Faculty bio page2
Saravanan Thangamani, MSc, PhD

Saravanan Thangamani, MSc, PhDAssociate Professor

Department of Pathology
Vice-Chair, Institutional Animal Care and Use Committee (IACUC)
Director, Arthropod Containment Laboratories (ACL-3/-2)
Director, Insectary Services Core
Director, Tick Vector Biology Program
Cell: (409) 771-7193
Office: (409) 747-2412
Lab: (409) 747-2415
Email: sathanga@utmb.edu
Website: thangamani-lab.com

Vidarshi Muthukumarana, MD

Fine needle aspiration cytology
MBBS University of Colombo, Sri Lanka Medicine 2009
Danbury Hospital, Connecticut Anatomic and surgical pathology 2013 - 2017
Memorial Sloan Kettering Cancer Center, New York Oncologic surgical pathology 2017-2018
Baylor College of Medicine, Houston Texas Cytopathology 2018-2019
College of American Pathologists (CAP)
American Society of Clinical Pathology (ASCP)
United States and Canadian Academy of Pathology (USCAP)
American Society of Cytopathology (ASC)
Texas Society of Pathologists (TSP)
  • Russell body gastro-enterocolitis in a post-transplant patient: A case report and review of literature. Muthukumarana P, Segura S, O’ Brien M, El-Fanek H, Siddiqui R. Int J Surg Pathol 2015 Dec 26;23(8):667-72.
  • Primary hepatic neuroendocrine carcinoma: Case report and review of literature. Segura, MD, Vidarshi Muthukumarana, MD; Jeffrey West MD, Nusrat Pathan, MD. Conn Med. 2016 Jan;80(1):19-23.
  • Adrenocortical oncocytoma with borderline malignant potential causing subclinical cushing's syndrome Richa Bhattarai MD, Robert R Savino DO, Bidur Dhakal MD, Andrew McGregor MD, Daniel E Kleiner MD, Vidarshi Muthukumarana MD, Ramapriya Vidhun MD. AACE Clinical Case Reports: Winter 2017, Vol. 3, No. 1, pp. e46-e50.
  • Effusive-Constrictive Pericarditis Secondary to Malignant Pericardial Mesothelioma Rajesh Tota-Maharaj, Salma Baksh, Amrit Thakoor, Vidarshi Muthukumarana, Jessica Dodge, Amirhossein Mahfoozi, Ira Galin, Hal Wasserman. Journal of the American College of Cardiology – March 2015, Volume 65, Issue 10_S, March 2015

David G. Brust, MD

Cellular therapies including chimeric antigen receptor T cell immunotherapy and oncolytic viruses utilizing next generation CRISPR/Cas9 gene editing technologies.
National Institutes of Health Fellowship Transfusion Medicine 2019
Wake Forest University Residency Anatomic and Clinical Pathology 2017
Louisiana State University Residency Emergency Medicine 2006
Eastern Virginia Medical School Medical Doctorate Doctor of Medicine 2002
University of Richmond Bachelor of Arts Biology/PreMed major, chemistry minor 1995

Speaker, National Institutes of Health, 37th Annual Immunohematology and Blood Transfusion Symposium “A Challenging Case of an Exceptionally Rare Antibody”

2018

Speaker, American Association of Blood Banks Latin Section for Cellular Therapy “Next Generation Chimeric Antigen Receptor T-Cell Immunotherapy”

2018

Speaker, 40th Annual Conference of the American Society for Apheresis, Plenary Session Presentation “The Effect of Hydroxyethyl Starch on Renal Function in Long Term Granulocyte Donors”

2019

Speaker, 40th Annual Conference of the American Society for Apheresis, Poster Presentation “The Effect of Repeated Dexamethasone Administration on Bone Mineral Density in Long Term Granulocyte Donors”

2019

American Association of Blood Banks 2019 - Present
American Society for Therapeutic Apheresis 2019 - Present
American Board of Pathology 2017 – Present
North Carolina Society for Pathologists 2016 – Present
American Society for Clinical Pathology 2013 - Present
Brust D, Wu K, West K, Yau Y, Scinto T, Sun J, Natanson C, Klein H, Cantilena C. “The effect of hydroxyethyl starch on renal function in long term granulocyte donors.” In process.

Brust D, Wu K, Scinto T, Yau Y, Reynolds J, West K, Cantilena C. “The effect of repeated dexamethasone administration on bone mineral density in long term granulocyte donors.”  In process.

Brust D, Feden J, Farnsworth J, Amir C, Broaddus WC, Valerie K. “Radiosensitization of rat glioma with bromodeoxycytidine and adenovirus expressing herpes simplex virus-thymidine kinase delivered by slow, rate-controlled positive pressure infusion.” Cancer Gene Ther. 2000 May;7(5):778-88. DOI 10.1038/sj.cgt.7700168 PubMed PMID: 10830725.

Valerie K, Brust D, Farnsworth J, Amir C, Taher MM, Hershey C, Feden J. “Improved radiosensitization of rat glioma cells with adenovirus-expressed mutant herpes simplex virus-thymidine kinase in combination with acyclovir.” Cancer Gene Ther. 2000 Jun;7(6):879-84. DOI 10.1038/sj.cgt.7700185 PubMed PMID: 10880018.

Irma (Lisa) Cisneros, PhD

The overarching goal of the Cisneros Lab is to understand the mechanisms dictating interactions between the immune system and nervous system during substance use disorders and neuroinfectious diseases. Increasing evidence demonstrates that the immune system plays a critical role in both normal and pathological processes in the central nervous system. A particular interest is on immunocompetent cells of the CNS, including astrocytes and microglia, and their innate immune responses, both inflammatory and antiviral during substance use disorders and CNS viral infections. Using in vivo, ex vivo and in vitro models, we focus on neuroimmune interactions in addiction and viral-mediated neurodegeneration.

