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Publications

  1. Tang TZ, Zhao Y, Agarwal D, Tharzeen A, Patrikeev I, Zhang Y, DeJesus J, Bossmann SH, Natarajan B, Motamedi M, Szczesny B. (2024) Serum Amyloid A and Mitochondrial DNA in Extracellular Vesicles are Novel Markers for Detecting Traumatic Brain Injury in a Mouse Model. iScience 27(2): 108932. PMID: 38323004
  2. Labastida, JA, Motamedi M, Wu P, Szczesny B. (2024) Protocol for inducing varying TBI severity in a mouse model using a closed-head, weight-drop, impact-induced acceleration mechanism. STAR Protocol 5(4): 103370 PMID: 39392749
  3. Buscho SE, Xia F, Shi S, Lin JL, Szczesny B, Zhang W, Motamedi M, Liu H. (2023) Non-Invasive Evaluation of Retinal Vascular Alterations in a Mouse Model of Optic Neuritis by Laser Speckle Flowgraphy and Optical Coherence Tomography Angiography. Cells 12(23): 2685. PMID: 38067113
  4. Karlowicz A, Dubiel AB, Czerwinska J, Bledea A, Purzycki P, Grzelewska M, McAuley RJ, Szczesny RJ, Brzuska G, Krol E, Szczesny B, Szymanski MR. (2022) In vitro reconstitution reveals a key role of human mitochondrial EXOG in RNA primer processing. Nucleic Acids Res. 50(14): 7991-8007. PMID: 35819194
  5. Saada J, McAuley RJ, Marcatti M, Tang TZ, Motamedi M, Szczesny B. (2022) Oxidative stress induces Z-DNA-binding protein 1-dependent activation of microglia via mtDNA released from retinal pigment epithelial cells. J Biol Chem. 298(1): 101523. PMID: 34953858
  6. Marcatti M, Saada J, Okereke I, Wade CE, Bossmann SH, Motamedi M, Szczesny B. (2021) Quantification of Circulating Cell Free Mitochondrial DNA in Extracellular Vesicles with PicoGreen™ in Liquid Biopsies: Fast Assessment of Disease/Trauma Severity. Cells 10(4): 819. PMID: 33917426
  7. Sengupta S, Wang H, Yang C, Szczesny B, Hegde ML, Mitra S. (2020) Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription. Proc Natl Acad Sci U S A. 117 (36): 22183-22192. PMID: 32826329
  8. Wen JJ, Cummins CB, Szczesny B, Radhakrishnan RS. (2020) Cardiac Dysfunction after Burn Injury: Role of the AMPK-SIRT1-PGC1α-NFE2L2-ARE Pathway. J Am Coll Surg. 230(4): 562-571. PMID: 32032722
  9. Ahmad A, Haas De Mello A, Szczesny B, Törö G, Marcatti M, Druzhyna N, Liaudet L, Tarantini S, Salomao R, Garcia Soriano F, Szabo C. (2020) Effects of The Poly(ADP-ribose) Polymerase Inhibitor Olaparib in Cerulein-Induced Pancreatitis. Shock. 53(5): 653-665. PMID: 31274831
  10. Ahmad A, Vieira JC, de Mello AH, de Lima TM, Ariga SK, Barbeiro DF, Barbeiro HV, Szczesny B, Törö G, Druzhyna N, Randi EB, Marcatti M, Toliver-Kinsky T, Kiss A, Liaudet L, Salomao R, Soriano FG, Szabo C. (2019) The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological drug for the experimental therapy of sepsis. Pharmacol Res.145: 104263. PMID: 31071432
  11. Koo SJ, Szczesny B, Wan X, Putluri N, Garg NJ. (2018) Pentose Phosphate Shunt Modulates Reactive Oxygen Species and Nitric Oxide Production Controlling Trypanosoma cruzi in Macrophages. Front Immunol. 9: 202. PMID: 29503646
  12. Szczesny B, Marcatti M, Ahmad A, Montalbano M, Brunyánszki A, Bibli SI, Papapetropoulos A, Szabo C. (2018) Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells. Sci Rep. 8(1):914. PMID: 29343810
