Faculty bio page2
Saravanan Thangamani, MSc, PhD

Saravanan Thangamani, MSc, PhDAssociate Professor

Department of Pathology
Vice-Chair, Institutional Animal Care and Use Committee (IACUC)
Director, Arthropod Containment Laboratories (ACL-3/-2)
Director, Insectary Services Core
Director, Tick Vector Biology Program
Cell: (409) 771-7193
Office: (409) 747-2412
Lab: (409) 747-2415
Email: sathanga@utmb.edu
Website: thangamani-lab.com

ExPath Program Faculty

Ami Murphy, DO

BS Angelo State University,
San Angelo, TX
Mathematics 2000
MPH Florida State University,
Tallahassee, FL
Public Health 2005
DO University of North Texas Health Science Center – Texas College of Osteopathic Medicine,   2012
  University of Texas Medical Branch, Galveston, TX Anatomic Pathology Residency 2015
  Harris County Institute of Forensic Sciences, Houston, TX Forensic Pathology Fellowship 2016
  Certification Anatomic Pathology  
  Certification Forensic Pathology  
  Licensure State of Texas, Q8756 Exp: 08/31/2020
Photographer of the Year, University of Texas Medical Branch, Department of Pathology Residency Program 2015
Excellence in Teaching Award, University of Texas Medical Branch, Department of Pathology Residency Program 2013
University Fellowship Scholarship, Florida State University 2004, 2005

Texas Medical Association
Texas Society of Pathologists

Teaching/Lectures:

“Introduction to Forensics”, Hitchcock High School, April 2019

“Topics in Forensic Pathology”, Justice of the Peace/Law Enforcement Workshop, Longview, TX, August 2018

“Ethics in Forensic Pathology”, Lamar University, March 2017

“Forensics Cases”, American Osteopathic College of Pathologists Live Webinar Series, June 2016

“Serotonin Syndrome: Too Much of a Good Thing”, Harris County Institute of Forensic Sciences, 2013

“Forensic Pathology Workshop”, Girl Scouts of San Jacinto Council, 2013

Poster Presentations and Abstracts:

“Synthetic Cannabinoids and Mitragynine Abuse Presenting as Pseudo-diffuse Pulmonary Hemosiderosis”, poster presentation, Texas Society of Pathologists 2015 annual meeting

“Comparison of loop-mediated isothermal amplification, real-time PCR, and enzyme immunoassay methods for toxigenic Clostridium difficile detection”, poster presentation, Texas Society of Pathologists 2013 annual meeting.  Winner, second place overall

“Infantile Hemangioma”, poster presentation, University of North Texas Health Science Center – TCOM 2011 Research Appreciation Day.  Winner, first place in Children’s Health Research 

Residency Advisory Committee

Residency Admissions Committee

Residency Directory

Peter McCaffrey, MD

Machine Learning, Artificial Intelligence, Biomedical Informatics, Computational Biology.

BA

Southern Methodist University

Philosophy, English

2009

MD

The Johns Hopkins University School of Medicine

Doctor of Medicine

2014

Residency

Harvard Medical School, The Massachusetts General Hospital

Clinical Pathology

2017

Chief Residency

Harvard Medical School, The Massachusetts General Hospital

Clinical Pathology

2016

Fellowship

Texas Medical Center

Biodesign

2018

Board Certification

American Board of Pathology

Clinical Pathology

2018

Partners Healthcare Innovation Discovery Award

2016

1st Place Medical Capital Innovation Competition

2018

Announcements

Nominations to recognize an individual who is a shining star within the research enterprise are due no later than Noon, Thursday 11/15/2018.

The CRO office will review the nominations and select a recipient to be announced at the upcoming Research Quarterly Update.  We will notify the winners vice chair the week of 11/19 so that they will be prepared to facilitate the Kudos and Highlight portion of the meeting.

Link to Nomination Form:
 https://research.utmb.edu/EOQNomination
Please contact Mary Jo D. Singleton for website design services.

Residents at Social Events

2018-2019 Residents and Fellows Goofing around on picture day
2018 Graduation Dinner
Baby Shower for Maria
Catching flounders outside the hospital
Dickens on the Strand. We even ran into some of our festive faculty.
Galveston Island Brewery is our favorite.
More fun at Galveston Island Brewery
Halloween Party 2017
Our forensics team solving mysteries with Sherlock
Sunday Funday seeing Joshua Bell
Texas Renaissance Festival is one of the largest in the US
We survived just barely.
Welcome Party on the Beach

