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Welcome to the Department of Internal Medicine

IM Fast Facts

Hayek, Salim, MDA Message from the Chair
Department of Internal Medicine

Salim Hayek, MD, FAHA, FACC

 

 

Welcome to the University of Texas Medical Branch Department of Internal Medicine! We are proud to offer advanced medical care, research, and training in the region’s only academic health science center south of Houston.

Our work is shaped by the unique places we practice and the patients for whom we care. Based on Galveston Island and with hospital and clinic locations throughout our mainland communities, our medical practice is diverse in every way – the patients we have the privilege to serve, the illnesses we treat, and the places where we work.

Our vision combines top-notch clinical care with education and research, transforming how we care for patients, teach our students, and expand our knowledge. At UTMB, supported by the Galveston National Laboratory and the nation’s #1 Microbiology department for NIH funding, we create an environment where research and patient care go hand in hand. Through UTMB’s Clinical Translational Sciences Award, we operate a state-of-the-art Clinical Research Center to conduct clinical trials, PI-initiated studies, and industry-sponsored studies that will help shape the future of medicine. Our commitment to innovation drives new solutions, like AI tools that help clinicians practice more efficiently and improve patient care.

UTMB has formed important partnerships that push the boundaries of traditional medicine, making us stronger and more adaptable. We provide essential telehealth care to passengers at sea through our innovative cruise ship medicine program. Our Aerospace Medicine program prepares doctors to deliver care in extreme environments. Our expertise reaches the most remote locations through UTMB’s medical contract with the National Science Foundation in Antarctica. We train and practice in the secure UTMB – Texas Department of Criminal Justice Hospital, the only hospital for care of the incarcerated on a major academic medical center campus.

In a region that has endured many storms, UTMB is an indisputably resilient institution. From our beginnings as a safety-net hospital to our growth into a comprehensive health care system, we have always supported our community through natural disasters, explosions, a pandemic, and more. For prospective faculty, UTMB offers an environment where you can build a fulfilling career and live up to the mission of providing exceptional care to all. Our promise to our patients is this: no matter who you are or what your circumstances, we are dedicated to providing you with the best possible care.

 

Salim Hayek, MD, FAHA, FACC
Edward Randall and Edward Randall Jr. Distinguished Chair in Internal Medicine
Professor and Chair, Department of Internal Medicine

 Special Announcements

Publication of the Week - 07/01/2025

Title

Analysis of Proteins and Piwi-Interacting RNA Cargo of Extracellular Vesicles (EVs) Isolated from Human Nose Organoids and Nasopharyngeal Secretions of Children with RSV Infections

Authors

Tiziana Corsello, Nicholas Dillman, Yingxin Zhao, Teodora Ivanciuc, Tianshuang Liu, Antonella Casola, and Roberto P. Garofalo

Journal

Viruses

Background

Respiratory syncytial virus (RSV) is the leading cause of respiratory infections in children. Extracellular vesicles (EVs), released by airway epithelial cells, contain proteins and different families of non-coding RNAs (EV cargo) that can modulate the responses of target cells to viral infection. Nasal mucosa is a primary site of viral entry and the source of EVs present in the upper airway secretions. In this study we characterized proteins, including inflammatory mediators and cytokines, and the piwi- interacting RNA (piNAs) cargo of EVs isolated from pediatric human nose organoids (HNO) and nasopharyngeal secretions (NPS) positive for RSV. Using Proximity Extension Assay (PEA) and Luminex multi-target arrays, we found significant enrichment in several chemokines and other mediators/biomarkers, including CCL2, CCL20, CXCL5, CX3CL1, CXCL6, MMP-1, MMP10, uPA, FitL, ARNT and CD40 in EVs secreted by RSV-infected HNO compared to control mock HNO. Analysis of NPS samples from RSV infected children revealed that CCL3, CCL20, CXCL8, uPA, VEGFA, were concentrated in the NPS-EV fraction. LC-MS/MS and Gene Ontology indicated that RSV positive NPS-EVs originate from different cellular sources, with the most abundant proteins from neutrophils and epithelial cells. A total of 490 piRNAs were detected by NGS sequencing of small RNA libraries obtained from NPS-EVs, which has not been reported prior to this study. Identification of inflammatory mediators and small non-coding RNAs which are compartmentalized in EVs contributes to understanding mechanisms of virus-mediated pathogenesis in RSV infections.

 Internal Medicine News

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 Events

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Grand Rounds will resume
January 11, 2024.