  13. Ibitokou SA, Dillon BE, Sinha M, Szczesny B, Delgadillo A, Reda Abdelrahman D, Szabo C, AbuElheiga L, Porter C, Tuvdendorj D, Stephens R. (2018) Early Inhibition of Fatty Acid Synthesis Reduces Generation of Memory Precursor Effector T Cells in Chronic Infection. J Immunol. 200(2): 643-656. PMID: 29237780
  14. López-García I, Gerő D, Szczesny B, Szoleczky P, Olah G, Módis K, Zhang K, Gao J, Wu P, Sowers LC, DeWitt D, Prough DS, Szabo C. (2018) Development of a stretch-induced neurotrauma model for medium-throughput screening in vitro: identification of rifampicin as a neuroprotectant. Br J Pharmacol. 175(2): 284-300. PMID: 27723079
  15. López-García I, Gerő D, Szczesny B, Szoleczky P, Olah G, Módis K, Zhang K, Gao J, Wu P, Sowers LC, DeWitt D, Prough DS, Szabo C. (2018) Development of a stretch-induced neurotrauma model for medium-throughput screening in vitro: identification of rifampicin as a neuroprotectant. Br J Pharmacol. 175(2): 284-300. PMID: 27723079
  16. Oláh G, Módis K, Törö G, Hellmich MR, Szczesny B, Szabo C. (2017) Role of endogenous and exogenous nitric oxide, carbon monoxide and hydrogen sulfide in HCT116 colon cancer cell proliferation. Biochem Pharmacol. 149: 186-204. PMID: 29074106
  17. Phillips CM, Zatarain JR, Nicholls ME, Porter C, Widen SG, Thanki K, Johnson P, Jawad MU, Moyer MP, Randall JW, Hellmich JL, Maskey M, Qiu S, Wood TG, Druzhyna N, Szczesny B, Módis K, Szabo C, Chao C, Hellmich MR. (2017) Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis. Cancer Res. 77(21): 5741-5754. PMID: 28923859
  18. Korkmaz-Icöz S*, Szczesny B*, Marcatti M, Li S, Ruppert M, Lasitschka F, Loganathan S, Szabó C, Szabó G. (2017) Olaparib protects cardiomyocytes against oxidative stress and improves graft contractility during the early phase after heart transplantation in rats. Br J Pharmacol 175(2): 246-261 PMID: 28806493  *Both authors contributed equally to the publication
  19. Steiger AK, Marcatti M, Szabo C, Szczesny B, Pluth MD. (2017) Inhibition of Mitochondrial Bioenergetics by Esterase-Triggered COS/H2S Donors. ACS Chem Biol. 12(8): 2117-2123. PMID: 28613823
  20. Szczesny B, Marcatti M, Zatarain JR, Druzhyna N, Wiktorowicz JE, Nagy P, Hellmich MR, Szabo C. (2016) Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics. Sci Rep. 6: 36125. PMID: 27808278
  21. Szczesny B, Marcatti M, Zatarain JR, Druzhyna N, Wiktorowicz JE, Nagy P, Hellmich MR, Szabo C. (2016) Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics. Sci Rep. 6: 36125. PMID: 27808278
  22. Szczesny B, Marcatti M, Zatarain JR, Druzhyna N, Wiktorowicz JE, Nagy P, Hellmich MR, Szabo C. (2016) Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics. Sci Rep. 6: 36125. PMID: 27808278
  23. Koo SJ, Chowdhury IH, Szczesny B, Wan X, Garg NJ. (2016) Macrophages Promote Oxidative Metabolism To Drive Nitric Oxide Generation in Response to Trypanosoma cruzi. Infect Immun. 84(12): 3527-3541. PMID: 27698021