Residents at Conferences List


Dr. Catherine Miller making friends at NAME 2017

Residents and Dr. Heather Stevenson at the 2017 TSP annual meeting

Residents and Attendings at the 2016 TSP award banquet

Cancer Biomarkers Conference II

2018 Cytopathology and Small Biopsy Update at Houston Methodist

Dr. Jianping Zhao at the 2018 TSP annual meeting

David UTMB Research Day

Dr. Brooke Blake meeting forensic pathologist Dr. Judy Melinek at NAME 2017

Drs. Maria Rivera Rolon and Mariana Moreno Prats at the 2017 TSP annual meeting

Drs. Catherine Miller and Brooke Blake at the 2017 NAME meeting

Drs. Adam Booth and Ranjana Nawgiri at CAP17

Drs. Adam Booth and Aijan Ukedeyva at the 2018 TSP annual meeting

Drs. Aaron Wyble and Adam Booth at the 2018 TSP annual meeting

Dr. Xiao-Meng Xu at the 2018 TSP annual meeting

Dr. Mariana Moreno Prats at the 2017 TSP annual meeting

Dr. Jacob Wooldridge at the 2018 TSP Annual Meeting

Dr. Jacob Wooldridge at the 2017 ASCP meeting

Dr. Adam Booth at the 2018 TSP Annual Meeting

Residents at USCAP 2018

Residents at the 2018 TSP Annual Meeting

Drs. Heather Stevenson and Adam Booth at USCAP 2018

Dr. Adam Booth representing the CAP at the 2018 AMA Annual Meeting

Dr. Adam Booth at the 2018 DDW Meeting

Dr. Adam Booth at the 2018 TSP Annual Meeting

Dr. Adam Booth at CAP17

Jing He, MD

I have a long research interest on cancer molecular biology and cancer pathogenesis. The focus of my research work have been studying the cancer biomarkers and cancer signaling pathways in carcinogenesis.
Xi’an Medical University P. R. China MD Medicine 1996
Xi’an Medical University P. R. China M Med Oncology 2000
The University of Texas Medical Branch Galveston, TX MS Biomedical Science 2006
The University of Texas Medical Branch Galveston, TX Residency Anatomic Pathology and Clinical Pathology 2015
Vanderbilt University Medical Center Nashville, TN Fellowship Surgical Pathology 2016
The University of Texas MD Anderson Cancer Center, Houston, TX Fellowship Cytopathology 2017
The University of Texas MD Anderson Cancer Center Cytopathology Staff Award 2017
United States and Canadian Academy of Pathology (USCAP) 2011- Present
College of American Pathologist (CAP) 2011- Present
American Society of Cytopathology 2016- Present
Articles
  1. He, J, Huo L, Ma J, Zhao J, Bassett R, Sun X, Ueno N, Lim B, Gong Y. Expression of Programmed Death Ligand 1 (PDL-1) in posttreatment primary inflammatory breast cancers and clinical implications. American Journal of Clinical Pathology. 2018; 149: 253-261
  2. He J, Gong Y. Epithelioid angiosarcoma: diagnostic pitfalls in fine-needle aspiration cytology. ASCP Case Reports. 2017 Dec 15th.
  3. Katsantonis N, Hunter J, O’Connell B, He, J, Lewis J, Wanna G. Temporal Bone Mucormycosis.Annals of Otology, Rhinology & Laryngology. 2016.
  4. Zhang Z, Finnerty CC, He J, Herndon DN. Smad Ubiquitination Regulatory Factor 2 Expression is Enhanced in Hypertrophic Scar Fibroblasts from Burned Children. Burns. 2012 Mar; 38(2):236-246. PMID: 21920670
  5. Yang L, He J, Huang S, Zhang X, Bian Y, He N, Zhang H, and Xie J. Activation of Hedgehog Signaling isnot a Frequent Event in Ovarian Cancers. Molecular Cancer. 2009 Nov 27; 8:112. PMID: 1994394119943941.
  6. He J, Sheng T, Stelter AA, Li C, Zhang X, Sinha M, Luxon BA, and Xie J. Suppressing Wnt Signaling by the Hedgehog Pathway through sFRP-1. The Journal of Biological Chemistry. 2006 Nov 24; 281(47):35598-35602. PMID: 17035233.17035233
  7. Huang S, He J (Co-first author), Zhang X, Bian Y, Yang L, Xie G, Zhang K, Tang W, Stelter AA, Wang Q, Zhang H, Xie J. Activation of the Hedgehog Pathway in Human Hepatocellular Carcinomas. Carcinogenesis. 2006 Jul; 27(7):1334-1340. PMID: 1650125316501253.
  8. Ma X, Sheng T, Zhang Y, Zhang X, He J, Huang X, Chen K, Sultz J, Adegboyega PA, Zhang H, Xie J. Hedgehog Signaling is Activated in Subsets of Esophageal Cancers. International Journal of Cancer, 2006 Jan 1; 118(1):139-148. PMID: 1600373716003737.
  9. Yang DZ, He J, Zhang JC, Wang ZR. Expression of Angiostatin cDNA in Human Gallbladder Carcinoma Cell Line GBC-SD and its Effect on Endothelial Proliferation and Growth. World Journal of Gastroenterology, 2006 May 7; 12(17):2762-2766. PMID: 16718765.
  10. Yang DZ, He J, Zhang JC, Wang ZR. Angiostatin Inhibits Pancreatic Cancer Cell Proliferation and Growth in Nude Mice. World Journal of Gastroenterology, 2005 Aug 28; 11(32):4992-4996. PMID: 16124051.
  11. Yang DZ, He J, et al. Expression of MMP-9 in Cholangiocarcinoma and their Significance, Journal of Practice Oncology, 2004; 18(2): 95.
  12. Yang DZ, He J, et al. Expression of E-cadherin in Carcinoma of Gallbladder and its Relationship with the Invasion and Metastasis. Shaanxi Medical Journal, 2004; 33(2):111.
  13. Xiao J, Han M, He J, et al. Expression of Thymidine Phosphorylase and Lung Resistance Protein in Human Colorectal Carcinoma and its Clinical Significance, West China Medical Journal, 2004; 19(1): 24.
  14. Qin T, Gao Y, He J, et al. Combined Administration with Huachansu and Chemotherapy for Gastrointestinal Cancer, Shaanxi Traditional Medicine, 2002; 23(1): 35.
  15. Qin T, Gao Y, Xiao J, He J, et al. Combination Chemotherapy with IAP, MVP in Non-small-cell Lung Cancer, Journal of Xi’an Medical University, 2002; 23(1): 82.
  16. Yang DZ, He J, et al. The FAS Signaling Pathway and Cancer, Journal of Medical Laboratory Science, 2000; 15(4): 63.
  17. Yang DZ, He J, et al. Expression of Apoptosis Related Protein in Cholangio- carcinoma and its Significance. Shaanxi Medical Journal, 2000; 29(12): 720.
  18. Yang DZ, He J, et al. The Expression of BAX Protein and FAS Antigen in Cholangiocarcinoma and its Significance. Shaanxi Oncology Medicine, 1999; 7(4): 208.
Book Chapters
  1. He J. “Calcifying Fibrous Pseudotumor of Pleura”. In J.H. van Krieken (Ed.), Encyclopedia of Pathology. 2018; Berlin, Heidelberg: Springer.
  2. He J, Nan K, “Solid Tumors in Children”. In: Kejun Nan, ed. Modern Tumor Therapeutics, Beijing: World Publishing Corporation, 2003; Chapter 46: P657-675.

