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Faculty Profile

Bio - Sarkar, Partha S., PhD

    • Undergraduate (Honors in Chemistry); Calcutta University, India
    • Master of Science; Indian Institute of Technology, Bombay, India
    • Ph.D.; Molecular Biophysics, Indian Institute of Science, Bangalore, India 
    • Mechanism of degenerative muscle phenotypes in myotonic dystrophy type 1 (DM1)
    • Mechanism of metabolic abnormalities in myotonic dystrophy type 1 (DM1)
    • Huntington disease (HD)
    • Spinocerebellar Ataxia Type 10 (SCA10)
    • Mandal, SM, Hegde ML, Chatterjee A, Hedge PM, Szczesny B, Bannerjee D, Bolgogh I, Gao R, Falkenberg M, Gustafsson CM, Sarkar PS and Hazra T (2012) Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3’-phosphatase in maintenance of mitochondrial genome, J. Biol. Chem., 287, 2819-2829; PMID: 22130663
    • Jones K., Jin B., Polina I., Huichalaf C., Sarkar PS, Schneider-Gold C., Schoser B., Meola G., Shyu A.B., Timchenko N., Timchenko L. (2011): RNA Foci, CUGBP1, and ZNF9 Are the Primary Targets of the Mutant CUG and CCUG Repeats Expanded in Myotonic Dystrophies Type 1 and Type 2., Am J Pathol., PMID: 21889481
    • Zhao Y, Banerjee S, Dey N, Lejeune WS, Sarkar PS, Brobey R, Rosenblatt KP, Tilton RG, Choudhary S. (2011)  Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)-536 Phosphorylation; Diabetes, 60 (7), 1907-1916
    • White MC, Gao R, Xu W, Mandal SM, Lim JG, Hazra TK, Wakamiya M, Edwards SF, Raskin S, Teive HA,  Zoghbi HY, Sarkar PS, Ashizawa T,(2010) Inactivation of hnRNP K by Expanded Intronic AUUCU Repeat Induces Apoptosis via Translocation of PKCδ to Mitochondria in Spinocerebellar Ataxia 10, PLoS Genetics, 6, e1000984; PMID: 20548952
    • Huichalaf C., Sakai K., Jin B., Wang Guo-Li, Schoser B., Schneider-Gold C., Sarkar PS, Olivia M. Pereira-Smith, Timchenko N., and Timchenko LT (2010) Expansion of CUG-RNA repeats causes stress and inhibition of translation in Myotonic Dystrophy, FASEB J., 24, 3706-3719. PMID: 20479119
    • Huichalaf C., Schoser B., Schneider-Gold C., Jin B., Sarkar PS, and Timchenko LT (2009) Reduction of the rate of protein translation in patients with myotonic dystrophy type 2, J. Neuroscience, 29, 9042-9049; PMID: 19605641
    • Salisbury E, Schoser B, Schneider-Gold C, Wang GL, Huichalaf C, Jin B, Sirito M, Sarkar PS, Krahe R, Timchenko NA, Timchenko LT. (2009) Expression of RNA CCUG Repeats Dysregulates Translation and Degradation of Proteins in Myotonic Dystrophy 2 Patients, Am. J. Pathol., 175, 748-762; PMID: 19590039
    • Banerjee D, Mandal SM, Das A, Hegde ML, Das S, Bhakat KK, Nogales E, Boldogh I, Sarkar PS, Mitra S, Hazra TK (2010), NEIL2-Initiated Preferential Repair of Oxidized Base Damage in the Transcribed DNA Strand, J.Biol. Chem, 286, 6086-16: PMID: 21169365
    • Sarkar PS, Paul S., Han J. and Reddy S, (2004) Six5 is required for spermatogenic cell survival and spermiogenesis, Human Molecular Genetics, 13(14), 1421-1431
    • Sarkar PS, Appakutan B, Han J, Ito Y, Ai C, Tsai W, Chai,Y, Stout JT, and Reddy S, (2000) Heterozygous loss of Six5 is sufficient to cause ocular cataract, Nature Genetics, 25, 110
    • Sarkar PS, Chang HC, Boudi FB, and Reddy S, (1998) CTG repeat show bimodal amplification in E.coli. Cell, 95, 531
    • International myotonic dystrophy consortium (IDMC)
    • American Society for Human Genetics (ASHG)
    • International Myotonic Dystrophy Organization (IDMO)