  24. Druzhyna N, Szczesny B, Olah G, Módis K, Asimakopoulou A, Pavlidou A, Szoleczky P, Gerö D, Yanagi K, Törö G, López-García I, Myrianthopoulos V, Mikros E, Zatarain JR, Chao C, Papapetropoulos A, Hellmich MR, Szabo C. (2016) Screening of a composite library of clinically used drugs and well characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer. Pharmacol Res. 113(Pt A): 18-37. PMID: 27521834
  25. Chao C, Zatarain JR, Ding Y, Coletta C, Mrazek AA, Druzhyna N, Johnson P, Chen H, Hellmich JL, Asimakopoulou A, Yanagi K, Olah G, Szoleczky P, Törö G, Bohanon FJ, Cheema M, Lewis R, Eckelbarger D, Ahmad A, Módis K, Untereiner A, Szczesny B, Papapetropoulos A, Zhou J, Hellmich MR, Szabo C. (2016) Cystathionine-beta-synthase inhibition for colon cancer: Enhancement of the efficacy of aminooxyacetic acid via the prodrug approach. Mol Med. 22: 361-379. PMID: 27257787
  26. Brunyanszki A, Szczesny B, Virág L and Szabo C. (2016) Mitochondrial Poly (ADP-ribose) Polymerase: The Wizard of Oz at Work. Free Radic Biol Med, 100: 257-270. PMID: 26964508
  27. Brunyanszki A, Szczesny B, Virág L and Szabo C. (2016) Mitochondrial Poly (ADP-ribose) Polymerase: The Wizard of Oz at Work. Free Radic Biol Med, 100: 257-270. PMID: 26964508
  28. Porter C, Herndon DN, Bhattarai N, Ogunbileje JO, Szczesny B, Szabo C, Toliver-Kinsky T and Sidossis LS. (2016) Differential acute and chronic effects of burn trauma on murine skeletal muscle bioenergetics. Burns. 42: 112-122. PMID: 26615714
  29. Rios EC, Soriano FG, Olah G, Gerö D, Szczesny B, Szabo C. (2016) Hydrogen sulfide modulates chromatin remodeling and inflammatory mediator production in response to endotoxin, but does not play a role in the development of endotoxin tolerance. J Inflamm (Lond) 13: 10. PMID: 27042162
  30. Ahmad A, Olah G, Szczesny B, Wood ME, Whiteman M, Szabo C. (2016) AP39, A Mitochondrially- Targeted Hydrogen Sulfide Donor, Exerts Protective Effects in Renal Epithelial Cells Subjected to Oxidative Stress in Vitro and in Acute Renal Injury in Vivo. Shock. 45(1): 88-97. PMID: 26513708
  31. Szczesny B, Brunyánszki A, Ahmad A, Oláh G, Porter C, Toliver-Kinsky T, Sidossis L, Herndon DN and Szabo C. (2015) Time-dependent and organ-specific changes in mitochondrial function, mitochondrial DNA integrity, oxidative stress and mononuclear cell infiltration in a mouse model of burn injury. PLoS One. 10(12): e0143730. PMID: 26630679
  32. Brunyanszki A, Erdelyi K, Szczesny B, Olah G, Salomao R, Herndon DN, Szabo C. (2015) Upregulation and mitochondrial sequestration of hemoglobins occurs in circulating leukocytes during critical illness, conferring a cytoprotective phenotype. Mol Med. 21(1): 666-97. PMID: 26322851
  33. Olah G, Szczesny B, Brunyanszki A, Lopez-Garcia I, Gero D, Radak Z and Szabo C. (2015) Differentiation-associated downregulation of poly(ADP-ribose) polymerase-1 expression in myoblasts serves to increase their oxidative stress resistance. PLoS One. 10(7): e0134227. PMID: 26218895
  34. Budworth H, Harris FR, Williams P, Lee DY, Holt A, Pahnke J, Szczesny B, Acevedo-Torres K, Ayala-Peña S, McMurray CT (2015) Suppression of somatic expansion delays the onset of pathophysiology in a mouse model of Huntington’s disease. PLoS Genetics. 11(8): e1005267. PMID: 26247199
