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AgenorLimon

Curriculum Vitae

 

Limon, Agenor, MSc, PhD
Assistant Professor
Mitchell Center for Neurodegenerative Disorders
Department: Neurology

Mailing Address:
301 University Blvd, Route 1045
Galveston, TX 77555-1045

Office: 10.138B Medical Research Building
Phone: 409.772.0077
Lab: 409.772.0064
Fax: 409.747.0015

Education and Post Graduate Training
  • Q.F.B. Chemistry and Pharmacobiology, Faculty of Chemical Sciences. Benemérita Universidad Autónoma de Puebla (BUAP), Puebla, Mexico
  • M.S. Physiological Sciences,  Institute of Physiology. BUAP, Puebla, Mexico. Ad honorem.
  • Ph.D. Physiological Sciences, Institute of Physiology. BUAP, Puebla, Mexico. Cum Laude.
  • Postdoctoral Scholar. Dept. Neurobiology and Behavior, University of California Irvine (UCI), USA.
Research Interest
  • Molecular mechanisms of Excitation-Inhibition imbalance in neurodegenerative diseases (Alzheimer’s disease, cognitive impairment) and mental disorders (schizophrenia, major disorder and autism).
  • Microtransplantation of Synaptic Membranes (MSM) to direct analysis of pharmacological and biophysical remodeling of human native receptors in disease.
  • Identification and validation of therapeutic targets identified by multidimensional analysis of molecular physiology data.
Selected Publications
  • (From 23 peer-reviewed publications) Limon A, Perez C, Soto E, Vega R.  (2005) Ca2+-activated K+ current density is correlated with soma size in rat vestibular afferent neurons in culture. J Neurophysiol; 94: 3751-3761.
  • Cohen JL, Limon A, Miledi R, Chamberlin AR. (2006) Design, Synthesis, and Biological Evaluation of a Scaffold for iGluR Ligands Based on the structure of (-)-Dysiherbaine. Bioorganic and Medicinal Chemistry Letters; 16: 2189-2194.
  • Limon A, Reyes-Ruiz JM, Eusebi F, Miledi R. (2007) Properties of GluR3 receptors tagged with GFP at the amino or carboxyl terminus. Proc Natl Acad Sci USA; 104:15526-15530.
  • Limon A, Reyes-Ruiz JM, Miledi R. (2008) Microtransplantation of neurotransmitter receptors from postmortem autistic brains to Xenopus oocytes. Proc Natl Acad Sci USA; 105: 10973-10977.
  • Perez C, Limon A, Vega R, Soto E. (2009) The muscarinic inhibition of the potassium M-current modulates the action-potential discharge in the vestibular primary-afferent neurons of the rat. Neuroscience; 158:1662-1674.
  • Limon A, Reyes-Ruiz JM, Vaswani R, AR Chamberlin, Miledi R. (2010) Kaitocephalin antagonism of glutamate receptors expressed in Xenopus oocytes. ACS Chem Neurosci; 1: 175-181.
  • Limon A, Reyes-Ruiz JM, Miledi R.(2011) GABAergic drugs and Alzheimer’s. Future Medicinal Chemistry; 3: 149-153.
  • Limon A, Reyes-Ruiz JM, Miledi R. (2012) Loss of functional human GABA receptors in Alzheimer disease. Proc Natl Acad Sci U S A. 109:10071-10076,
  • Conti L, Limon A, Palma E, Miledi R. (2013) Microtransplantation of cellular membranes from squid stellate ganglion reveals ionotropic GABA receptors. Biol Bull. 224: 47-52,
  • Cervantes B, Vega R, Limón A, Soto E (2013) Identity, expression and functional role of the sodium-activated potassium current in vestibular ganglion afferent neurons. Neuroscience. 240: 163-175.
  • Candelario M, Cuellar E, Reyes-Ruiz JM, Darabedian N, Miledi R, Feimeng Z, Russo-Neustadt A, Limon A (2015). Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAA and GABAr receptors. J Ethnopharmacol. 171:264-272.
  • Limon A, Estrada-Mondragón A, Ruiz JM, Miledi R. (2016) Dipicrylamine Modulates GABAρ1 Receptors through Interactions with Residues in the TM4 and Cys-Loop Domains. Mol Pharmacol. 89:446-56.
  • Limon A, Mandamni F, Hjelm B, Vawter M, Sequeira P. (2016) Targets of polyamine dysregulation in major depression and suicide: activity-dependent feedback, excitability and neurotransmission. Neuroscience & Biobehav Rev 60:80-91.

Honors and Awards
  • 2006, Maximiliano Ruiz Castañeda Award for best research in basic sciences. The National Academy of Medicine in Mexico.
  • 2009, Grass Fellowship at the Marine Biological Laboratory in Woods Hole MA, USA, The Grass Foundation.
  • 2009, Member of the Mexican SNI in abroad, Level 1, by the National Council of Science and Technology in Mexico (CONACyT).
  • 2014, Travel Award by the American College of Neuropsychopharmacology, USA.
  • 2016 Member of the Mexican National System of Researchers (SNI) in abroad, Level 2.
Professional Affiliations
  • Member, Society for Neuroscience (SFN)
  • Member, Academy for the Advancement of Science (AAAS)
  • Member, Mexican National System of Researchers in abroad (SNI)
  • Member, International Brain Organization (IBRO)
  • Member, American Society for Pharmacology and Experimental Therapeutics (ASPET)
  • Reviewer, National Council for Science and Technology. Government of Mexico (CONACyT). 2006-
  • Reviewer, National Agency of Evaluation and Prospective for the Government of Spain (ANEP). 2013-.
  • Reviewer, (ColCiencias) Government of Colombia. 2015-
  • Reviewer, Funding of Science and Technology for the Government of Argentina (FONCyT). 2015-