Pathology Post Doctoral Program Directory

Huang KaiKai Huang, MD, PhD

Office: (409) 772-2831

Kai Huang, MD

  1. Non-neutralizing antibody protective mechanisms against filovirus;
  2. Role of complement in virus infection;
  3. Evolution and molecular epidemiology of RNA viruses;
  4. Interspecies transmission and pathogenesis of highly virulent viruses;
  5. Antibody engineering.
Dr. Kai Huang got his M.D. in 2002 from Guangxi Medical University and Ph.D. in 2012 from University of Hong Kong, which is the WHO reference laboratory for H5N1 influenza diagnosis and the State Key Laboratory of Emerging Infectious Diseases. He worked as a postdoctoral associate at Cornell University Veterinary School thereafter and now a senior postdoctoral fellow in University of Texas Medical Branch.


  1. Robert Harrison Award given by University of Texas Medical Branch (Department of Pathology), 2019
  2. Top 1% Reviewers for cross-field ( given by Publons, 2019
  3. Top 1% Reviewers for Clinical Medicine ( given by Publons, 2018
  4. Top 1% Reviewers for Molecular Biology & Genetics ( given by Publons, 2018
  5. Postdoctoral Fellow Training Award (Award # HHSN272201400008C) given by National Institute of Health Centers for Excellence in Influenza Research & Surveillance (CEIRS), 2015
  6. Postdoctoral Fellow Travel Award for ASV meeting given by American Society for Virology, 2014
  7. Travel Award given by University of Hong Kong for Zoonotic Influenza and Human Health Conference in Oxford University UK, 2011
  • American Society for Virology
  • American Society for Microbiology
  • American Society for Tropical Medicine and Hygiene
  • International Association of Veterinary Editors
    1. Liam B King, Brandyn R West, Crystal L Moyer, Pavlo Gilchuk, Andrew Flyak, Philipp A Ilinykh, Robin Bombardi, Sean Hui, Kai Huang, Alexander Bukreyev, James E Crowe, Erica Ollmann Saphire (2019) Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk. Nat Commun 10, 1788
    2. J. Brian Kimble, Delphine C. Malherbe, Michelle Meyer, Bronwyn M. Gunn, Marcus M. Karim, Philipp A. Ilinykh, Mathieu Iampietro, Khaled S. Mohamed, Surendra Negi, Pavlo Gilchuk, Kai Huang, Yuri I. Wolf, Werner Braun, James E. Crowe, Galit Alter, Alexander Bukreyev (2019) Journal of Virology, 93 (4) e01845-18
    3. Gilchuk P, Kuzmina N, Ilinykh PA, Huang K, Gunn BM, Bryan A, Davidson E, Doranz BJ, Turner HL, Fusco ML, Bramble MS, Hoff NA, Binshtein E, Kose N, Flyak AI, Flinko R, Orlandi C, Carnahan R, Parrish EH, Bombardi RG, Sevy A, Singh PK, Mukadi P, Muyembe-Tamfum JJ, Ohi MD, Ollmann Saphire E, Lewis GK, Alter G, Ward AB, Rimoin AW, Bukreyev A, and Crowe JE Jr. (2018) Multifunctional pan-ebolavirus antibodies recognize a site of broad vulnerability on the ebolavirus glycoprotein. Immunity. 49 (2), 363-374. e10.
    4. Philipp A Ilinykh, Rodrigo I Santos, Bronwyn M Gunn, Natalia A Kuzmina, Xiaoli Shen, Kai Huang, Pavlo Gilchuk, Andrew I Flyak, Patrick Younan, Galit Alter, James E Crowe Jr, Alexander Bukreyev (2018) Asymmetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap. PLoS Pathog 14(8): e1007204
    5. Natalia A Kuzmina, Patrick Younan, Pavlo Gilchuk, Rodrigo I Santos, Andrew I Flyak, Philipp A Ilinykh, Kai Huang, Ndongala M Lubaki, Palaniappan Ramanathan, James E Crowe Jr, Alexander Bukreyev (2018) Antibody-dependent enhancement of Ebola virus infection by human antibodies isolated from survivors. Cell Reports 24(7), 1802-1815.e5
    6. Philipp A Ilinykh, Jessica Graber, Natalia A Kuzmina, Kai Huang, Thomas G Ksiazek, James E Crowe Jr, Alexander Bukreyev (2018) Ebolavirus Chimerization for the Development of a Mouse Model for Screening of Bundibugyo-Specific Antibodies, The Journal of Infectious Diseases, 218(s5) S418–S422
    7. I Andrew Flyak, Natalia Kuzmina, Charles D Murin, Christopher Bryan, Edgar Davidson, Pavlo Gilchuk, Christopher P Gulka, Philipp A Ilinykh, Xiaoli Shen, Kai Huang, Palaniappan Ramanathan, Hannah Turner, Marnie L Fusco, Rebecca Lampley, Nurgun Kose, Hannah King, Gopal Sapparapu, Benjamin J Doranz, Thomas G Ksiazek, David W Wright, Erica Ollmann Saphire, Andrew B Ward, Alexander Bukreyev, James E Crowe (2018) Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2–MPER region. Nat Microbiol 3, 670–677
    8. Heather Callaway, Kathrin Welsch, Wendy Weichert, Andrew Allison, Susan Hafenstein, Kai Huang, Sho Iketani, Colin Parrish (2018) Complex and dynamic interactions between parvovirus capsids, transferrin receptors and antibodies control cell infection and host range. Journal of Virology, 92 (13) e00460-18
    9. Liam B. King, Marnie L. Fusco, Andrew I. Flyak, Philipp A. Ilinykh, Kai Huang, Bronwyn Gunn, Robert N. Kirchdoerfer, Kathryn M. Hastie, Amandeep K. Sangha6, Jens Meiler, Galit Alter, Alexander Bukreyev, James E. Crowe, Jr., and Erica Ollmann Saphire (2018) The Marburgvirus-neutralizing human monoclonal antibody MR191 targets a conserved site to block virus receptor binding. Cell Host Microbe, 23 (1), 101-109.
    10. Brandyn R West, Anna Z Wec, Crystal L Moyer, Marnie L Fusco, Philipp A Illinykh, Kai Huang, Rebekah James, Andrew Herbert, Sean Hui, Ariel S Wirchnianski, Eileen Goodwin, M Javad Aman, Laura M Walker, John M Dye, Alexander Bukreyev, Kartik Chandran, Erica Ollmann Saphire (2018). Structural basis of broad Ebolavirus neutralization by a human survivor antibody. Nature Structural & Molecular Biology doi: 10.1038/s41594-019-0191-4
