William J. Calhoun, MD, FACP, FCCP, FAAAAI, FACAAI
William J. Calhoun, MD, FACP, FCCP, FAAAAI, FACAAI
Vice Chair for Research

Division: Pulmonary Critical Care & Sleep Medicine
Department: Internal Medicine

Research Interests
  • Role of alveolar macrophage in asthma
  • Cytokine regulation of airway inflammation in asthma
  • Functional genomics in asthma
  • Severe asthma
  • Glucocorticoid receptor structure and function in asthma
Clinical Interests
  • Asthma, including severe asthma
  • COPD
  • Immunologic Lung Diseases
  • Interstitial Lung Diseases
  • Occupational Lung Diseases
  • Allergic diseases of respiratory tract, eyes, and skin
Selected Publications
  1. Calhoun, W.J., Lavins, B.J., Minkwitz, M.C., Evans, R., Gleich, G.J., Cohn, J. Effect of Zafirlukast (Accolate) on cellular mediators of inflammation: Bronchoalveolar lavage fluid findings after segmental antigen challenge. Am. J. Respir. Crit. Care Med. 157 5(1):1381-1389, 1998.
  2. Ameredes BT, Calhoun W.J. Modulation of GM-CSF release by enantiomeric beta-agonists in human airway smooth muscle. J Allergy Clin Immunol. 116(1):65-72, 2005.
  3. Ogawa,Y., Calhoun, W.J. The role of leukotrienes in airway inflammation. J Allergy Clin Immunol. 118(4):789-98, 2006.
  4. Brasier, A.R, Victor, S., Boetticher, G.D., Ju, H, Lee, C., Bleecker, E.R., Castro, M., Busse, W.W., Calhoun W.J. Molecular Phenotyping of Severe Asthma Using Pattern Recognition of Bronchoalveolar Lavage-Derived Cytokines. J. Allergy Clin. Immun., 121(1);30-37, 2008.
  5. Kumar, R., Calhoun, WJ, Differential regulation of the transcriptional activity of the glucocorticoid receptor through site-specific phosphorylation. Biologics: Targets &Therapy 0000:0(0) 1-10. Epub 2008 Jul 08.
Degree/Training CompletedYearName & Location
M.D.1979Pennsylvania State University, Hershey, PA
Residency1982Pennsylvania State University, Hershey, PA
Fellowship1985University of Vermont, Burlington, VT
Fellowship1992University of Wisconsin, Madison, WI
2005 Certificate in Medical and Health Care Management2005Rice University, Houston, TX