  1. Opioid self-administration, impulsivity and CNS innate immunity: The Centers for Disease Control reported that approximately 60,000 deaths in the United States were attributable to the misuse of illicit and prescription opioids in the 12-month period ending in September 2017. The intertwined misuse of prescription opioids with the emergence of extremely potent fentanyl derivatives has triggered even greater concerns in the nation. In the absence of overdose deaths, the incidence of repeated opioid overdose events indicates a problematic use pattern consistent with the development of the medical condition of opioid use disorder (OUD). Dysregulation of the brains higher order circuits is fundamentally involved in the progressive behavioral changes that promote OUD and relapse, specifically through structural, functional and molecular alterations and adaptations in the prefrontal cortex (PFC) and nucleus accumbens (NAc). Increasing evidence suggest that neuroimmune signaling forms a vital role in the neuropathology and behavioral indicators of OUD. Peripherally derived immune factors may influence increased cytokine expression, reactive gliosis, antigen-presentation markers and NF-kB transcriptional activity within the PFC and NAc, profoundly influencing neuroplasticity that reinforces OUD. Therefore, we are evaluating changes in neuroimmune markers in various brain regions and in the periphery following fentanyl self-administration. We hope to uncover the relationship of fentanyl and/or heroin self-administration and immune function because the host immune response is critical to address future translational aspects of vaccine development and the host immune response to viral infection
  2. Cocaine and regulation of astrocyte mitochondrial antiviral signaling (MAVS) protein during CNS viral infection: Cocaine is the second highest used illegal drug in the US, decreasing the users ability to fight off infections and increasing the severity and onset of HIV-1-mediated neuroinvasion and neurotoxicity, mechanisms likely to exacerbate ZIKV-mediated neurotoxicity as well. Astrocytes are the first line of defense against neurotoxicity associated with cocaine abuse and invading pathogens, becoming activated and initiating a robust innate immune response to pathogens.Astrocyte release of proinflammatory cytokines, upon cocaine treatment is well documented, however; the molecular mechanisms and regulation of cocaine on antiviral responses, thereby impacting HIV-1-induced innate immunity, remains elusive. Our preliminary data, in human astrocytes infected with human immunodeficiency virus-1, (HIV-1, retrovirus) and infected with Zika virus (ZIKV, neurotrophic ssRNA virus), demonstrates that cocaine alone does not increase astrocyte inflammatory responses, but robustly increases IFNb alone, suggesting activation of interferon response factor (IRF) signaling. Interestingly, we observed cocaine-mediated regulation of astrocyte oxidative stress, mitochondrial fission/fusion proteins, membrane permeability, IRF3 signaling and neuroinflammatory changes with antioxidants; which are outcomes identified to regulate mitochondrial antiviral signaling(MAVS) protein function, a mitochondrial scaffolding protein that initiates IRF and NF-kB signaling via recruitment of TNF associated factor (TRAF) proteins. Lastly, cocaine reduces cleavage of astrocyte MAVS and increases aggregation of MAVS in normal human astrocytes (NHA), which is reported to result in a preferential activation of IRF signaling and decreased NF-kB signaling. Astrocyte MAVS regulation by cocaine is highly significant, in that it may dictate the balance of viral-induced activation of astrocyte innate immune responses having larger implications in innate immune responses to CNS viral infections during cocaine use.
  3. HIV-1 and cocaine astrocyte-induced innate immunity: AIM(2)ing at the inflammasome: Astrocytes are the first line of defense during cocaine abuse and HIV-1, initiating a robust innate immune response. Mitochondrial antiviral signaling protein (MAVS), together with absent in melanoma 2 (AIM2)-like receptor inflammasomes, regulate inflammatory and antiviral signaling. Our preliminary data shows that repeated exposure of astrocytes to cocaine (10 mM), increases proinflammatory cytokines and decreases type I interferons (IFNs); contrary to results occurring subsequent to transient cocaine exposure, which does not influence proinflammatory cytokines and increases type I IFNs. Moreover, transient cocaine exposure triggers dose-dependent increases of reactive oxygen species (ROS), [Ca+2]i and mitochondrial damage, outcomes reported to regulate MAVS activation. Repeated cocaine exposure or HIV-1 treatments alone or with cocaine, increase dsDNA; a product that initiate MAVS and AIM2 signaling. The relationship between MAVS and AIM2 is not identified; however, MAVS promotes inflammasome activation via TNF associated factor (TRAF)3 ubiquitination of adaptor apoptosis-associated specklike protein (ASC). Furthermore, ASC inhibits MAVS ability to induce antiviral signaling through CARD-CARD homotypic interactions. MAVS-induced antiviral signaling is regulated by cleavage and aggregation, dictating downstream interactions and differentially activating NFkB and IFN response factor (IRF) signaling. Repeated cocaine exposure decreases MAVS signaling and increases MAVS aggregation, suggesting cocaine impacts MAVS functional capacity. AIM2 positively correlates with IFNb levels induced by cocaine, suggesting cocaine-induced IFNb, regulates AIM2 transcription, which is an IFN stimulated gene. Lastly, astrocytes transfected with siMAVS, reduced IFNb and AIM2 levels following cocaine exposure, compared to Mock and siCON-transfected astrocytes treated with cocaine. We hope to uncover the interactions between MAVS and AIM2 signaling in regulating innate immune responses during substance use disorders and HIV-1 CNS infection.
  4. Behavioral characterization of animal models of disease: We are characterizing the onset and severity of altered animal behavior and Alzheimer’s disease pathology in genetically modified animals following viral infection.More viruses are identified to enter the central nervous system, but we do not know how they may increases susceptibility to neurological disorders.Using TC-83 as our viral model, we will evaluate viral infection of the brain on the development of Alzheimer’s, this will provide us with knowledge on the role of inflammation on Alzheimer’s disease progression. Our studies are aimed at evaluating hippocampus-selective learning and memory performance in mice that represent models of neurodegenerative diseases at different ages. Our aim is to identify neurological infection/disease and associated alterations to behavior following TC-83 inoculation.
BS University of Texas at Brownsville Biology 2007
PhD University of North Texas Health Science Center Cellular Neuroimmune Pharmacology 2015
Postdoc University of Texas Medical Branch Addiction Research and Neuroinfectious Disease 2019
E. Fitzgerald Sporar Endowment Travel award 2019
ECOR Department of Pathology Pilot Funding 2019
Invited participant, American College of Neuropsychopharmacology Conference, 2018
Postdoctoral Poster Award, Pathology Research Day 2018
Invited speaker, “Impact of Substance Abuse on Neuroimmune Function,” SNIP/ISNV 2018
NIDA F32, Postdoctoral Recipient,  University of Texas Medical Branch, Galveston, TX 2018
Invited speaker, University of California San Diego (UCSD) 2018
Postdoctoral Extramural Research Service Award, UTMB 2017
NIH/NINDS BRAINS Fellow & Participant, Bainbridge Island, WA 2017
NIH Future Leaders Conference Fellow & Participant 2016
NIDA T32, Postdoctoral Recipient, University of Texas Medical Branch 2016
NIH/NIDA Diversity Scholars Network Fellow 2016
Translational Research Seminar Speaker, University of Texas Rio Grande Valley (UTRGV) 2016
Key Note Speaker, MBRS-RISE Induction Ceremony, UTRGV 2016
2nd Place poster presentation, Society for Neuroimmune Pharmacology 2015
Travel Award Recipient, Society for Neuroimmune Pharmacology, Miami, FL 2015
Dean’s Award for Achievement in Academic Excellence, UNTHSC 2015
Outstanding Graduate Student in Cell Biology and Immunology, UNTHSC 2014-2015
F31 Fellowship Recipient, NIH/NIDA, 2014-2015
Travel Award Recipient, Society for Neuroimmune Pharmacology 2014
Certificate of Excellence, Society for Neuroimmune Pharmacology, San Juan, PR 2013
Invited Student Member, American Association for the Advancement of Science 2012-2015
Institute for Aging and Alzheimer’s Disease Research (IAADR) Associate Fellow 2011-2012
Initiative to Maximize Student Development – Minority Biomedical Research Support (IMSD-MORE) 2009-2011
Recognition of Outstanding Research in Marine Biology, NOAA and Cea-CREST 2007
First Place poster presentation, University of Texas at Brownsville 2006
Minority Biomedical Research Support – Research Initiative for Scientific Enhancement (MBRS-RISE) Fellowship Award, University of Texas at Brownsville, 2005-2007
Society for Neuroscience 2019-2020
Sigma Xi 2015-2018
Society for the Advancement of Chicanos and Native Americans in Science (SACNAS) 2013-2019
American Society for Microbiologists 2013-2017
National Hispanic Science Network on Drug Abuse 2012-2019
American Association for the Advancement of Science, Student Member 2012-2015
Society for Neuroimmune Pharmacology 2010-2019
Cisneros IE; Erdenizmenli M; Cunningham KA; Paessler S; Dineley KT. Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes. Neuropharmacology, Feb 2018. Doi: 10.1016/j.neuropharm.2018.03.019
Dimet, AL*, Cisneros IE*, Fox RG, Stutz SJ, Anastasio NC, Cunningham KA, Dineley KT. Measuring Cue Reactivity in a Cocaine Self-Administration Rat Model, Journal of Visualized Experiments, 2017. Share first authorship.
Cisneros IE, Ghorpade A. Methamphetamine and HIV-1-induced neurotoxicity: Role of trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology, 2014 Oct;85:499-507. Doi:10.1016/j.neuropharm.2014.06.01 PMID: 24950453.
Fields J, Cisneros IE, Ghorpade A. Extracellular regulated kinase ½ signaling is a critical regulator of interleukin-1B-mediated astrocyte tissue inhibitor of metalloproteinase-1 expression. PLos One.  2013; 8(2):e56891. Published online 2013 February 14.doi:10.1371/journal.pone.0056891 PMCID: PMC3572966.
Cisneros IE, Ghorpade, A. HIV-1, Methamphetamine and Astrocyte Glutamate Regulation: Combined excitotoxic implications for Neuro-AIDS, Current HIV Research. 2012 May 11. PMID: 22591363. PMCID: PMC3580828.