    11. Nogales, A., Rodriguez, L., Chauché, C., Huang, K., Reilly, E. C., Topham, D. J., ... & Martínez-Sobrido, L. (2017). Temperature-Sensitive Live-Attenuated Canine Influenza Virus H3N8 Vaccine. Journal of virology, 91(4), e02211-16
    12. Aitor Nogales, Kai Huang, Caroline Chauché, Marta L DeDiego, Pablo R Murcia, Colin R Parrish, Luis Martínez-Sobrido (2017) Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines. Virology, 500, 1-10
    13. Organtini, L. J., Lee, H., Iketani, S., Huang, K., Ashley, R. E., Makhov, A. M., ... & Hafenstein, S. (2016). Near-Atomic Resolution Structure of a Highly Neutralizing Fab Bound to Canine Parvovirus. Journal of virology, 90(21), 9733-9742.
    14. Feng, K.H., Gonzalez, G., Deng, L, Yu, H., Tse, V., Huang L., Huang K., Wasik B.R., Bin Zhou, David E. Wentworth,Edward C. Holmes, Xi Chen, Ajit Varki, Pablo R. Murcia and Colin R. Parrish. Equine and canine influenza H3N8 viruses show minimal biological differences despite phylogenetic divergence. Journal of virology 89(13):6860-73
    15. Dalziel, B. D., Huang, K., Geoghegan, J. L., Arinaminpathy, N., Dubovi, E. J., Grenfell, B. T., Ellner, S. P., Holmes, E. C., Parrish, C. R. (2014). "Contact Heterogeneity, Rather Than Transmission Efficiency, Limits the Emergence and Spread of Canine Influenza Virus." PLoS Pathog 10(10): e1004455.
    16. Huang, K., H. Zhu, X. Fan, J. Wang, C. L. Cheung, L. Duan, W. Hong, Y. Liu, L. Li, D. K. Smith, H. Chen, R. G. Webster, R. J. Webby, M. Peiris, and Y. Guan. 2012. Establishment and lineage replacement of h6 influenza viruses in domestic ducks in southern china. J Virol 86:6075-6083. 
    17. Duan, L., H. Zhu, J. Wang, K. Huang, C. L. Cheung, J. S. Peiris, H. Chen, and Y. Guan (2011). Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China. Influenza Other Respi Viruses 5 Suppl 1:65-68. 
    18. Huang, K., J. Bahl, X. H. Fan, D. Vijaykrishna, C. L. Cheung, R. J. Webby, R. G. Webster, H. Chen, G. J. Smith, J. S. Peiris, and Y. Guan. 2010. Establishment of an H6N2 influenza virus lineage in domestic ducks in southern China. J Virol 84:6978-6986. 
    19. K Huang, CL Cheung, X Fan, H Zhu, J Wang, L Duan, R Webby, RG Webster, H Chen, JSM Peiris, Y Guan
    20. Zengfeng Zhang, Jinxia Zhang, Kai Huang, Kang-Sheng Li, Kwok-Yung Yuen, Yi Guan, Honglin Chen, Wai Fu Ng (2009). Systemic infection of avian influenza A virus H5N1 subtype in humans. Human Pathology 40(5): 735-739. 
    21. Smith, G. J., D. Vijaykrishna, T. M. Ellis, K. C. Dyrting, Y. H. Leung, J. Bahl, C. W. Wong, Huang K., M. K. Chow, L. Duan, A. S. Chan, L. J. Zhang, H. Chen, G. S. Luk, J. S. Peiris, and Y. Guan. 2009. Characterization of avian influenza viruses A (H5N1) from wild birds, Hong Kong, 2004-2008. Emerg Infect Dis 15:402-407. 
    22. Duan, L., J. Bahl, G. J. Smith, J. Wang, D. Vijaykrishna, L. J. Zhang, J. X. Zhang, K. S. Li, X. H. Fan, C. L. Cheung, K. Huang, L. L. Poon, K. F. Shortridge, R. G. Webster, J. S. Peiris, H. Chen, and Y. Guan. 2008. The development and genetic diversity of H5N1 influenza virus in China, 1996-2006. Virology 380:243-254. 
    23. Zhang, Z. F., X. H. Fan, K. S. Li, K. Huang, D. Z. Luo, Z. B. Feng, M. Y. Wei, Y. Guan, H. L. Chen, and J. X. Zhang. 2008. Prevalence of Avian Influenza Virus Receptor in Human Respiratory Tract. Prog Biochem Biophys 35:1387-1393. 
    24. Cheung, C. L., D. Vijaykrishna, G. J. Smith, X. H. Fan, J. X. Zhang, J. Bahl, L. Duan, K. Huang, H. Tai, J. Wang, L. L. Poon, J. S. Peiris, H. Chen, and Y. Guan. 2007. Establishment of influenza A virus (H6N1) in minor poultry species in southern China. J Virol 81:10402-10412. 
    25. L. Duan, L. Campitelli, X. H. Fan, Y. H. C. Leung, D. Vijaykrishna, J. X. Zhang, I. Donatelli, M. Delogu, K. S. Li, E. Foni, C. Chiapponi, W. L. Wu, H. Kai, R. G. Webster, K. F. Shortridge, J. S. M. Peiris, Gavin J. D. Smith, H. Chen, Y. Guan. (2007) Characterization of Low-Pathogenic H5 Subtype Influenza Viruses from Eurasia: Implications for the Origin of Highly Pathogenic H5N1 Viruses. Journal of Virology Jun 2007, 81 (14) 7529-7539
    26. Smith, G. J., X. H. Fan, J. Wang, K. S. Li, K. Qin, J. X. Zhang, D. Vijaykrishna, C. L. Cheung, K. Huang, J. M. Rayner, J. S. Peiris, H. Chen, R. G. Webster, and Y. Guan. 2006. Emergence and predominance of an H5N1 influenza variant in China. Proc Natl Acad Sci U S A 103:16936-16941. 
    27. Chen, H., G. J. Smith, K. S. Li, J. Wang, X. H. Fan, J. M. Rayner, D. Vijaykrishna, J. X. Zhang, L. J. Zhang, C. T. Guo, C. L. Cheung, K. M. Xu, L. Duan, K. Huang, K. Qin, Y. H. Leung, W. L. Wu, H. R. Lu, Y. Chen, N. S. Xia, T. S. Naipospos, K. Y. Yuen, S. S. Hassan, S. Bahri, T. D. Nguyen, R. G. Webster, J. S. Peiris, and Y. Guan. 2006. Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control. Proc Natl Acad Sci U S A 103:2845-2850. 
    28. Huang, K., and X. H. Fan. 2005. The Pathogenesis and possible nascence for new emerging highly virulent H5N1 influenza virus. Guangxi Journal of Preventive Medicine 2:122-124. 
    29. Hou X., Fan X., Huang Q, Huang K. Measurement and significance of sFAS in the patients with hepatocellular carcinoma. Journal of Guangxi Medical University. 2004, 21 (2):205-206. 

