Faculty bio page2
Heather Stevenson-Lerner

Heather Stevenson-Lerner, MD, PhDAssistant Professor

Pathologist
Department of Pathology
Office: (409) 772-8554
hlsteven@utmb.edu
https://twitter.com/drhslovesliver

Heather Stevenson-Lerner, MD, PhD

My primary research focus is hepatic immunology and how dysregulation of the immune response leads to fibrosis development. I am also interested understanding how the phenotype of a person's hepatic macrophages determines downstream immune activation and how they respond to liver injury.

My laboratory is currently working on three main projects:

1. We are currently conducting a clinical study to better understand viral hepatitis C infection by collecting blood samples and liver biopsies in patients before and after treatment with the recently developed IFN-free antivirals. We are using multi-spectral imaging to analyze macrophages, lymphocytes, and liver sinusoidal endothelial cells, before and after treatment, and will use this technology to see how the various cell phenotypes change in the presence of absence of the virus. These results will be correlated with peripheral blood mononuclear cells and RNA sequencing analysis.

2. We are using the above patient samples to determine why some patients have liver biopsies showing persistent chronic hepatitis, even though they have supposedly been "cured" and have obtained systemic viral resistance (SVR).

3. We are using multi-spectral imaging and digital microscopy to phenotype and quantify lymphocytes, macrophages, and liver sinusoidal endothelial cells in patients with chronic liver disease, including HCV.

MD-PhD University of Texas Medical Branch at Galveston 2002-2009
Resident Anatomic and Clinical Pathology Residency, University of Texas Medical 2009-2013
Fellowship Fellowship, Liver and Transplantation Pathology, University of Pittsburgh Medical Center, Pittsburgh 2013-2014


Clinical focus

Anatomic and Clinical Pathology (AP-CP), Board Certified
Hepatopathology
Transplantation Pathology (heart, liver, kidney, pancreas, small intestine)
Gastrointestinal Pathology