ExPath Program Faculty

Ami Murphy, DO

BS Angelo State University,
San Angelo, TX
Mathematics 2000
MPH Florida State University,
Tallahassee, FL
Public Health 2005
DO University of North Texas Health Science Center – Texas College of Osteopathic Medicine,   2012
  University of Texas Medical Branch, Galveston, TX Anatomic Pathology Residency 2015
  Harris County Institute of Forensic Sciences, Houston, TX Forensic Pathology Fellowship 2016
  Certification Anatomic Pathology  
  Certification Forensic Pathology  
  Licensure State of Texas, Q8756 Exp: 08/31/2020
Photographer of the Year, University of Texas Medical Branch, Department of Pathology Residency Program 2015
Excellence in Teaching Award, University of Texas Medical Branch, Department of Pathology Residency Program 2013
University Fellowship Scholarship, Florida State University 2004, 2005

Texas Medical Association
Texas Society of Pathologists

Teaching/Lectures:

“Introduction to Forensics”, Hitchcock High School, April 2019

“Topics in Forensic Pathology”, Justice of the Peace/Law Enforcement Workshop, Longview, TX, August 2018

“Ethics in Forensic Pathology”, Lamar University, March 2017

“Forensics Cases”, American Osteopathic College of Pathologists Live Webinar Series, June 2016

“Serotonin Syndrome: Too Much of a Good Thing”, Harris County Institute of Forensic Sciences, 2013

“Forensic Pathology Workshop”, Girl Scouts of San Jacinto Council, 2013

Poster Presentations and Abstracts:

“Synthetic Cannabinoids and Mitragynine Abuse Presenting as Pseudo-diffuse Pulmonary Hemosiderosis”, poster presentation, Texas Society of Pathologists 2015 annual meeting

“Comparison of loop-mediated isothermal amplification, real-time PCR, and enzyme immunoassay methods for toxigenic Clostridium difficile detection”, poster presentation, Texas Society of Pathologists 2013 annual meeting.  Winner, second place overall

“Infantile Hemangioma”, poster presentation, University of North Texas Health Science Center – TCOM 2011 Research Appreciation Day.  Winner, first place in Children’s Health Research 

Residency Advisory Committee

Residency Admissions Committee

Residency Directory

Peter McCaffrey, MD

Machine Learning, Artificial Intelligence, Biomedical Informatics, Computational Biology.

BA

Southern Methodist University

Philosophy, English

2009

MD

The Johns Hopkins University School of Medicine

Doctor of Medicine

2014

Residency

Harvard Medical School, The Massachusetts General Hospital

Clinical Pathology

2017

Chief Residency

Harvard Medical School, The Massachusetts General Hospital

Clinical Pathology

2016

Fellowship

Texas Medical Center

Biodesign

2018

Board Certification

American Board of Pathology

Clinical Pathology

2018

Partners Healthcare Innovation Discovery Award

2016

1st Place Medical Capital Innovation Competition

2018

Most Outstanding Lecturer in Clinical Pathology

2019

Announcements

Nominations to recognize an individual who is a shining star within the research enterprise are due no later than Noon, Thursday 11/15/2018.

The CRO office will review the nominations and select a recipient to be announced at the upcoming Research Quarterly Update.  We will notify the winners vice chair the week of 11/19 so that they will be prepared to facilitate the Kudos and Highlight portion of the meeting.

Link to Nomination Form:
 https://research.utmb.edu/EOQNomination
Please contact Mary Jo D. Singleton for website design services.

Residents at Social Events

2018-2019 Residents and Fellows Goofing around on picture day
2018 Graduation Dinner
Baby Shower for Maria
Catching flounders outside the hospital
Dickens on the Strand. We even ran into some of our festive faculty.
Galveston Island Brewery is our favorite.
More fun at Galveston Island Brewery
Halloween Party 2017
Our forensics team solving mysteries with Sherlock
Sunday Funday seeing Joshua Bell
Texas Renaissance Festival is one of the largest in the US
We survived just barely.
Welcome Party on the Beach

Residents at Conferences List


Dr. Catherine Miller making friends at NAME 2017

Residents and Dr. Heather Stevenson at the 2017 TSP annual meeting

Residents and Attendings at the 2016 TSP award banquet

Cancer Biomarkers Conference II

2018 Cytopathology and Small Biopsy Update at Houston Methodist

Dr. Jianping Zhao at the 2018 TSP annual meeting

David UTMB Research Day

Dr. Brooke Blake meeting forensic pathologist Dr. Judy Melinek at NAME 2017

Drs. Maria Rivera Rolon and Mariana Moreno Prats at the 2017 TSP annual meeting

Drs. Catherine Miller and Brooke Blake at the 2017 NAME meeting

Drs. Adam Booth and Ranjana Nawgiri at CAP17

Drs. Adam Booth and Aijan Ukedeyva at the 2018 TSP annual meeting

Drs. Aaron Wyble and Adam Booth at the 2018 TSP annual meeting

Dr. Xiao-Meng Xu at the 2018 TSP annual meeting

Dr. Mariana Moreno Prats at the 2017 TSP annual meeting

Dr. Jacob Wooldridge at the 2018 TSP Annual Meeting

Dr. Jacob Wooldridge at the 2017 ASCP meeting

Dr. Adam Booth at the 2018 TSP Annual Meeting

Residents at USCAP 2018

Residents at the 2018 TSP Annual Meeting

Drs. Heather Stevenson and Adam Booth at USCAP 2018

Dr. Adam Booth representing the CAP at the 2018 AMA Annual Meeting

Dr. Adam Booth at the 2018 DDW Meeting

Dr. Adam Booth at the 2018 TSP Annual Meeting

Dr. Adam Booth at CAP17

Jing He, MD

I have a long research interest on cancer molecular biology and cancer pathogenesis. The focus of my research work have been studying the cancer biomarkers and cancer signaling pathways in carcinogenesis.
Xi’an Medical University P. R. China MD Medicine 1996
Xi’an Medical University P. R. China M Med Oncology 2000
The University of Texas Medical Branch Galveston, TX MS Biomedical Science 2006
The University of Texas Medical Branch Galveston, TX Residency Anatomic Pathology and Clinical Pathology 2015
Vanderbilt University Medical Center Nashville, TN Fellowship Surgical Pathology 2016
The University of Texas MD Anderson Cancer Center, Houston, TX Fellowship Cytopathology 2017
The University of Texas MD Anderson Cancer Center Cytopathology Staff Award 2017
United States and Canadian Academy of Pathology (USCAP) 2011- Present
College of American Pathologist (CAP) 2011- Present
American Society of Cytopathology 2016- Present
Articles
  1. He, J, Huo L, Ma J, Zhao J, Bassett R, Sun X, Ueno N, Lim B, Gong Y. Expression of Programmed Death Ligand 1 (PDL-1) in posttreatment primary inflammatory breast cancers and clinical implications. American Journal of Clinical Pathology. 2018; 149: 253-261
  2. He J, Gong Y. Epithelioid angiosarcoma: diagnostic pitfalls in fine-needle aspiration cytology. ASCP Case Reports. 2017 Dec 15th.
  3. Katsantonis N, Hunter J, O’Connell B, He, J, Lewis J, Wanna G. Temporal Bone Mucormycosis.Annals of Otology, Rhinology & Laryngology. 2016.
  4. Zhang Z, Finnerty CC, He J, Herndon DN. Smad Ubiquitination Regulatory Factor 2 Expression is Enhanced in Hypertrophic Scar Fibroblasts from Burned Children. Burns. 2012 Mar; 38(2):236-246. PMID: 21920670
  5. Yang L, He J, Huang S, Zhang X, Bian Y, He N, Zhang H, and Xie J. Activation of Hedgehog Signaling isnot a Frequent Event in Ovarian Cancers. Molecular Cancer. 2009 Nov 27; 8:112. PMID: 1994394119943941.
  6. He J, Sheng T, Stelter AA, Li C, Zhang X, Sinha M, Luxon BA, and Xie J. Suppressing Wnt Signaling by the Hedgehog Pathway through sFRP-1. The Journal of Biological Chemistry. 2006 Nov 24; 281(47):35598-35602. PMID: 17035233.17035233
  7. Huang S, He J (Co-first author), Zhang X, Bian Y, Yang L, Xie G, Zhang K, Tang W, Stelter AA, Wang Q, Zhang H, Xie J. Activation of the Hedgehog Pathway in Human Hepatocellular Carcinomas. Carcinogenesis. 2006 Jul; 27(7):1334-1340. PMID: 1650125316501253.
  8. Ma X, Sheng T, Zhang Y, Zhang X, He J, Huang X, Chen K, Sultz J, Adegboyega PA, Zhang H, Xie J. Hedgehog Signaling is Activated in Subsets of Esophageal Cancers. International Journal of Cancer, 2006 Jan 1; 118(1):139-148. PMID: 1600373716003737.
  9. Yang DZ, He J, Zhang JC, Wang ZR. Expression of Angiostatin cDNA in Human Gallbladder Carcinoma Cell Line GBC-SD and its Effect on Endothelial Proliferation and Growth. World Journal of Gastroenterology, 2006 May 7; 12(17):2762-2766. PMID: 16718765.
  10. Yang DZ, He J, Zhang JC, Wang ZR. Angiostatin Inhibits Pancreatic Cancer Cell Proliferation and Growth in Nude Mice. World Journal of Gastroenterology, 2005 Aug 28; 11(32):4992-4996. PMID: 16124051.
  11. Yang DZ, He J, et al. Expression of MMP-9 in Cholangiocarcinoma and their Significance, Journal of Practice Oncology, 2004; 18(2): 95.
  12. Yang DZ, He J, et al. Expression of E-cadherin in Carcinoma of Gallbladder and its Relationship with the Invasion and Metastasis. Shaanxi Medical Journal, 2004; 33(2):111.
  13. Xiao J, Han M, He J, et al. Expression of Thymidine Phosphorylase and Lung Resistance Protein in Human Colorectal Carcinoma and its Clinical Significance, West China Medical Journal, 2004; 19(1): 24.
  14. Qin T, Gao Y, He J, et al. Combined Administration with Huachansu and Chemotherapy for Gastrointestinal Cancer, Shaanxi Traditional Medicine, 2002; 23(1): 35.
  15. Qin T, Gao Y, Xiao J, He J, et al. Combination Chemotherapy with IAP, MVP in Non-small-cell Lung Cancer, Journal of Xi’an Medical University, 2002; 23(1): 82.
  16. Yang DZ, He J, et al. The FAS Signaling Pathway and Cancer, Journal of Medical Laboratory Science, 2000; 15(4): 63.
  17. Yang DZ, He J, et al. Expression of Apoptosis Related Protein in Cholangio- carcinoma and its Significance. Shaanxi Medical Journal, 2000; 29(12): 720.
  18. Yang DZ, He J, et al. The Expression of BAX Protein and FAS Antigen in Cholangiocarcinoma and its Significance. Shaanxi Oncology Medicine, 1999; 7(4): 208.
Book Chapters
  1. He J. “Calcifying Fibrous Pseudotumor of Pleura”. In J.H. van Krieken (Ed.), Encyclopedia of Pathology. 2018; Berlin, Heidelberg: Springer.
  2. He J, Nan K, “Solid Tumors in Children”. In: Kejun Nan, ed. Modern Tumor Therapeutics, Beijing: World Publishing Corporation, 2003; Chapter 46: P657-675.

