My research focuses on understanding of immune response to West Nile virus infection in protection and pathogenesis. West Nile virus, a vector-borne pathogen, has resulted in annual outbreaks of viral encephalitis in North America since 1999. Using a murine infection model, my current work explores immune factors contributing to the development of long-lasting protective immunity against West Nile virus. Aging is a known risk factor for West Nile virus induced encephalitis. The decline in immunity seen in the elderly is one of the significant contributors to the increased risk of infection. My lab also studies whether the dysfunction of immune factors in aged mice leads to a defective adaptive immunity.