  35. Porter C, Herndon DN, Bhattarai N, Ogunbileje JO, Szczesny B, Szabo C, Toliver-Kinsky T, Sidossis LS. (2015) Severe Burn Injury Induces Thermogenically Functional Mitochondria in Murine White Adipose Tissue. Shock. 44(3): 258-64. PMID: 26009824
  36. Rios EC, Szczesny B, Soriano FG, Olah G, Szabo C. (2015) Hydrogen sulfide attenuates cytokine production through the modulation of chromatin remodeling. Int J Mol Med. 35(6): 1741-6. PMID: 25873160
  37. Coletta C, Módis K, Szczesny B, Brunyánszki A, Oláh G, Rios EC, Yanagi K, Ahmad A, Papapetropoulos A, Szabo C (2015) Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by -α-Lipoic Acid. Mol Med. 21(1): 1-14. PMID: 25715337
  38. Szczesny B, Brunyanszki A, Olah G, Mitra S, Szabo C. (2014) Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function. Nucleic Acids Res. 42: 13161-73. PMID: 25378300
  39. Brunyanszki A, Olah G, Coletta C, Szczesny B, Szabo C. (2014) Regulation of mitochondrial poly(ADP-ribose) polymerase activation by the b-adrenoceptor/cAMP/proteinase kinase A axis during oxidative stress. Mol Pharmacol, 86: 450-62. PMID: 25069723
  40. Szczesny B, Módis K, Yanagi K, Coletta C, Le Trionnaire S, Wood ME, Whiteman M, Szabo C. (2014) AP39, a hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro. Nitric Oxide. 41: 120-30. PMID: 24755204
  41. Módis K, Coletta C, Asimakopoulou A, Szczesny B, Chao C, Papapetropoulos A, Hellmich MR3, Szabo C (2014) Effect of S-adenosyl-l-methionine (SAM), an allosteric activator of cystathionine-βsynthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro. Nitric Oxide. 41: 146-56. PMID: 24667534
  42. Trionnaire SL, Perry A, Szczesny B, Szabo C, Winyard PG, Whatmore JL, Wood ME and Whiteman M. (2014) The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy) decyl) triphenylphosphonium bromide (AP39) Med. Chem. Commun., 5: 728-736. c3md00323j
  43. Szczesny B, Olah G, Walker DK, Volpi E, Rasmussen BB, Szabo C and Mitra S. (2013) Deficiency in Repair of the Mitochondrial Genome Sensitizes Proliferating C2C12 Myoblasts to Oxidative Damage. PLoS One 8(9):e75201. PMID: 24066171
  44. Szabo C, Coletta C, Chao C, Modis K, Szczesny B, Papapetropoulus A and Hellmich MR (2013) Tumor-derived H2S, produced by cystathionine-b-synthase, stimulates bioenergetics, cell proliferation and angiogenesis in colon cancer. Proc Natl Acad Sci USA, 110(30): 12474-9. PMID: 23836652
  45. Tsutakawa SE, Shin DS, Mol CD, Izumi T, Arvai AS, Mantha AK, Szczesny B, Ivanov IN, Hosfield DJ, Pique ME, Frankel KA, Hitomi K, Cunningham RP, Mitra S, Tainer JA. (2013) Conserved structural chemistry for incision activity in structurally non-homologous APE1 and Endonuclease IV DNA repair enzymes. J. Biol. Chem. 288(12): 8445-55. PMID: 23355472
  46. Bacsi A, Aguilera-Aguirre L, Szczesny B, Radak Z, Hazra TK, Sur S, Ba X and Boldogh I. (2013) Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation. DNA Repair 12(1): 18-26. PMID: 23127499
  47. Hegde ML, Mantha AK, Bhakat, KK, Hazra TK, Mitra S and Szczesny B. (2012) Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases. Mech Ageing Dev. 133(4): 157-68. PMID: 22313689
