Faculty bio page2
Jere W. McBride, PhD

Jere W. McBride, MS, PhDProfessor

Departments of Pathology and Microbiology & Immunology
Center for Biodefense and Emerging Infectious Diseases
Director, Experimental Pathology Graduate Program
Member, Center for Biodefense and Emerging Infectious Diseases
Scientist, Sealy Institute for Vaccine Sciences
Member, Institute for Human Infections and Immunity
Phone: (409) 747-2498
Email: jemcbrid@utmb.edu
UTMB Influuent webpage

Jere W. McBride, PhD

  • Obligately intracellular bacteria-host interactions
  • Molecular mimicry by intracellular bacteria
  • Post translational modifications and host-pathogen interactions
  • Pathogen encoded ubiquitin ligases and host cell substrates
  • Exploitation of conserved host cell signaling pathways for infection
  • Modulation of host transcription and epigenetics by intracellular bacteria
  • Innate and adaptive immunity to obligates
  • Human and veterinary diagnostics, vaccines and therapeutics for the ehrlichioses

Current research

Ehrlichia spp. are obligate intracellular bacteria that have evolved sophisticated molecular mechanisms to survive in phagocytes, and thus are an excellent model system to study interkingdom molecular interactions between prokaryotes and eukaryotes involved in infection and immune evasion. Ehrlichiae have very small genomes and infect and survive in professional phagocytes by activating and modulating host cell signaling pathways inhibit host defense mechanisms, and by reprogramming host cell gene transcription through nucleomodulin effectors that bind host DNA to modulate host gene transcription.  The research focus of Dr.McBride’s laboratory is in four areas, 1) understanding the role of post translational modificiations in pathogen-host interactions, 2) revealing how ehrlichiae exploit conserved host cell pathways to subvert innate host defense mechanisms, 3) defining the molecular basis and mechanisms of humoral immunity to intracellular bacteria, and 4) development of subunit vaccines, immunodiagnostics and therapeutics for the ehrlichioses. Through our investigations, we have defined ehrlichial type 1 effectors instrumental in a cellular reprogramming strategy, identified novel molecular effector‐host interactions with conserved host cell pathways to subvert innate host defense mechanisms, defined ehrlichial nucleomodulins that target host cell genes and reprogram host cell gene transcription. In translational areas of research, our laboratory has defined immunoprotective proteins/epitopes, identified novel mechanisms of antibody-mediated immunity, developed immunodiagnostics, subunit/chimeric vaccines and novel therapeutics for the ehrlichioses.
BS Louisiana State University, Baton Rouge Microbiology 1987
MS Louisiana State University, Baton Rouge Microbiology/Immunology 1993
PhD University of California, Davis Comparative Pathology 1997
Fellowship University of Texas Medical Branch Cellular Microbiology 1999
Editorial Board, Infection and Immunity
1999 James W. McLaughlin Award for Research Excellence in Infection and Immunity, University of Texas Medical Branch
1999 Postdoctoral Award for Molecular/ Cell Biology Research, Department of Pathology, Pathology Trainee Research Session University of Texas Medical Branch
2004 Experimental Pathology Graduate Student Award for Teaching and Mentoring, University of Texas Medical Branch
2004 Department of Pathology nominee for the W.M. Keck Foundation Distinguished Young Scholars in Medical Research Award
2009 Department of Pathology, Researcher of the Year
  • American Society for Microbiology
  • American Society for Investigative Pathology
  • American Society for Rickettsiology
  1. Lina T, Lou T, Velayutham T, McBride JW. Ehrlichia activation of Wnt-PI3K-mTOR signaling inhibits autolysosome generation and autophagic destruction by the mononuclear phagocyte. Infect. Immun. 2017 Oct 9. pii: IAI.00690-17. doi: 10.1128/IAI.00690-17. PMID 28993455.
  2. Lina TT, Dunphy PS, Luo T, McBride JW.  Ehrlichia chaffeensis TRP120 activates canonical Notch signaling to downregulate TLR2/4 expression and promote intracellular survival. mBio 2016; 7: e00672-16 PMCID: PMC4958247
  3. Dunphy PS, Luo T, and McBride JW.  Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival.  Infect. Immun.  2014; 82:4154-68.  PMCID: PMC4187855 (Selected by the editors as an article of significant interest-“Spotlight” p.3989).
