What are the hepatitis B vaccines licensed for use in the United States?
Three single-antigen vaccines, one three-antigen vaccine, and three combination vaccines are currently licensed in the United States. Single-antigen hepatitis B vaccines, Engerix-B, Recombivax HB, Heplisav-B. (CDC)
What are the recommended schedules for hepatitis B vaccination?
The vaccination schedule most often used for adults is three intramuscular injections, the second and third doses administered at 1 and as early as 4 months, or at 6 months, respectively, after the first dose. Alternate schedules have been approved for certain vaccines and/or populations.
A new formulation, Heplisav-B (HepB-CpG), is approved for two doses, 1 month apart. (CDC)
Can a patient receive the first dose of hepatitis B vaccine from one manufacturer and subsequent doses from another manufacturer?
Yes. When feasible, vaccines from the same manufacturer should be used to complete the series, but vaccination should not be deferred when the manufacturer of the previously administered vaccine is unknown or when the vaccine from the same manufacturer
is unavailable. Different vaccination schedules apply for patients receiving vaccines from different manufacturers; details regarding how to complete the vaccination series using vaccine from a different manufacturer are available. (CDC)
If there is an interruption between doses of hepatitis B vaccine, does the vaccine series need to be restarted?
No. The series does not need to be restarted, but the following should be considered.
- If the vaccine series was interrupted after the first dose, the second dose should be administered as soon as possible.
- The second and third doses should be separated by an interval of at least 8 weeks.
- If only the third dose is delayed, it should be administered as soon as possible.
Is it harmful to administer an extra dose(s) of hepatitis B vaccine or repeat the entire vaccine series if documentation of vaccination history is unavailable?
No. If necessary, administering extra doses of single-antigen hepatitis B vaccine is not harmful. (CDC)
Can hepatitis B vaccine be administered concurrently with other vaccines?
Yes. Administering hepatitis B vaccine at the same time as other vaccines has not been shown to interfere with antibody response. Separate body sites and syringes should be used for simultaneous administration of injectable vaccines. (CDC)
Can anti-HBs levels following vaccination decline over time?
Yes. Following vaccination, anti-HBs levels decline over time. Anti-HBs ≥10 mIU/mL is considered a correlate of vaccine-induced protection for people who have completed an approved vaccination series. (CDC)
How soon can I start the Hep B series?
Once you receive the result on your Hep B titer and if negative, you may start the new Hep B series.
Do I need a titer after my new Hep B series?
Yes, a titer is required to show hepatitis B immunity.