Christopher J. Zahner, MD

Dr. Zahner's basic research has focused on medical devices and resulted in hardware development, grants, and patents in the fields of balance, acoustics, sample processing, and microbial growth, along with prototype hardware in sample tracking and hand hygiene. His clinical research is focused on diagnostic error using the diagnostic management team and mobile app development.
University of Florida MS Mechanical Engineering 2005
Texas Tech Health Sciences Center MD Medicine 2015
University of Texas Medical Branch CP Pathology 2018
United Space Alliance – Employee of the Year 2008

Usama A. Yassi, MD

My interest is in finding the significance of increased plasma cells in cases of microscopic colitis.

Almustansiriyah College of Medicine – Baghdad, Iraq

MBChB

Medicine and Surgery

2004

University of South Dakota – Sioux Falls, South Dakota

 

Anatomic and Clinical Pathology

2017

University of Texas Medical Branch – Galveston, Texas

 

Surgical Pathology

2018

Gbo Yuoh award in recognition of commitment to teaching pathology residents. 2017
College of American Pathologists 2013

United States and Canadian Academy of Pathology 2017

Tjarks, B.J., Yassi, U., Jassim, A.D: A rare case of primary cutaneous osteosarcoma. Abstracts and Case Studies from the College of American Pathologists 2015 Annual Meeting (CAP '15). Archives of Pathology & Laboratory Medicine. 139(10):e82, 2015

Usama Yassi, MD; Amy Kerkvliet, MD; RJ Summerer, DO; Ali Jassim, MD, PhD. Eccrine Spiradenoma, lymphangiectatic variant. Platform presentation, 18th joint ISDP meeting, San Francisco, CA, 2015. South Dakota medical journal. Vol. 69 Issue 8, p359-361. 3p.

Vasantha Gali, MD; Usama Yassi, MD; Sarah Sarbacker,MD; Ali Jassim, MD, PhD. Cutaneous glomeruloid hemangioma: a report on two cases and a review of literature. South Dakota medical journal. Vol. 70 Issue 6, p250-251.

Vasantha Gali, MD; Usama Yassi, MD; Ali Jassim, MD, PhD. Desmoplastic dermatofibrosarcoma protuberans. ASDP case of the month, November 2016.

Michael Laposata, MD, PhD

  • I have had a long interest on laboratory test utilization, particularly as it relates to coagulation studies, my area of expertise. A principal focus of the work has been the identification of diagnostic errors and mechanisms to prevent them.
  • I have been a fatty acid biochemist for 35 years. My early research career included the study of biological mechanisms associated with the conversion of fatty acids into eicosanoids. The focus was to identify the pool of eicosanoid precursor fatty acids in the cell and how they became available for eicosanoid production. I later investigated the covalent association of fatty acids to proteins by thioester linkages with Dr. Laszio Muszek, who was later elected to the Hungarian National Academy of Sciences. My laboratory also included fatty acid related studies involved an esterification product of ethanol and fatty acids, fatty acid ethyl esters (FAEE), and fatty acid abnormalities found in patients with cystic fibrosis.
  • I have continuously written articles on topics related to diagnosis of coagulation disorders and optimization of clinical laboratory operations. This led to the production of several books, including a major textbook entitled Laboratory Medicine: The Diagnosis of Disease in the Clinical Laboratory, published by McGraw-Hill in the prestigious Lange series of medical textbooks. The third edition has been named Laposata’s Laboratory Medicine.
BA Bucknell University Lewisburg, PA 1974
MD Johns Hopkins University School of Medicine Baltimore, MD 1981
PhD Johns Hopkins University School of Medicine Baltimore, MD 1982
Residency Division of Laboratory Medicine,
Departments of Pathology and Medicine
Washington University School of Medicine
St. Louis, MO
1985

Certification: Diplomate, American Board of Pathology

1988-89 Christian R. and Mary F. Lindback Distinguished Teaching Award, University of Pennsylvania School of Medicine (2 medical school faculty selected annually)
1989 University of Pennsylvania School of Medicine Commencement Speaker (one faculty member selected by vote of graduating class of 1989)
1998 A. Clifford Barger Excellence in Mentoring Award, Harvard Medical School (4 awardees selected among hundreds of nominated faculty members)
1999, 2000, 2005 Award for Most Distinguished Teacher in the Preclinical Years, Harvard Medical School (1 awardee by the vote of the graduating class)
2005 Award from the Institute for Quality in Laboratory Medicine (IQLM) of the Centers for Disease Control and Prevention (CDC) for “Improved Clinical Integration” of Laboratory Medicine Services. One of 10 major awards in 2005 by the IQLM.
2006 - 2007 Boston Magazine’s Best of Boston Doctors (Top 100-200 local physicians among  5000 licensed doctors)
2014-2016 National Academy of Medicine Committee on Diagnostic Error in Medicine
2015 The Pathologists’ 2015 Pathologist Power List, #3 globally, #1 in US (The Pathologists Issue 13, 2015)

Sean G. Yates, MD

My research efforts are aimed at improving patient safety and clinical outcomes, while also reducing the need for allogeneic blood components and provide insight and helping foster development of diagnostic and prognostic testing to further the advancement of patient blood management and support hemorrhagic and thrombotic diseases.
BS Texas Tech University, Lubbock, TX 2005
MD University of Texas Health Sciences Center at Houston, Houston, TX 2011
Residency University of Texas Southwestern, Dallas, TX 2014
Fellowship University of Texas Southwestern, Dallas, TX 2015
Travel Award South Central Association of Blood Banks; Las Vegas, NV 2015
Travel Award Thrombosis and Hemostasis Summit of North America; Chicago, IL 2014
Teaching Award, Medical Student Curriculum University of Texas Southwestern Medical Center, Dallas, TX 2014
Society for the Advancement of Blood Management 2018 – Present
AABB 2014 – Present
International Society on Thrombosis and Haemostasis 2014 – Present

Reddy M, Tawfik B, Gavva C, Yates S, De Simone N, Hofmann SL, Rambally S, Sarode R. Ischemic stroke in a patient with moderate to severe inherited factor VII deficiency. Transfus Apher Sci. 2016 Dec;55(3):364-367. doi: 10.1016/j.transci.2016.10.002. Epub 2016 Oct 17. PubMed PMID: 27776919.