June 2017 Awarded Anatomic Pathology Faculty of the Year by the Pathology Resident/Fellows Training Program, UTMB, Galveston, TX
September 2016 Nominated as UTMB's annual attendee to the nationally recognized Promoting Professionalism program held at Vanderbilt University, Nashville, TN
May 2016 Awarded Anatomic Pathology Lecturer of the Year for 2015-2016 by the Pathology Resident/Fellows Training Program, UTMB, Galveston TX
February 2016 University of Texas Systems Rising STARs Award, received prestigious funding award to obtain laboratory equipment, UT Systems, Austin, TX
Hans Popper Hepatopathology Society (HPHS)
American Association for the Study of Liver Diseases (AASLD)
Texas Society of Pathologists (TSP)
College of American Pathologists (CAP)
The United States & Canadian Academy of Pathology (USCAP)
American Association of Immunologists (AAI)
  1. Nguyen, J., Jiao, J., Smoot, K., Watt, G.P., Zhao, C., Song, X., Stevenson, H.L., McCormick, J.B., Fisher-Hoch, S.P., Futreal, A., Zhang, J., and L. Beretta. Toll-like receptor 4: a target for chemoprevention of hepatocellular carcinoma in obesity and steatohepatitis.  Oncotarget.
  2. Tayyem, O. Saraireh, Al Hanayneh, M., and H.L. Stevenson. A Heart Transplant Recipient with Mycophenolate Mofetil-Induced Colitis: The Great Imitator.  Accepted. 2018.
  3. Jiao, J., Watt, Gordon, P., Stevenson, H.L., Fisher-Hoch, S.P., Ye, Y., Wu, X., Vierling, J.M. Moore, and L. Beretta.  Telomerase Reverse Transcriptase Mutations in Plasma DNA in Patients with HCC or Cirrhosis: Prevalence and Risk factors. Hepatol comm. Apr 27;2(6):718-731. 2018.
  4. Moreno Prats, M., Sasatomi, E., and H.L. Stevenson.  Colorectal liver metastases: A pathologist’s guide to creating an informative report and improving patient care.  Arch path lab med. May 23. doi: 10.5858/arpa.2017-0505-RA. [Epub ahead of print]. 2018.
  5. Stevenson, H.L., Moreno Prat, M. Isse, K., and A.J. Demetris.  Isolated vascular “v” lesions in liver allografts: Approach to this puzzling finding. Amer. J.
  6. Booth, A.L., Osehobo, P., Rodgers-Soriano, D., Lalarukh, A., Eltorky, M.A., and H.L. Stevenson.Hemophagocytic lymphohistiocytosis secondary to unknown underlying Hodgkin’s lymphoma Presenting with a cholestatic pattern of liver injury. Case Rep Gastroenterol. 2018 Apr 24;12(1):99-108. 2018.
  7. Simões, C.C., Ghouri, Y.A., Merwat, S., and H.L. Stevenson. Budd-Chiari Syndrome: a rare and life-threatening complication of Crohn’s Disease. BMJ Case Rep. Jan 17;2018.
  8. Jiao, J., Weibo Niu, W. Wang, Y., Baggerly, K., Ye, Y., Wu, X., Davenport, D. Almeda, J.L., Stevenson, H.L., McCormick, J.B., Fisher-Hoch, S.P. and L. Beretta. Prevalence of aflatoxin-associated TP53 R249S mutation in HCC in Hispanics in South Texas. Cancer Prev Res (Phila). Feb;11(2):103-112. 2018.
  9. Jiao, J., González, Á., Stevenson, H.L., Gagea, M., Sugimoto, H., Kalluri, R., and L. Beretta.  Depletion of S100A4+ stromal cells doesn’t prevent HCC development but reduces the stemlike phenotype of the tumors. Exp mol Med. Jan 50(1):e422. 2018.
  10. W. Yoo, D. Gjuka1, Stevenson, H.L., X. Song, H. Shen1, S. Y. Yoo, J. Wang, M. Fallon, G. N. Ioannou, S. A. Harrison, & L. Beretta.  Fatty acids in non-alcoholic steatohepatitis: focus on pentadecanoic acid. Dec 15;12(12):e0189965. 2017.
  11. Pinkaew, D., Chattopadhyay, A., Zhihe, L., Stevenson H.L., Chen, Y., and K. Fujise. Fortilin binds IRE1a and prevents ER stress from signaling apoptotic cell death. Nat Commun. May 26;8(1):18. 2017.
  12. Booth, A.L., Boor, P., Al Dossari, G. and H.L. Stevenson. Abundant dystrophic calcifications mimicking aortic valve abscess in a patient undergoing elective aortic valve replacement. BMJ Case Rep. Jul 19 bcr-2017-220368. 2017.
  13. Jung, K., Yoo, W., Stevenson, H.L., Shen, H., Gagea, M., Yoo, S., Wang, J., Eckols, T.K., Bharadwaj, U., Tweardy, D.J., and L. Beretta. Multi-functional effects of a small-molecule STAT3 inhibitor on NASH and HCC growth. Clin Cancer Res. Sep 15;23(18):5537-5546. 2017.
  14. Shubhashish S., Popov, V. L., O’Connell, M.L., Stevenson, H.L., Lee, B., Duvalla, R. Obeid, R., Luthra, G., and P.  Singh. A novel cancer stem cell biomarker, DCLK1-S, traffics to nuclei of colon cancer cells, and may predict colon cancer risk of patients at time of index colonoscopy. Lab invest. Oct;97(10):1245-1261. 2017.
  15. Stevenson, HL., Moreno-Prats, M. and E. Sasatomi.  CD34, smooth muscle actin and glutamine synthetase as markers for chemotherapy-induced hepatic sinusoidal injury in patients with colorectal liver metastases. BMC Cancer. 17(1):35. 2017.
  16. Salameh, H., Johnson, J., Diab, K., Merwat, S., and H.L. Stevenson.  Autoimmune hepatitis-induced cirrhosis due to long-term methotrexate therapy for rheumatoid arthritis. Annals clin case reports: Hepatol. (12: 1122).  2016
  17. Stevenson, H.L., and N. Utay.  Hepatic Steatosis in HCV-Infected Persons in the Direct-Acting Antiviral Era. Trop Dis, Trav Med and Vac. 2:21. 2016.
  18. BANFF WORKING GROUP (includes Stevenson, H.L.), 2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-mediated Rejection. Amer J Trans. Oct;16(10):2816-2835. (PMID: 27273869).  2016.
  19. Chintamaneni, P., Stevenson, H.L. and S.M Malik, M.D. Bupivacaine Drug-induced liver injury: A case series and brief review of the literature. J. Clin. Anesth. 32, 137–141. 2016.
  20. Cicalese, L., Corsello, T., Stevenson, H.L., Damiano, G.  Tuveri, M., Zorzi, D., Montalbano, M., Shakfaran, N., and C. Rastellini.  Evidence of absorptive function in vivo in a neo-formed bio-artificial intestinal segment in a rodent model. J Gastrointest Surg. J Gastrointest Surg. 20(1):34-42; discussion 42. 2016.
  21. Yang, Q., Stevenson, H.L., Scott, M., and N. Ismail.  Type I IFN regulates non-canonical inflammasome activation and impairs protective immunity during fatal Ehrlichia -induced toxic shock.  Am J Pathol. 185(2):446-61. 2015.
  22. Petersen, J.R., Stevenson, H.L., Snyder, N., Kasturi1, K.,  Naniwadekar, A., Sampson, E., Parkes, J., and R. Cross.  Evaluation of the APRI (AST, platelet ratio index) and ELF™ (Enhanced Liver Fibrosis) tests to detect significant fibrosis due to chronic hepatitis C. J Clin Gastroenterol. 48(4):370-6. 2014.
  23. Stevenson, H.L., Amador, A., McCue, J., Ciancio, G., Chen L., Mattiazzi, A., Sageshima, J., Guerra, G., Roth, D., Kupin W., Burke G.W., Pham, S., Tzakis, A., and P. Ruiz. Mannose binding lectin (mbl2) haplotype frequencies in solid organ transplant patients and correlation with MBL protein levels – evaluation of complement-mediated effector pathway deficiency. Trans. Immunol. 28(2-3):73-80. 2013.
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