Christopher J. Zahner, MD

Dr. Zahner's basic research has focused on medical devices and resulted in hardware development, grants, and patents in the fields of balance, acoustics, sample processing, and microbial growth, along with prototype hardware in sample tracking and hand hygiene. His clinical research is focused on diagnostic error using the diagnostic management team and mobile app development.
University of Florida MS Mechanical Engineering 2005
Texas Tech Health Sciences Center MD Medicine 2015
University of Texas Medical Branch CP Pathology 2018
United Space Alliance – Employee of the Year 2008

Usama A. Yassi, MD

My interest is in finding the significance of increased plasma cells in cases of microscopic colitis.

Almustansiriyah College of Medicine – Baghdad, Iraq

MBChB

Medicine and Surgery

2004

University of South Dakota – Sioux Falls, South Dakota

 

Anatomic and Clinical Pathology

2017

University of Texas Medical Branch – Galveston, Texas

 

Surgical Pathology

2018

Gbo Yuoh award in recognition of commitment to teaching pathology residents. 2017
College of American Pathologists 2013

United States and Canadian Academy of Pathology 2017

Tjarks, B.J., Yassi, U., Jassim, A.D: A rare case of primary cutaneous osteosarcoma. Abstracts and Case Studies from the College of American Pathologists 2015 Annual Meeting (CAP '15). Archives of Pathology & Laboratory Medicine. 139(10):e82, 2015

Usama Yassi, MD; Amy Kerkvliet, MD; RJ Summerer, DO; Ali Jassim, MD, PhD. Eccrine Spiradenoma, lymphangiectatic variant. Platform presentation, 18th joint ISDP meeting, San Francisco, CA, 2015. South Dakota medical journal. Vol. 69 Issue 8, p359-361. 3p.