Related citations

Yates SG, Smith S, Tharpe W, Shen YM, Sarode R. Can an anti-Xa assay for low-molecular-weight heparin be used to assess the presence of rivaroxaban? Transfus Apher Sci. 2016 Oct;55(2):212-215. doi: 10.1016/j.transci.2016.06.005. Epub 2016 Jun 27. PubMed PMID: 27377884.

Cited in PMCRelated citations

Gavva C, Yates SG, Rambally S, Sarode R. Transfusion management of factor V deficiency: three case reports and review of the literature. Transfusion. 2016 Jul;56(7):1745-9. doi: 10.1111/trf.13623. Epub 2016 Apr 28. PubMed PMID: 27125565.

Cited in PMCRelated citations

Shen YM, Tsai J, Taiwo E, Gavva C, Yates SG, Patel V, Frenkel E, Sarode R. Analysis of Thrombophilia Test Ordering Practices at an Academic Center: A Proposal for Appropriate Testing to Reduce Harm and Cost. PLoS One. 2016 May 13;11(5):e0155326. doi: 10.1371/journal.pone.0155326. eCollection 2016. PubMed PMID: 27176603; PubMed Central PMCID: PMC4866738.

Free full textCited in PMCRelated citations

Joseph R, Burner J, Yates S, Strickland A, Tharpe W, Sarode R. Thromboembolic outcomes after use of a four-factor prothrombin complex concentrate for vitamin K antagonist reversal in a real-world setting. Transfusion. 2016 Apr;56(4):799-807. doi: 10.1111/trf.13406. Epub 2015 Nov 20. PubMed PMID: 26589481.

Cited in PMCRelated citations

Yates SG, Gavva C, Agrawal D, Sarode R. How do we transfuse blood components in cirrhotic patients undergoing gastrointestinal procedures? Transfusion. 2016 Apr;56(4):791-8. doi: 10.1111/trf.13495. Epub 2016 Feb 15. PubMed PMID: 26876945.

Related citations

 Yates S, Sarode R. Reversal of anticoagulant effects in patients with intracerebral hemorrhage. Curr Neurol Neurosci Rep. 2015 Jan;15(1):504. doi: 10.1007/s11910-014-0504-2. Review. PubMed PMID: 25407132.

Cited in PMCRelated citations

 Yates S, Matevosyan K, Rutherford C, Shen YM, Sarode R. Bortezomib for chronic relapsing thrombotic thrombocytopenic purpura: a case report. Transfusion. 2014 Aug;54(8):2064-7. doi: 10.1111/trf.12614. Epub 2014 Mar 24. PubMed PMID: 24655327.

Cited in PMC Related citations

 Yates SG, Sarode R. Is platelet transfusion necessary in cirrhotic patients with splenomegaly? Liver Int. 2014 Jan;34(1):164-5. doi: 10.1111/liv.12332. Epub 2013 Oct 16. PubMed PMID: 24102873.

Related citations

 Yates S, Sarode R. Novel thrombin and factor Xa inhibitors: challenges to reversal of their anticoagulation effects. Curr Opin Hematol. 2013 Nov;20(6):552-7. doi: 10.1097/MOH.0b013e328365a164. Review. PubMed PMID: 24104417

Vasilakis Current Lab Members

Curriculum Vitae

Present Position and Address

Doctoral Candidate
University of Texas Medical Branch at Galveston
Institute for Translational Sciences
Human Pathophysiology and Translational Medicine
301 University Blvd.
Galveston TX, 77555-1019
srazar@utmb.edu

Education

08/2014-Present Graduate Student
Human Pathophysiology and Translational Medicine
Institute for Translational Sciences
University of Texas Medical Branch, Galveston, TX
08/2011-06/2013 Master’s of Science in Biomedical Sciences
University of California Riverside, Riverside, CA
08/2007-06/2011 Bachelor’s of Science in Microbiology (Major) and Psychology (Minor)
University of California San Diego, San Diego, CA

Professional and Teaching Experience

01/2016-Present Graduate Student
Institute for Translational Sciences
University of Texas Medical Branch, Galveston TX
Mentor: Dr. Scott C. Weaver
Project: "Bloodmeal determinants of arbovirus infection of Aedes (Stegomyia) spp. mosquitoes"
11/2012-3/2013 Graduate Student
Department of Biomedical Sciences
University of California Riverside, Riverside, CA
Mentor: Dr. Christian Lytle, PhD
Project: “Colonic mucus regulation in homeostasis and disease”
03/2012-10/2012 Graduate Student
Department of Biomedical Sciences
University of California Riverside, Riverside, CA
Mentor: Dr. David Lo, MD, PhD
Project: “Role of tight junction proteins in non-canonical large particle endocytosis”
10/2009-08/2011 Undergraduate Researcher
Department of Pathology
University of California San Diego, San Diego, CA
Mentor: Dr. Dwayne Stupack, PhD
Project: “Role of Src family kinases and Focal Adhesion kinase in neuroblastoma resistance to anoikis in 3-dimensional cell culture models”
Training/Supervision of Undergraduate, Graduate, and Medical Students
04/2018-04/2018 Hands-On Trainer for Viral Isolation and Quantification; Vector Borne Disease Course, Western Gulf Center of Excellence for Vector Borne Disease
01/2018-02/2018 Barbara Chaves, Graduate Student, Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil
10/2017-12/2018 Ana Carolina Terzian, PhD. Faculdade de MedicFaculdade de Medicina de São José do Rio Preto | FAMERP
6/2016-8/2016 Scott Segura, Undergraduate: University of Texas Dallas, Summer
Undergraduate Research Program (SURP)

Memberships in Scientific Societies

04/2016-Present Member: American Society for Tropical Medicine and Hygiene
04/2016-Present Member: American Society of Microbiology
03/2017-Present Member: American Society of Virology

Academic and Professional Honors
James W. McLaughlin Annual Colloquium: Poster Session Travel Award, March 31, 2017
McLaughlin Predoctoral Fellow: September 1, 2017 to present

Bibliography

Abstracts

  1. Azar SR, Rossi SL, Haller SL, Yun R, Leal G, Zhou J, Huang J, Hanley KA, Weaver SC, Vasilakis NV. Zika virus demonstrates minimal pathology and mosquito infectivity in viremic cynomolgus macaques. Poster at the PanAmerican Dengue Research Network Meeting. Galveston, TX, April 9-12, 2018
  2. Azar SR, Roundy CM, Rossi SL, Huang JH, Yun R, Hanley KA, Vasilakis N, Weaver SC. Vector competence analysis of Aedes (Stegomyia) spp. mosquitoes from the Americas for Zika Virus. Poster at International Union of Microbiological Societies 2017.  Singapore, Singapore, July 17-21, 2017
  3. Azar SR, Roundy CM, Rossi SL, Huang JH, Yun R, Hanley KA, Vasilakis N, Weaver SC. Vector competence of American Aedes albopictus (Skuse)  populations for various strains of Zika virus. Poster at Sao Paulo School of Advanced Sciences: Arbovirology, Sao Jose do Rio Preto, Brazil, May 29, 2017
  4. Azar SR, Roundy CM, Rossi SL, Huang JH, Yun R, Hanley KA, Vasilakis N, Weaver SC. Vector competence of American Aedes albopictus (Skuse)  populations for various strains of Zika virus. Poster at Annual McLaughlin Symposium, Galveston, TX, March 31, 2017.
  5. Azar SR, Roundy CM, Rossi SL, Huang JH, Yun R, Hanley KA, Vasilakis N, Weaver SC. Vector competence analysis of Aedes (Stegomyia) spp. mosquitoes from the Americas for Zika Virus. Poster at Gordon Research Conference: Tropical Infectious Diseases, Galveston, TX, March 13-14, 2017
  6. Azar SR,  Tesh RB,  Muruato AE, Hanley KA, Auguste AJ, Langsjoen RM, Paessler S, Vasilakis N, Weaver SC, Rossi SL (2016). Development and Characterization of a Small Animal Model of Zika Virus infection. Poster at Annual McLaughlin Symposium, Galveston, TX, April 2016.

