oct;98(4):313-321. doi: 10.1111/cge.13748. Epub 2020 Apr 16. PMID: 32246454.

Association of Social Behaviors With Community Discharge in Patients with Total Hip and Knee Replacement.
Pritchard KT, Hong I, Goodwin JS, Westra JR, Kuo YF, Ottenbacher KJ.Pritchard KT, et al. Among authors: goodwin js. J Am Med Dir Assoc. 2020 Oct 8:S1525-8610(20)30712-X. doi: 10.1016/j.jamda.2020.08.021. Online ahead of print.J Am Med Dir Assoc. 2020. PMID: 33041232 Free

Time Trends in Opioid Use by Dementia Severity in Long-Term Care Nursing Home Residents.
Mehta HB, Kuo YF, Raji M, Li S, Westra J, Goodwin JS.Mehta HB, et al. Among authors: goodwin js. J Am Med Dir Assoc. 2020 Jun 27:S1525-8610(20)30359-5. doi: 10.1016/j.jamda.2020.04.029. Online ahead of print.J Am Med Dir Assoc. 2020. PMID: 32605815

A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries.
Bhasin S, Gill TM, Reuben DB, Latham NK, Ganz DA, Greene EJ, Dziura J, Basaria S, Gurwitz JH, Dykes PC, McMahon S, Storer TW, Gazarian P, Miller ME, Travison TG, Esserman D, Carnie MB, Goehring L, Fagan M, Greenspan SL, Alexander N, Wiggins J, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace RB, Casteel C, Resnick NM, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Meng C, Allore H, Brawley BF, Eder R, McGloin JM, Skokos EA, Duncan PW, Baker D, Boult C, Correa-de-Araujo R, Peduzzi P; STRIDE Trial Investigators.Bhasin S, et al. Among authors: volpi e. N Engl J Med. 2020 Jul 9;383(2):129-140. doi: 10.1056/NEJMoa2002183.N Engl J Med. 2020. PMID: 32640131 Clinical Trial.

Sex Hormones and Novel Corona Virus Infectious Disease (COVID-19).
Al-Lami RA, Urban RJ, Volpi E, Algburi AMA, Baillargeon J.Al-Lami RA, et al. Among authors: volpi e. Mayo Clin Proc. 2020 Aug;95(8):1710-1714. doi: 10.1016/j.mayocp.2020.05.013. Epub 2020 May 29.Mayo Clin Proc. 2020. PMID: 32753145 Free PMC article. Review.

 

 

The Sealy Center on Aging was established in 1995 to integrate the resources and activities at the University of Texas Medical Branch devoted to research and education relevant to aging. The Sealy Center on Aging is directed by Elena Volpi, M.D., Ph.D., and is comprised of Senior Fellows and Fellows, graduate students, postdoctoral fellows, and staff who are involved in aging reseaarch and scholarly activities.