  4. Luo T, Dunphy PS, Lina TT, McBride JWEhrlichia chaffeensis exploits canonical and noncanonical host Wnt signaling pathways to stimulate phagocytosis and promote intracellular survival.  Infect. Immun. 2016; 84:686-700. PMCID: PMC4771358 (Selected by the editors as an article of significant interest-“Spotlight” p.611).
  5. Zhu B, Nethery KA, Kuriakose JA, Zhang, XF, and McBride JW.  Nuclear translocated Ehrlichia chaffeensis ankyrin repeat protein interacts with the mid-A stretch of host promoter and intronic Alu elements.  Infect Immun 2009; 77:4243-4255. (Selected by the editors as an article of significant interest-“Spotlight” p.4181) PMCID: 2747939
  6. Zhu B, Kuriakose JA, Luo T, Ballesteros E, Gupta S, Fofanov Y, and McBride JWEhrlichia chaffeensis TRP120 bind a G+C-rich motif in host cell DNA and exhibits eukaryotic transcriptional activator function.  Infect. Immun. 2011; 79:4370-4381. PMCID: 3257946
  7. Mitra S, Dunphy PS, Das S, Zhu B, Luo T, McBride JW. Ehrlichia chaffeensis TRP120 effector targets and recruits host polycomb group proteins for degradation to promote intracellular infection.  Infect. Immun. 86:e00845-17. PMID 29358333.
  8. Farris TR, Dunphy PS, Zhu B, Kibler CE, and McBride JW. Ehrlichia chaffeensis TRP32 is a nucleomodulin that directly regulates expression of host genes governing differentiation and proliferation.  Infect. Immun.  2016; 84: 3182-3194. Aug 29. pii: IAI.00657-16 (Selected by the editors as an article of significant interest-“Spotlight” p.3093).  PMCID: PMC 5067751.
  9. Luo T, Zhang XF, Wakeel A, Popov VL, and McBride JW.  Variable-length PCR target protein of Ehrlichia chaffeensis contains major species-specific antibody epitopes in highly acidic serine-rich tandem repeats. Infect. Immun.  2008; 76:1572-1580. PMCID: 2292866
  10. McBride JW, Zhang XF, Wakeel A, and Kuriakose J. Tyrosine phosphorylated Ehrlichia chaffeensis and E. canis tandem repeat orthologs contain a major continuous cross-reactive antibody epitope in lysine-rich repeats. Infect. Immun. 2011; 79:3178-3187. PMCID: 3147547
  11. Kuriakose J, Zhang XF, Luo T and McBride JW.  Molecular basis of antibody mediated immunity to Ehrlichia chaffeensis involves species-specific linear epitopes in tandem repeat proteins. Microbes Infect. 2012; 14:1054-63. PMCID: 3445803
  12. McBride JW and Walker DH.  2010.  Progress and Obstacles in Vaccine Development for the Ehrlichioses. Expert Reviews of Vaccines. Review. 9:1071-1082. PMCID: 2951016
  13. McBride JW, Ndip L, Popov VL, Walker DH.  Identification and functional analysis of an immunoreactive DsbA-like thio-disulfide oxidoreductase of Ehrlichia spp.  Infect Immun. 2002; 70:2700-2703. PMCID: 127935
  14. Doyle CK, Zhang X, Popov VL, McBride JW.  An immunoreactive 38-kilodalton protein of Ehrlichia canis shares structural homology and iron-binding capacity with the ferric-ion binding protein family. Infect Immun. 2005; 73:62-69. PMCID: 538948
  15. Zhu B, Das S, Mitra S, Farris TR, McBride JW. Ehrlichia chaffeensis TRP120 moonlights as a HECT E3 Ligase involved in self- and host ubiquitination to influence protein interactions and stability for intracellular survival.  Infect. Immun. 2017 85:1-16 pii: e00290-17. doi: 10.1128/IAI.00290-17  PMID 28630068.
  16. Wakeel A, Kuriakose J, and McBride JW.  An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation and vesicle trafficking. Infect. Immun.  2009; 76:1572-1580.  (Selected by the editors as an article of significant interest-“Spotlight” p.1721) PMCID: 2681728
  17. Luo T and McBride JW.  Ehrlichia chaffeensis TRP32 interacts with host cell targets that influence intracellular survival.  Infect. Immun. 2012; 80:2297-2306.  PMCID: 3416477
  18. Luo T, Kuriakose KA, Zhu B, Wakeel A, and McBride JW.  Ehrlichia chaffeensis TRP120 interacts with a diverse array of eukaryotic proteins involved in transcriptional regulation, signaling, and cytoskeleton organization. Infect. Immun. 2011; 79:4382-4391. PMCID: 3257936
  19. Wakeel A, den Dulk-Ras A, Hooykas PJJ, McBride JW. Ehrlichia chaffeensis tandem repeat proteins are type 1 secretion system substrates related to the repeats-in-toxin exoprotein family.  Front. Cell. Infect. Microbio. 2011; 1:1-19.  PMCID: 3417381

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