My primary research focus is hepatic immunology and how dysregulation of the immune response leads to fibrosis development. I am also interested understanding how the phenotype of a person's hepatic macrophages determines downstream immune activation and how they respond to liver injury.
My laboratory is currently working on three main projects:
1. We are currently conducting a clinical study to better understand viral hepatitis C infection by collecting blood samples and liver biopsies in patients before and after treatment with the recently developed IFN-free antivirals. We are using multi-spectral imaging to analyze macrophages, lymphocytes, and liver sinusoidal endothelial cells, before and after treatment, and will use this technology to see how the various cell phenotypes change in the presence of absence of the virus. These results will be correlated with peripheral blood mononuclear cells and RNA sequencing analysis.
2. We are using the above patient samples to determine why some patients have liver biopsies showing persistent chronic hepatitis, even though they have supposedly been "cured" and have obtained systemic viral resistance (SVR).
3. We are using multi-spectral imaging and digital microscopy to phenotype and quantify lymphocytes, macrophages, and liver sinusoidal endothelial cells in patients with chronic liver disease, including HCV.