    Conferences & Presentations

    1. July 14-18, 2018, 37th Annual meeting of American Society of Virology, Maryland, USA  (Oral presentation)
    2. Jul 11-15, 2015, 34th Annual meeting of American Society of Virology, London ON, Canada (Oral presentation)
    3. Jun 21-25, 2014, 33rd Annual meeting of American Society of Virology, Colorado, USA (Poster presentation)
    4. Dec 9, 2011, Frontiers in BioMedical Research, Hong Kong
    5. Sep 7-9, 2011, The 4th Oxford influenza conference, Influenza 2011. Oxford University, United Kingdom. (Oral presentation)
    6. Dec 3, 2010, Frontiers in BioMedical Research, Hong Kong
    7. Dec 1-2, 2010, 15th Research Postgraduate Symposium, Hong Kong (Oral presentation)
    8. Oct 6, 2010, Area of Excellence, Control of Pandemic and Inter-Pandemic influenza, Hong Kong (Oral presentation)
    9. Sep 3-7, 2010, Options for the Control of Influenza VII, Hong Kong (Oral presentation)
    10. Dec 4, 2009, Frontiers in BioMedical Research, Hong Kong 
    11. Dec 12, 2008, Frontiers in BioMedical Research, Hong Kong 
    12. Dec 10-11, 2008, 13th Research Postgraduate Symposium, Hong Kong (Poster presentation)
    13. Dec 2007, Frontiers in BioMedical Research, Hong Kong

    GenBank Contribution

    Full genome - 467 viruses, Partial - 16 viruses

    GenBank Accession numbers: HM144388-HM145740, CY109223-CY110734, KM359803-KM359864

    Review & Editorial Experience