Publications in Peer Reviewed Journals:

  1. Vanchiere JA, Ruiz JC, Brady AG, Kuehl TJ, Williams LE, Bazar WB, Wilkerson GK, Nehete PN, McClure GB, Rogers DL, Rossi SL, Azar SR, Roundy CM, Weaver SC, Vasilakis N, Simmons JH, Abee CR, 2017. Experimental Zika Virus Infection of Neotropical Primates. Am J Trop Med Hyg. (Published Online Ahead of Print) doi: 10.4269/ajtmh.17-0322
  2. Roundy CM, Azar SR, Brault AC, Ebel GD, Failloux A, Fernandez-Salas I, Kitron U, Kramer LD, Lourenço-de-Oliveira R, Osorio JE, Paploski ID, Vazquez-Prokopec GM, Ribeiro GS, Ritchie SA, Tauro LB, Vasilakis, Weaver SC, 2017. Lack of evidence for Zika virus transmission by Culex mosquitoes. Emerg Microbes Infect 6: e90.doi: 10.1038/emi.2017.85.
  3. Azar SR, Roundy CM, Rossi SL, Huang JH, Leal G, Yun R, Fernandez-Salas I, Vitek CJ, Paploski IAD, Stark PM, Vela J, Debboun M, Nava MR, Kitron U, Ribeiro GS, Hanley KA, Vasilakis N, Weaver SC. Differential vector competency of Aedes albopictus populations from the Americas for Zika virus. Am J Trop Med Hyg 97: 330-339. doi: 10.4269/ajtmh.16-0969
  4. Zhao Z, Yang M, Azar SR, Soong L, Weaver SC, Sun J, Chen Y, Rossi SL, Cai J, 2017. Viral Retinopathy in Experimental Models of Zika Infection. Invest Ophthalmol Vis Sci 58: 4075–4085. doi:  10.1167/iovs.17-22016
  5. Roundy CM, Azar SR, Rossi SL, Huang JH, Leal G, Yun R, Fernandez-Salas I, Vitek CJ, Paploski IAD, Kitron U, Ribeiro GS, Hanley KA, Weaver SC, Vasilakis N, 2017. Variation in Aedes aegypti competence for Zika virus transmission as a function of viral strain, blood meal type, and mosquito geographic origin. Emerg Infect Dis 23: 625-632. doi: 10.3201/eid2304.16148
  6. McGrath EL, Rossi SL, Gao J, Widen SG, Grant AC, Dunn TJ, Azar SR, Roundy CM, Xiong Y, Prusak DJ, Loucas BD, Wood TG, Yu Y, Fernandez-Salas I, Weaver SC, Vasilakis N, Wu P, 2017. Differential Responses of Human Fetal Brain Neural Stem Cells to Zika Virus Infection. Stem Cell Rep. doi:10.1016/j.stemcr.2017.01.008
  7. Hart CE, Roundy CM, Azar SR, Huang JH, Yun R, Reynolds E, Leal G, Nava MR, Vela J, Stark PM, Debboun M, Rossi SL, Vasilakis N, Thangamani S, Weaver SC, 2017. Zika Virus Vector Competency of Mosquitoes, Gulf Coast, United States. Emerg Infect Dis 23: 559–560.
  8. Vinhaes ES, Santos LA, Dias L, Andrade NA, Bezerra VH, de Carvalho AT, de Moraes L, Henriques DF, Azar SR, Vasilakis N, Ko AI, Andrade BB, Sigueira IC, Khouri R, Boaventura VS, 2016. Transient Hearing Loss in Adults Associated with Zika Virus Infection. Clin Infect Dis: doi:10.1093/cid/ciw770
  9. Guerbois M, Fernandez-Salas I, Azar SR, Danis-Lozano R, Alpuche-Aranda CM, Leal G, Garcia-Malo IR, Diaz-Gonzalez EE, Casas-Martinez M, Rossi SL, Del Río-Galván SL, Sanchez-Casas RM, Roundy CM, Wood TG, Widen SG, Vasilakis N, Weaver SC, 2016. Outbreak of Zika virus infection, Chiapas State, Mexico, 2015, and first confirmed transmission by Aedes aegypti mosquitoes in the Americas. J Infect Dis: Pii: jiw302
  10. Smalley C, Bechelli J, Brouwer D, Saito TB, Azar SR, Ismail N, Walker DH, Fang R, 2016. Rickettsia australis Activates ASC-Dependent Inflammasome in Macrophages Only Transiently Involving NLRP3. PLoS One 11:e0157231
  11. Shan C, Xie X, Muruato AE, Rossi SL, Roundy CM, Azar SR, Yang Y, Tesh RB, Bourne N, Barrett AD, Vasilakis N, Weaver SC, Shi PY, 2016. An infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors. Cell Host Microbe 19:891-900
  12. Rossi SL, Tesh RB, Azar SR, Muruato AE, Hanley KA, Auguste AJ, Langsjoen RM, Paessler S, Vasilakis N, Weaver SC, 2016. Characterization of a Novel Murine Model to Study Zika Virus. Am J Trop Med Hyg 94:1362-9
  13. Ponsnusamy D, Kozlova EV, Sha J, Erova TE, Azar SR, Fitts EC, Kirtley ML, Tiner BL, Andersson JA, Grim CJ, Isom RP, Hasan NA, Colwell RR, Chopra AK, 2016. Cross-talk among flesh-eating Aeromonas hydrophila strains in mixed infection leading to necrotizing fasciitis. Proc Natl Acad Sci USA 113:722-7

Book Chapters

  1. Roundy CM, Azar SR, Rossi SL, Weaver SC, Vasilakis N, 2017. Insect-Specific Viruses: A Historical Overview and Recent Developments. Adv Virus Res 98: 119-146

Invited Presentations

  1. Azar SR. Vector competence analysis of Aedes (Stegomyia) spp. mosquitoes from the Americas for Zika Virus. Invited Oral presentation: International Collaboration in Infectious Disease Research: Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil, March 19, 2018
  2. Azar SR.The A129 mouse model of Zika Virus Infection: Initial characterization and subsequent applications. Invited oral presentation: AALAS National Meeting, Session: “Sex, Blood & Babies: Animal Models of Zika Virus Research”, Austin, TX, October 17, 2017
  3. Azar SR. Vector competence analysis of Aedes (Stegomyia) spp. mosquitoes from the Americas for Zika Virus. Invited Oral presentation: Gordon Research Conference: Tropical Infectious Diseases, Galveston, TX, March 14, 2017
Curriculum Vitae

Current position

Research Fellow
Department of Pathology
University of Texas Medical Branch
301 University Boulevard
Galveston TX-77555
adhendy@utmb.edu

Education

11/2013-02/2018 PhD
Biomedical Sciences
Institute of Tropical Medicine/University of Antwerp, Antwerp, Belgium
09/2011-09/2012 MSc
Biology and Control of Disease Vectors
London School of Hygiene & Tropical Medicine, London, UK
09/2001-06/2004 BSc Biological Sciences and Parasitology
King’s College London, London, UK

Professional Experience

02/2018 - Present Research Fellow
Department of Pathology
University of Texas Medical Branch, Galveston, TX
Supervisor: Prof. Nikos Vasilakis
Project: Transmission and emergence dynamics of emerging zoonotic arboviruses.
11/2013 - 1/2018 Predoctoral Assistant
Department of Biomedical Sciences
Institute of Tropical Medicine, Antwerp, Belgium
Supervisors: Prof. Jean-Claude Dujardin, Prof. Dirk Berkvens
Project: Blackfly ecology and Onchocerca volvulus transmission in three formerly hyperendemic foci in Uganda, Tanzania and Cameroon.
01/2013 - 10/2013 Education and Research Assistant
Department of Life Sciences
Natural History Museum, London, UK
Supervisors: Dr. John Tweddle, Dr. Erica McAlister
Project I: Delivering educational programmes in insect ecology and botany on behalf of the Natural History Museum to Cothill Education Trust.
Project II: Developing a pictorial identification key for nine species of Aedes (Albuginosus) mosquitoes.
02/2010 - 09/2011 Research Assistant/Volunteer
Department of Life Sciences
Natural History Museum, London, UK
Supervisors: Dr Mark Spencer, Dr. Erica McAlister
Project I: Modelling the impact of climate-related events on plant and animal phenology using data held in museum collections.
Project II: Identification of spirit-preserved insects collected in French Guiana.