  48. Mandal SM, Hegde ML, Hegde PM, Banerjee D, Szczesny B, Boldogh I, Falkenberg M, Gustafsson CM, Sarkar PS, and Hazra TK. (2012) Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome. J. Biol. Chem 287 (4): 2819-29. PMID: 22130663
  49. Tann AW, Boldogh I, Meiss G, Qian W, van Houten B, Mitra S and Szczesny B. (2011) Apoptosis induced by single-strand breaks in the mitochondrial genome: critical role of mitochondrial 5’ exo/endonuclease, EXOG. J. Biol. Chem. 286 (3): 1975-83. PMID: 21768646
  50. Zhang H, Xie C, Spencer HJ, Zuo C, Higuchi M, Ranganathan G, Kern PA, Chou MW, Huang Q, Szczesny B, Mitra S, Watson AJ, Margison GP and Fan CY. (2011) Obesity and hepatosteatosis in mice with enhanced oxidative DNA damage processing in mitochondria. Am J Pathol. 178: 1715-27. PMID: 21435453
  51. Kieper J, Lauber C, Gimadutdinow O, Urbańska A, Cymerman I, Ghosh M, Szczesny B and Meiss G. (2010) Production and characterization of recombinant protein preparations of Endonuclease Ghomologs from yeast, C. elegans and humans. Protein Expression and Purification. 73: 99-106. PMID: 20382228
  52. Szczesny B, Tann AW and Mitra S. (2010) Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury. Mech Ageing Dev. 131 (5): 330-337. PMID: 20363243
  53. Szczesny B, Tann AW, Longley MJ, Copeland WC and Mitra, S. (2008) Long patch base excision repair in mammalian mitochondrial genomes. J. Biol. Chem. 283 (39): 26349-56. PMID: 18635552
  54. Mitra S, Izumi T, Boldogh I, Bhakat KK, Chattopadhyay R and Szczesny B. (2007) Intracellular trafficking and regulation of mammalian AP-endonuclease I (APE1), an essential DNA repair protein. DNA Repair 6 (4): 461-469. PMID: 17166779
  55. Chattopadhyay R, Widerhold L, Szczesny B, Izumi T, Hazra TK and Mitra, S. (2006) Identification and characterization of mitochondrial AP-endonuclease in mammalian cells. Nucleic Acids Res. 34 (7): 2067-2076. PMID: 16617147
  56. Szczesny B and Mitra S. (2005) Effect of aging on intracellular distribution of abasic (AP) endonuclease 1 in the mouse liver. Mech Ageing Dev. 126 (10): 1071-1078. PMID: 15951004
  57. Szczesny B, Bhakat KK, Mitra S and Boldogh I. (2004) Age-dependent modulation of DNA repair enzymes by covalent modification and subcellular distribution. Mech Ageing Dev. 125 (10-11): 755-765. PMID: 15541770
  58. Gibala M*, Szczesny B*, Kieleczawa J and Janska H. (2004) The pea mitochondrial atp6: RNA editing and similarity of presequences in the Vicieae tribe. Curr Genet. 46 (4): 235-239. PMID: 15322816  *Both authors contributed equally to the publication.
  59. Szczesny B, Hazra TK, Papaconstantinou J, Mitra S, Boldogh I. (2003) Age-dependent deficiency in import of mitochondrial DNA glycosylase required for repair of oxidatively damage bases. Proc Natl Acad Sci USA, 100 (19): 10670-10675. PMID: 12960370
  60. Kolodziejczak M, Kolaczkowska A, Szczesny B, Urantowka A, Knorpp C, Kieleczawa J, Janska H. (2002) A higher plant mitochondrial homologue of the yeast m-AAA protease. Molecular cloning, localization, and putative function. J. Biol. Chem. 277 (46): 43792-437928.PMID: 12228240