Lawrence C. Sowers, PhD
Professor and Chair, Department of Pharmacology & Toxicology
Tel: (409) 772-9678
Fax: (409) 772-9648
E-mail: lasowers@utmb.edu
Campus Location:3.336 Basic Science Bldg
Mail Route: 0617
Research
His work has involved the chemistry and biology of DNA damage resulting
from both carcinogens and cancer chemotherapy agents. More recently, he
has focused upon damage to DNA resulting from reactive molecules
generated by activated inflammatory cells including eosinophils and
neutrophils. He has recently demonstrated how certain
inflammation-mediated DNA damage products could mimic epigenetic
signals, perhaps explaining how inflammation could result in heritable
changes in genes expression important for the silencing of tumor
suppressor genes in the development of cancer, and how early exposure to
agents that trigger inflammation could influence disease susceptibility
later in life. His laboratory has trained numerous PhD, MD and
MD/PhD students over the years and he looks forward to training
further students within the context of this translational and
interdisciplinary program in Galveston.