Academic and Professional Awards

FWO Travel Grant: Awarded funding for a one-month research stay at Clemson University, SC (2015).
Flemish Government SOFI Grant: Awarded €665,038 (as co-applicant) for the project "An interdisciplinary study contributing to the identification of the cause of nodding syndrome in four countries" (2014).
John Spedan Lewis Foundation: Awarded £5,000 to study the morphology, phylogenetics and bionomics of Aedes (Albuginosus) mosquitoes (2013).
Mansfield Aders Scholarship: Awarded tuition fees to study a master’s degree at the London School of Hygiene & Tropical Medicine (2011).

Conferences and Presentations

10th European Congress on Tropical Medicine and International Health (ECTMIH), 2017. Antwerp, Belgium. "The blackfly vectors and transmission of Onchocerca volvulus in Mahenge, south eastern Tanzania." Oral presentation.

10th European Congress on Tropical Medicine and International Health (ECTMIH), 2017. Antwerp, Belgium. "Esperanza Window Traps for the collection of anthropophilic blackflies (Diptera: Simuliidae) in Uganda and Tanzania." Poster presentation.

1st International Workshop on Onchocerciasis Associated Epilepsy (OAE), 2017. Antwerp, Belgium. "Blackfly ecology and O. volvulus transmission in Uganda, Tanzania and Cameroon." Oral presentation.

1st International Workshop on Onchocerciasis Associated Epilepsy (OAE), 2017. Antwerp, Belgium. "The blackfly vectors and transmission of Onchocerca volvulus in Mahenge, south eastern Tanzania." Poster presentation.

2nd International Conference on Nodding Syndrome, 2015. Gulu, Uganda. "Blackflies (Diptera: Simuliidae) and Onchocerca infection in Nodding Syndrome-affected districts of northern Uganda." Oral Presentation.

13th Annual North American Black Fly Association (NABFA) Meeting, 2015, Athens, Georgia, USA. "Investigating a relationship between blackflies (Diptera: Simuliidae), onchocerciasis and Nodding Syndrome: An entomological perspective." Oral Presentation.

Publications

Hendy, A., Krüger, A., Pfarr, K., De Witte, J., Kibweja, A., Mwingira, U., Dujardin, J.C., Post, R., Colebunders, R., O’Neill, S. & Kalinga, A., 2018. The blackfly vectors and transmission of Onchocerca volvulus in Mahenge, south eastern Tanzania. Acta Tropica, 181, pp.50-59. https://doi.org/10.1016/j.actatropica.2018.01.009  
Hendy, A., Sluydts, V., Tushar, T., De Witte, J., Odonga, P., Loum, D., Nyaraga, M., Lakwo, T., Dujardin, J.C., Post R.J., Kalinga, A. & Echodu, R., 2017. Esperanza Window Traps for the collection of anthropophilic blackflies (Diptera: Simuliidae) in Uganda and Tanzania. PLOS Neglected Tropical Diseases, 11(6): e0005688. https://doi.org/10.1371/journal.pntd.0005688
Colebunders, R., Hendy, A. & van Oijen, M., 2014. Nodding syndrome in onchocerciasis endemic areas. Trends in Parasitology. https://doi.org/10.1016/j.pt.2016.05.013 
Orsborne, J., DeRaedt Banks, S., Hendy, A., Gezan, S.A., Kaur, H., Wilder-Smith, A., Lindsay, S.W. & Logan, J.G., 2016. Personal protection of permethrin-treated clothing against Aedes aegypti, the vector of dengue and Zika virus, in the laboratory. PLOS ONE, 11(5): e0152805. https://doi.org/10.1371/journal.pone.0152805  
Colebunders, R., Hendy, A., Mokili, J., Wamala, J., Kaducu, J., Kur, L., Tepage, F., Mandro, M., Mucinya, G., Mambandu, G., Komba, M., Lumaliza, J., van Oijen, M. & Laudisoit, A., 2016. Nodding syndrome and epilepsy in onchocerciasis endemic regions: comparing preliminary observations from South Sudan and the Democratic Republic of the Congo with data from Uganda. BMC Research Notes, 9:182. https://doi.org/10.1186/s13104-016-1993-7
Deblauwe, I., Demeulemeester, J., De Witte, J., Hendy, A., Sohier, C. & Madder, M., 2015. Increased detection of Aedes albopictus in Belgium: no overwintering yet, but an intervention strategy is still lacking. Parasitology Research, 114, pp.3469–3477. https://doi.org/10.1007/s00436-015-4575-z
Colebunders, R., Post, R., O’Neill, S., Haesaert, G., Opar, B., Lakwo, T., Laudisoit, A. & Hendy, A., 2015. Nodding syndrome since 2012: recent progress, challenges and recommendations for future research. Tropical Medicine & International Health, 20(2), pp.194-200. https://doi.org/10.1111/tmi.12421
Colebunders, R., Hendy, A., Nanyunja, M., Wamala, J.F. & van Oijen, M., 2014. Nodding syndrome—a new hypothesis and new direction for research. International Journal of Infectious Diseases, 27, pp.74-77. http://dx.doi.org/10.1016/j.ijid.2014.08.001
Demeulemeester, J., Deblauwe, I., De Witte, J., Jansen, F., Hendy, A. & Madder, M., 2014. First interception of Aedes (Stegomyia) albopictus in Lucky bamboo shipments in Belgium. Journal of the European Mosquito Control Association, 32, pp.14-16.

Curriculum Vitae

Appointment: Research Associate II
Professional Education

2005 M.S. Latrobe University, Australia Health Administration
1993 B.S. Capital Medical University, China Senior Nursing Profession
Research Interests Basic research on the genetics, ecology, evolution and pathogenesis of arthropodborne
viruses (arboviruses), virusmosquito interactions, and vaccine development.

Professional Experience

12.17.2015- Present Research Associate II, Department of Pathology,
University of Texas Medical Branch, Galveston, TX
12.15.2014 -12.16.2016 Research Fellow, Department of Pediatrics,
University of Texas Medical Branch, Galveston, TX
10.24.2014 – 12.14.2014 Visiting Scientist, Department of Pathology,
University of Texas Medical Branch, Galveston, TX
08.2013 – 10.2014 Research Assistant, Department of Public Health,
Harbin Medical University of Heilongjiang, China

Selected Publications

Zhou Jiehua, Liu S, Fu Y, Chen Y, Silver AJ, Hill SM, Lee I, Lee YS, and Bao X.
"Identification of two novel functional tRNA-derived fragments induced in response toRSV infection", J Gen Virol. 2017 Jul

Chen Y, Deng X, Deng J, Zhou Jiehua, Ren Y, Prusak,DJ, Wood TG, and Bao X. "Functional Motif Responsible for Human Metapneumovirus M2-2-mediated InnateImmune Evasion". Virology. 2016, accepted

Deng J, Ptashkin RN, Chen Y, Cheng Z, Liu G, Phan T, Deng X, Zhou J, Lee I, Lee YS, Bao X. "Respiratory Syncytial Virus Utilizes a tRNA Fragment to Suppress Antiviral Responses Through a Novel Targeting Mechanism." Mol Ther. 2015 Oct;23(10):1622-9

Jack Alperin, MD

The clinical investigation of problems related to benign diseases of the blood (e.g. hemostasis & thrombosis, hemoglobinopathies, anemia, thrombocytopenia).
MD College of Medicine, University of Tennessee Medicine 1957
Internship

