Associate Professors Krishnan, Balaji, PhD Associate ProfessorDon and Nancy Mafrige Professor in Neurodegenerative ResearchDepartment of NeurologyMitchell Center for Neurodegenerative DiseasesDepartment: NeurologyBio, Curriculum Vitae Mailing Address: 301 University Blvd, Route 1045 Galveston, TX 77555-1045Office: 10.138G Medical Research Building Phone: 409.772.8069Fax: 409.747.0015 Bio - Krishnan, Balaji, PhD Education Research Interest Selected Publications Honors and Awards Professional Affiliations 1992 BSc (Microbiology/Biochemistry),University of Mumbai, INDIA1996 MSc (Molecular Biology/Physics),University of Mumbai, INDIA2003 PhD (Biology),University of Houston, Houston, TX, USA2007 Certificate in Business Administration,University of Houston, Houston, TX, USA2008 Neurobiology,Marine Biological Labs, Woods Hole, MA, USA Synaptic Mechanisms Involved in Long-term Memory Mechanisms Bourne, K.Z., Natarajan, C., Medina Perez C.X., Tumurbaatar, B., Taglialatela, G., and Krishnan, B. (2019). Suppressing aberrant phospholipase D1 signaling in 3xTg Alzheimer’s disease mouse model promotes synaptic resilience. Sci. Rep. doi: 10.1038/1038/s41598-019-54974-6. PMID: In progress; [PMCID: In progress].Krishnan, B., Sallam, H. S., Tumurbataar, B., Saieva, S., Baymon, D., Tuvdendorj, D., Micci, M. A., Abate, N., and Taglialatela, G. (2019). Amelioration of hippocampal dysfunction by adipose tissue-targeted stem cell transplantation in a mouse model of type 2 diabetes. J. Neurochem. doi: 10.1111/jnc.14915. PMID: 31730234; [PMCID: In progress].Micci, M., Krishnan, B., Bishop, E., Zhang, W., Guptarak, J., Grant, A., Zolochevska, O., Tumurbaatar, B., Franklin, W., Marino, C., Widen, S., Luthra, A., Kernie, S., and Taglialatela, G. (2019) Hippocampal stem cells promotes synaptic resistance to the dysfunctional impact of amyloid beta oligomers via secreted exosomes. Mol. Neurodegener., 14(1), 25. PubMed [PMID: 31200742]; PubMed [PMCID: In progress].Franklin, W., Krishnan, B., and Taglialatela, G. (2019). Chronic synaptic insulin resistance after traumatic brain injury abolishes insulin protection from amyloid beta and tau oligomer-induced synaptic dysfunction. Sci. Reports, 9(1): 8228. PubMed [PMID: 31160730]; PubMed [PMCID: In progress].Marino, C., Krishnan, B., Cappello, F., and Taglialatela, G. (2019). Hsp60 protects against Amyloid β oligomer synaptic toxicity via modification of toxic oligomer conformation. ACS Chem. Neurosci., 10.1021/acschemneuro.9b00086. PubMed [PMID: 31091411]; PubMed [PMCID: In progress].Comerota, M., Tumurbaatar, B., Krishnan, B., Kayed, R. and Taglialatela, G. (2019) Near infrared light treatment reduces synaptic levels of toxic tau oligomers in two transgenic mouse models of human tauopathies. Mol. Neurodegener. Aug 17 doi: 10.10007/s12035-018-1248-9; [PMCID: PMC6476871].Krishnan, B., Kayed, R., and Taglialatela, G., (2018) Elevated phospholipase D isoform 1 in Alzheimer's disease patients' hippocampus: Relevance to synaptic dysfunction and memory deficits. Alzheimer’s and Dementia (4): 89-102; PubMed [PMID: 29560412]; PubMed [PMCID: PMC5857521].Comerota, M., Krishnan, B., and Taglialatela, G. (2017) Near infrared light decreases synaptic vulnerability to amyloid beta oligomers. Sci. Reports. 7(1): 1501; PubMed Central [PMID: 29118388]; PubMed Central [PMCID: PMC5678170].Krishnan B. Amygdala-Hippocampal Phospholipase D (PLD) Signaling As Novel Mechanism of Cocaine-Environment Maladaptive Conditioned Responses. Int J Neuropsychopharmacol. 