Molecular Mechanisms of the Dysregulated Immune Response to Ebola Virus
This NIAID-funded program project at the University of Texas Medical Branch (UTMB) is seeking outstanding investigators to work on the molecular mechanisms of dysregulated immune response to Ebola virus. The collaborative team assembled by this program project is investigating how Ebola virus infection leads to cell-type specific transcriptional, posttranscriptional, and posttranslational alterations that lead to a dysregulated immune response, which paradoxically produces “immune paralysis” and hyperinflammation. The positions will be part of a program that straddles virology, immunology and RNA biology.
The individual projects are described below. The successful candidates are expected to run research projects, write manuscripts, present data at national and international conferences, assist the PI in writing progress reports, grant proposals, protocols for animal experiments, and assist in the supervision of Ph.D. students. Applicants should be highly motivated, able to conduct independent research, and have publications in internationally recognized journals. Excellent communication skills and writing skills are required. Interested candidates should send a cover letter, CV, and contact details for references to the faculty members listed below.
The laboratory of Dr. Alexander Bukreyev, Department of Pathology, is looking for outstanding Research Scientist II and postdoctoral fellows to work on the role of epigenetic and transcriptional mechanisms in the pathogenesis of Ebola virus disease. The work can be extended to additional emerging viruses which require work in biocontainment, including but not limited to Marburg virus, Lassa virus, SARS-CoV-2 and hantaviruses. The work will include experiments in BSL-4 and BSL-2 labs and may be extended to BSL-3 labs. Candidates must have a Ph.D. and should have experience in virology and molecular biology and/or immunology, with preference given to those versed in transcriptional regulation of the immune response and/or epigenetics. A documented experience of work under BSL-4 and/or BSL3 biocontainment is desirable. Interested candidates should contact Dr. Alexander Bukreyev (email@example.com).
The laboratory of Dr. Mariano Garcia-Blanco, Department of Biochemistry and Molecular Biology is looking for outstanding postdoctoral fellows to investigate the posttranscriptional landscape during EBOV infection. This work will synergize with other projects in the laboratory in the interface of RNA biology and immunology. Candidates must have a Ph.D. or equivalent, and should have experience in molecular biology, with preference given to those with experience in RNA biology, genomics and virology. High biocontainment experience is not required for these positions. Interested candidates should contact Dr. Mariano Garcia-Blanco (firstname.lastname@example.org).
The laboratory of Dr. Ricardo Rajsbaum, Department of Microbiology and Immunology, is looking for outstanding postdoctoral fellows to investigate the role of cellular and viral ubiquitination and other post-translational modifications during EBOV infection. The projects are highly collaborative and include work on host-pathogen interactions during infections with other viruses including Influenza, Zika and SARS-CoV-2. Candidates must have a Ph.D. and should have experience in immunology, virology and molecular biology, with preference given to those with experience in ubiquitination and innate immunity. High biocontainment experience is not required but would be a plus. Interested candidates should contact Dr. Ricardo Rajsbaum (email@example.com).
The laboratory of Dr. Andrew Routh (https://www.utmb.edu/routhlab), Department of Biochemistry and Molecular Biology, has immediate openings for research staff scientists.
The positions will support a broad range of activities in the 'Proteogenomics' core of the program project and interface with a multiple investigators on a range of transcriptomic and proteomic projects. Experience with molecular and biochemical techniques, NGS library preparation for approaches including RNAseq, CHIPseq and ATACseq, and downstream computational analyses is essential. Experience using single-cell sequencing using 10X Genomics platforms or long-read nanopore sequencing on Oxford Nanopore Technologies platform is also desirable. A PhD or equivalent industry experience in a field related to biochemistry or molecular biology is required. Interested candidates should contact Dr. Andrew Routh (firstname.lastname@example.org).
The program project team is part of a strong scientific community at UTMB, which includes the Galveston National Laboratory, and the greater Houston area, which includes the Texas Medical Center. Furthermore, the team includes collaborators at the Icahn School of Medicine at Mount Sinai and the Cincinnati Children’s Hospital.
UTMB is situated on Galveston Island that features access to beaches, parks and a Victorian downtown area with nice restaurants and pubs. Galveston is located only 50 miles from the center of Houston, one of the largest and most diverse cities in the United States, and 25 minutes from League City a fast-growing and affordable city that has one of the best school systems in the state.