Professors Kayed, Rakez, PhD ProfessorMitchell Center for Neurodegenerative DisordersJohn Sealy Chair for Parkinson's ResearchDepartment: NeurologyBio, Curriculum Vitae Mailing Address: 301 University Blvd, Route 1045 Galveston, TX 77555-1045Office: 10.138C Medical Research Building Phone: 409.772.0138Fax: 409.747.0015 Bio - Kayed, Rakez, PhD Education Research Interest Selected Publications Honors and Awards Professional Affiliations B.S. Chemistry, University of Jordan, Amman, JordanPhD: Organic/Medicinal Chemistry, University of Tübingen, GermanyPost Doctoral: Alzheimer’s and Protein misfolding Diseases, University of California, Irvine, CA Neurodegenerative disease pathology and mechanisms (Alzheimer's (AD), Parkinson's (PD), dementia with Lewy bodies (DLB) and other tauopathies)Mechanisms of protein folding and aggregationMolecular mechanisms behind tau oligomer toxicity, propagation, and role in neurodegenerationImmunotherapeutic approaches targeting amyloid and tau oligomersDiagnostics and biomarkers using CSF and other biological samplesAmyloid oligomers in amyloidosis, cancer, and diabetesTau aggregation in traumatic brain injury (TBI) Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 18; 300(5618):486-9; 2003.Kayed R, Pensalfini A, Margol L, Sokolov Y, Sarsoza F, Head E, Hall J, Glabe C. Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer. J Biol Chem. 13;284(7):4230-7; 2008.Mina EW, Lasagna-Reeves C, Glabe CG, Kayed R. Poloxamer 188 copolymer membrane sealant rescues toxicity of amyloid oligomers in vitro. J Mol Biol. 21;391(3):577-85; 2009.Lasagna-Reeves CA, Castillo-Carranza DL, Guerrero-Muoz MJ, Jackson GR, Kayed R. Preparation and characterization of neurotoxic tau oligomers. Biochemistry. 30;49(47):10039-41;2010.Clos AL., Lasagna-Reeves CA., Castillo-Carranza DL., Sengupta U., Jackson GR., Kelly B., Beachkofsky TM., Kayed R. Formation of immunoglobulin light chain amyloid oligomers in primary cutaneous nodular amyloidosis. British Journal of Dermatology, 165(6):1349-54, 2011.Lasagna-Reeves CA., Castillo-Carranza DL.., Sengupta U., Clos AL., Jackson GR., Kayed R. Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice. Mol Neurodegener. 6;6:39; 2011.Lasagna-Reeves CA., Glabe CG, Kayed R. Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain. J Biol Chem. 286(25):22122-30; 2012.Lasagna-Reeves CA., Castillo-Carranza DL., Sengupta U., Sarmiento J., Troncoso J., Jackson GR., Kayed R. Identification of oligomers at early stages of tau aggregation in Alzheimer's disease. FASEB J. 26(5):1946-59; 2012.Lasagna-Reeves CA., Castillo-Carranza DL., Sengupta U., Guerrero-Munoz MJ., Kiritoshi T., Neugebauer V., Jackson GR., Kayed R. Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau. Sci Rep. 2:700; 2013.Hawkins BE, Krishnamurthy S, Castillo-Carranza DL, Prough DS, Jackson GR, Dewitt DS, Kayed R. Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: Possible link between TBI and sporadic tauopathies. J Biol Chem. 288(23):17042-50; 2013. For a complete list of publications Warmoth Professorship in Neurology, 2012-International Society for Neurochemistry (ISN), 2011Society for Neuroscience Award, 2003DFG Fellow, 1996 Member, Sealy Center for Vaccine Development, 2010Associate Professor, Department of Neuroscience and Cell biology 2012Member, graduate faculty in Neuroscience Graduate Program, UTMB, Galveston, TX, 2008-Member, Graduate faculty in Cell Biology Graduate Program, UTMB, Galveston, TX, 2007-Member, George and Cynthia Mitchell Center for Neurodegenerative Diseases, UTMB, Galveston, TX, 2007-Member, Society for NeuroscienceMember, American Chemical SocietyMember, Biophysical SocietyAssociate Editor: Journal of Alzheimer's Disease (JAD), 2012-Editorial Board Member: Journal of Neurodegenerative Diseases, 2012-.Associate Editor and Editorial Board Member: Frontiers in Dementia, 2010-Session Chair: The Alzheimer's Association International Conference, 2012 and 2013.Invited Guest Editor; International Journal of Alzheimer's Disease (IJAD), special issue: Tau protein: Function and Pathology, 2011Reviewer , Alzheimer Association, USAReviewer, The Technology Foundation STW, HollandReviewer, Michigan Diabetes Research and Training Center (MDRTC)Member, NIH Study section ZRG1 MDCN-C (03) - 2012 and 2013Reviewer, Israeli Ministry of Science and TechnologyReviewer, Alzheimer`s Association, UKReviewer, Medical Research council, UKReviewer, National Science Center, PolandReviewer, German-Israeli foundation for scientific research and development