Michael Reese Hospital, Chicago, Illinois

Internal Medicine Residency, and Hematology Fellowship 1963
Fellowship University of Texas Medical Branch, Galveston, Texas Senior Hematology Research Fellow 1965
2001 Inaugural Scholar in the John P. McGovern Academy of Oslerian Medicine, University of Texas Medical Branch, Galveston, Texas
2005 Laureate Award, Texas Chapter, American College of Physicians
  • American Society of Hematology
  • Texas and American Medical Associations
  • Galveston County Medical Society
  • American Osler Society
  • American College of Physicians
  • International Society of Thrombosis and Haemostasis
  • International Society of Haemotology
  • American Association of Blood Banks

Natalie Williams-Bouyer, PhD

Antimicrobial resistance trends. Antimicrobial resistance trends have been a long standing interest of mine. I am particularly interested in the origins of microorganisms that acquire multiple antibiotic resistance. Individuals infected with drug-resistant organisms are more likely to have longer hospital stays and require treatment with second- or third-generation drugs that may be more toxic, and/or more expensive. Therefore, the intent of my research is to utilize molecular techniques to study the epidemiology of multidrug-resistant organisms (MDRO), as a means of prevention and control of infections caused by these microbes. Ideally, these methods will lead to an improved efficacy in the characterization of antimicrobial resistant organisms isolated in the clinical microbiology laboratory.
BS University of Southwest Louisiana,
Lafayette, LA
Microbiology 1989
PhD Meharry Medical College, Nashville, TN Microbiology 1997
Post-Doctoral Fellow University of Texas Medical Branch, Galveston, TX Clin/Public Health Microbiology 1999
1998 American Society for Microbiology Student Travel Award
1997 Who's Who Among Students in American Universities and Colleges
1995-1997 National Science Foundation Research Center of Excellence of Meharry Medical College (MRCE) Fellowship
1995 Who's Who Among Students in American Universities and Colleges
1994 American Society for Microbiology Supplemental Fellowship
1993 American Society for Microbiology Student Travel Award
1992-1995 Patricia Roberts Harris Fellowship
1990-1992 Minority Biomedical Research Support (MBRS) Program Fellowship

Appointments
2007-Present Assistant Director Division of Clinical Microbiology, Department of Pathology, University of Texas Medical Branch, Galveston, Texas
2005-Present Assistant Professor Department of Pathology, University of Texas Medical Branch, Galveston, Texas
2005-2009 Director Clinical Laboratory Services, Shriners Hospitals for Children, Galveston, Texas
2004-2005 Assistant Bureau Chief Clinical Services Section, Bureau of Laboratory Services, Houston Department of Health and Human Services, Houston, Texas
2001-2004 Research Associate/
Laboratory Manager
Houston Tuberculosis Initiative, Department of Pathology, Baylor College of Medicine, Houston, Texas
1999-2001 Clinical Instructor Division of Clinical Microbiology, Department of Pathology, University of Texas Medical Branch, Galveston, Texas
1999-1999 Acting Director Parasitology , Division of Clinical Microbiology, Department of Pathology, University of Texas Medical Branch, Galveston, Texas
1999-1999 Course Laboratory Assistant Pathobiology and Host Defense Laboratory, University of Texas Medical Branch, Galveston, Texas
1998-1999 Microbiology Lab Contact CDC National Nosocomial Infections Surveillance System- Intensive-Care Antimicrobial Resistance Epidemiology (ICARE), University of Texas Medical Branch, Galveston, Texas
1997-1998 Study Coordinator Swab Equivalency Study for the Collection of Female Endocervical Specimens (Gen-Probe Inc.), University of Texas Medical Branch, Galveston, Texas
1992-1993 Medical Microbiology Laboratory Instructor Department of Microbiology, Meharry Medical College, Nashville, Tennessee
1990-1997 Graduate Research Assistant Department of Microbiology, Meharry Medical College, Nashville, Tennessee
2008-Present Society for Healthcare Epidemiology of America
2006-2008 American Burn Association
2006-2008 International Society for Burn Injuries
2005-Present Clinical Laboratory Management Association
2005-Present Association of Public Health Laboratories
1995-1997 American Society for Clinical Laboratory Science
1990-1997 Sigma Delta Epsilon/Graduate Women in Science
1988-Present American Society for Microbiology
  1. Williams-Bouyer NM and McGinnis Hill E. Involvement of host cell tyrosine phosphorylation in the invasion of HEp-2 cells by Bartonella bacilliformis. FEMS Microbiology Letters 171:191-201, 1999.
  2. Williams-Bouyer N, Reisner BS, Woodmansee CE, Falk PS and Mayhall CG. Comparison of the Vitek GPS-TB card to disk diffusion testing for predicting the susceptibility of enterococci to vancomycin. Archives of Pathology and Laboratory Medicine 123:622-625, 1999.
  3. Williams-Bouyer N, Hernandez A and Reisner BS. Predicting the susceptibility of Streptococcus pneumoniae to ceftriaxone and cefotaxime by cefuroxime and ceftizoxime disk diffusion testing. Journal of Clinical Microbiology 37:3707-3710, 1999.
  4. Williams-Bouyer N, Reisner BS and Woods GL. Comparison of Gen-Probe AccuProbe group B streptococcus culture identification test with conventional culture for the detection of group B streptococci in broth cultures of vaginal-anorectal specimens from pregnant women. Diagnostic Microbiology and Infectious Disease 36:159-162, 2000.
  5. Williams-Bouyer N, Yorke R, Lee HI and Woods GL. Comparison of the MGIT 960 and ESP Culture System II for growth and detection of mycobacteria. Journal of Clinical Microbiology. 38: 4167-4170, 2000.
  6. Woods GL, Bergmann JS, and Williams-Bouyer N. Clinical evaluation of the Gen-Probe Amplified Mycobacterium Tuberculosis Direct Test for rapid detection of M. tuberculosis in select nonrespiratory specimens. Journal of Clinical Microbiology. 39: 747-749, 2001.
  7. El Sahly HM, Septimus E, Soini H, Septimus J, Wallace RJ, Xi P, Williams-Bouyer N, Musser JM, and Graviss EA. Mycobacterium simiae Pseudo-Outbreak Resulting from Contaminated Hospital Water Supply in Houston, Texas. Clinical Infectious Diseases. Clinical Infectious Diseases. 35: 802-807, 2002.
  8. Woods GL, Williams-Bouyer N, Wallace RJ, Brown-Elliott BA, Witebsky FG, Conville,PS, Plaunt M, Hall G, Aralar P and Inderlied C. Multisite Reproducibility of Results Obtained by Two Broth Dilution Methods for Susceptibility Testing of Mycobacterium avium Complex. Journal of Clinical Microbiology. 41: 627-631, 2003.
  9. El Sahly HM, Wright JA, Soini H, Bui TT, Williams-Bouyer N, Escalante P, Musser JM and Graviss EA. Recurrent Tuberculosis in Houston, Texas- A Population-Based Study. International Journal of Tuberculosis and Lung Disease. 8: 333-340, 2004.
  10. Conger NG, O’Connell R, Laurel V, Olivier K, Graviss EA, Williams-Bouyer N,
    Zhang Y and Wallace RJ Jr. Mycobacterium simiae Pseudo-outbreak Associated with a Hospital Water Supply. Infection Control and Hospital Epidemiology. 25: 1050-1055, 2004.
  11. Zhang Y, Yarkus MA, Graviss EA, Williams-Bouyer N, Turenne C, Kabani A and Wallace RJ Jr. Pulsed-field gel electrophoresis (PFGE) study of Mycobacterium abscessus isolates previously affected by DNA degradation. Journal of Clinical Microbiology. 42: 5582-5587, 2004.
  12. Biçmen C, Esen N, Graviss EA, Williams-Bouyer N, Ramaswamy SV, and Yulug N. Molecular characterization of Mycobacterium tuberculosis isolates from Izmir, Turkey. New Microbiology. 30 (3): 229-40, 2007.
  13. Franco DM, Aronson JF, Hawkins HK, Gallagher JJ, Mendoza L, and McGinnis MR and Williams-Bouyer N. Systemic Pythium insidiosum in a pediatric burn patient. In press in Burns 2009.

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