Pappolla, Miguel A., MD, PhD

Mailing Address:
301 University Blvd, Route 0539
Galveston, TX 77555-0539

Office: 2646 S. Loop W. Ste 106
Phone: 713.661.0300 
Fax: 281.822.0480

Education and Post Graduate Training
  • Medical School
    University of Buenos Aires, Argentina (1978)
  • Residency: Anatomic and Pathology
    Northeastern Ohio Universities, July 1980-June 1983
  • Fellowship: Neuropathology
    Case Western Reserve University, July 1983-June 1984
  • Fellowship: Neuropathology
    Cleveland Clinic Foundation, July 1984-June 1985
  • Residency: Neurology
    University of South Alabama, October 1996-September 2000
  • Fellowship: Interventional Pain Management
    (Anesthesia accredited program)
    University of Mississippi, Jackson Mississippi (2005-2006)
  • PhD-Doctorate
    University of Catalunya, Barcelona, Spain (2002)                         
Board Certifications
  • Board Certified and Diplomate in Neurology
  • Board Certified and fellowship trained in Pain Medicine
  • Board Certified in Anatomic and Clinical Pathology
  • Board Certified and fellowship trained in Neuropatholy
  • Neurology and Pain Management
Clinical Interest
  • Neuropathology
  • Interventional Pain Management
Research Interest
  • Alzheimer's Disease
Selected Publications
  • Barnwell E, Padmaraju V, Baranello R, Pacheco-Quinto J, Crosson C, Ablonczy Z, Eckman E, Eckman CB, Ramakrishnan V, Greig NH, Pappolla MA, Sambamurti K. Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein. PLoS One. 2014 Mar 21;9(3):91531.
  • Pinnix I, Ghiso JA, Pappolla MA, Sambamurti K. Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long. Am J Geriatr Psychiatry. 2013 May;21(5):474-83.
  • Sambamurti K, Greig NH, Utsuki T, Barnwell EL, Sharma E, Mazell C, Bhat NR, Kindy MS, Lahiri DK, Pappolla MA. Targets for AD treatment: conflicting messages from γ-secretase inhibitors. J Neurochem. 2011 May;117(3):359-74. 
Honors and Awards
  • Zenith Fellowship Award Alzheimer’s Association
  • James A. Shannon Director’s Award. National Institutes of Health
  • 1990, Commendation Award, for Academic and Clinical Excellence Department of Veterans Affairs, Washington, DC
  • 2000, Weil Award (awarded to the best study in Neuropathology leading to advancements on mechanisms of disease). American Association of Neuropathologists
  • 2001, Teaching Award, Department of Neurology.The University of South Alabama, Given by graduating Neurology residents
  • 2006, Josephine T. Morse Endowed Professorship in NeuropathologyMedical University of South Carolina
  • 2006, Commendation Award for Academic Excellence and LeadershipLSU Health Sciences Center, New Orleans
  • Most Compassionate Doctor Award 2013