2016 Jan 22. pii: pyv139. doi: 10.1093/ijnp/pyv139. PubMed PMID: 26802567; PubMed Central PMCID: PMC4926798.Krishnan, B., Genzer, K., Pollandt, S., Liu, J., Gallagher, J.P., and P. Shinnick-Gallagher (2011) “Novel D1-like receptor activated long term potentiation (LTP) is apparent during cocaine withdrawal and is linked to phospholipase D (PLD) and metabotropic glutamate receptors (mGluRs).” PLoSONE 6(9): e25639 [PMCID: PMC3181343]Schmidt, K., Krishnan, B., Xia, Y., Sun, A., Orozco-Cabal, L., Pollandt, S., Centeno, M., Genzer, K., Gallagher, J.P., Shinnick-Gallagher, P. and J. Liu (2011) “Cocaine withdrawal reduces group I mGluR-mediated long-term potentiation via decreased GABAergic transmission in the amygdala” EJN 34(2): 177-189 [PMCID: PMC313881223]Krishnan, B., Centeno, M, Pollandt, S., Fu, Y., Liu, J., Gallagher, J.P., and P. Shinnick-Gallagher (2010) “Dopamine receptor mechanisms mediate corticotrophin releasing factor-induced long-term potentiation in the rat amygdala following withdrawal.” EJN 31(6): 1027-1042. [PMCID: PMC3118420]Fu, Y., Pollandt, S., Liu, J., Krishnan, B., Genzer, K., Orozco-Cabal, L., Gallagher, J.P., and P. Shinnick-Gallagher (2007) “Long-term potentiation (LTP) in the central amygdala (CeA) is enhanced after prolonged withdrawal from chronic cocaine and requires CRF1 receptors.” J Neurophysiol (97):937-941.Ge, H., Krishnan, P., Liu, L., Krishnan, B., Davis, R.L., Hardin, P.E., and G. Roman (2006) “A Drosophila non-visual arrestin is required for the maintenance of olfactory sensitivity.” Chem. Senses 31(1):49-62 [PMCID: PMC2180162]Tanouye, S., Krishnan, P., Krishnan, B., Dryer, S.E., and P. E. Hardin (2004) “Circadian clocks in antennal neurons are necessary and sufficient for olfaction rhythms in Drosophila” Curr Biol. 14(8):638-649.Krishnan, B., Levine, J.D., Sisson, K., Dowse, H.B., Funes, P., Hall, J.C., Hardin, P.E., and S. E. Dryer (2001) “A novel role for cryptochrome in a Drosophila circadian oscillator.” Nature (411):313-317.Krishnan, B., Dryer, S.E., and P. E. Hardin (1999) “Circadian rhythms in olfactory responses of Drosophila melanogaster.” Nature (400):375-378. 2012 The Center for Addiction Award for team player activities2011 The Frances Adoue Lynch Addiction Research Fund Award for most promising addiction researcher in the Houston-Galveston area2011 BBC 2011 Travel Award towards travel and oral presentation of research2010 FIRST IV Travel Award towards workshop in teaching for postdoctoral researchers2009 NIDA Travel Award towards the APA 117th Annual Convention, Toronto, Canada2009 USU Travel Award towards the Amygdala Stress and PTSD Conference2009 IRST IV Travel Award towards workshop in teaching for postdoctoral researchers2008 Galveston Travel Award towards attending SFN 20082008 Edwin Grant Conklin Memorial Fund, Horace W. Stunkard Scholarship Fund towardsMarine Biological Labs Neurobiology Course2007 NRSA Ruth L. Kirschstein Postdoctoral Training Research Fellowship (2007-2010)2005 NIH Training Grant towards studying Cocaine Abuse (UTMB Galveston, (2005-2006)2001 Departmental Graduate Achievement Award for outstanding research (Univ. of Houston)2000 NSM Student Challenge Competition (University of Houston)1999 Departmental Travel Award (Biology and Biochemistry, University of Houston)1998 BRAIN Graduate Research Award (University of Houston)1997 Departmental Travel Award (Biology and Biochemistry, University of Houston)1995 ICTP travel award the Antonio Borsellino College on Neurophysics at ICTP, Trieste, Italy Society for Neuroscience