Vasantha Gali, MD; Usama Yassi, MD; Sarah Sarbacker,MD; Ali Jassim, MD, PhD. Cutaneous glomeruloid hemangioma: a report on two cases and a review of literature. South Dakota medical journal. Vol. 70 Issue 6, p250-251.

Vasantha Gali, MD; Usama Yassi, MD; Ali Jassim, MD, PhD. Desmoplastic dermatofibrosarcoma protuberans. ASDP case of the month, November 2016.

Michael Laposata, MD, PhD

  • I have had a long interest on laboratory test utilization, particularly as it relates to coagulation studies, my area of expertise. A principal focus of the work has been the identification of diagnostic errors and mechanisms to prevent them.
  • I have been a fatty acid biochemist for 35 years. My early research career included the study of biological mechanisms associated with the conversion of fatty acids into eicosanoids. The focus was to identify the pool of eicosanoid precursor fatty acids in the cell and how they became available for eicosanoid production. I later investigated the covalent association of fatty acids to proteins by thioester linkages with Dr. Laszio Muszek, who was later elected to the Hungarian National Academy of Sciences. My laboratory also included fatty acid related studies involved an esterification product of ethanol and fatty acids, fatty acid ethyl esters (FAEE), and fatty acid abnormalities found in patients with cystic fibrosis.
  • I have continuously written articles on topics related to diagnosis of coagulation disorders and optimization of clinical laboratory operations. This led to the production of several books, including a major textbook entitled Laboratory Medicine: The Diagnosis of Disease in the Clinical Laboratory, published by McGraw-Hill in the prestigious Lange series of medical textbooks. The third edition has been named Laposata’s Laboratory Medicine.
BA Bucknell University Lewisburg, PA 1974
MD Johns Hopkins University School of Medicine Baltimore, MD 1981
PhD Johns Hopkins University School of Medicine Baltimore, MD 1982
Residency Division of Laboratory Medicine,
Departments of Pathology and Medicine
Washington University School of Medicine
St. Louis, MO
1985

Certification: Diplomate, American Board of Pathology

1988-89 Christian R. and Mary F. Lindback Distinguished Teaching Award, University of Pennsylvania School of Medicine (2 medical school faculty selected annually)
1989 University of Pennsylvania School of Medicine Commencement Speaker (one faculty member selected by vote of graduating class of 1989)
1998 A. Clifford Barger Excellence in Mentoring Award, Harvard Medical School (4 awardees selected among hundreds of nominated faculty members)
1999, 2000, 2005 Award for Most Distinguished Teacher in the Preclinical Years, Harvard Medical School (1 awardee by the vote of the graduating class)
2005 Award from the Institute for Quality in Laboratory Medicine (IQLM) of the Centers for Disease Control and Prevention (CDC) for “Improved Clinical Integration” of Laboratory Medicine Services. One of 10 major awards in 2005 by the IQLM.
2006 - 2007 Boston Magazine’s Best of Boston Doctors (Top 100-200 local physicians among  5000 licensed doctors)
2014-2016 National Academy of Medicine Committee on Diagnostic Error in Medicine
2015 The Pathologists’ 2015 Pathologist Power List, #3 globally, #1 in US (The Pathologists Issue 13, 2015)

Sean G. Yates, MD

My research efforts are aimed at improving patient safety and clinical outcomes, while also reducing the need for allogeneic blood components and provide insight and helping foster development of diagnostic and prognostic testing to further the advancement of patient blood management and support hemorrhagic and thrombotic diseases.
BS Texas Tech University, Lubbock, TX 2005
MD University of Texas Health Sciences Center at Houston, Houston, TX 2011
Residency University of Texas Southwestern, Dallas, TX 2014
Fellowship University of Texas Southwestern, Dallas, TX 2015
Travel Award South Central Association of Blood Banks; Las Vegas, NV 2015
Travel Award Thrombosis and Hemostasis Summit of North America; Chicago, IL 2014
Teaching Award, Medical Student Curriculum University of Texas Southwestern Medical Center, Dallas, TX 2014
Society for the Advancement of Blood Management 2018 – Present
AABB 2014 – Present
International Society on Thrombosis and Haemostasis 2014 – Present

Reddy M, Tawfik B, Gavva C, Yates S, De Simone N, Hofmann SL, Rambally S, Sarode R. Ischemic stroke in a patient with moderate to severe inherited factor VII deficiency. Transfus Apher Sci. 2016 Dec;55(3):364-367. doi: 10.1016/j.transci.2016.10.002. Epub 2016 Oct 17. PubMed PMID: 27776919.

Related citations

Yates SG, Smith S, Tharpe W, Shen YM, Sarode R. Can an anti-Xa assay for low-molecular-weight heparin be used to assess the presence of rivaroxaban? Transfus Apher Sci. 2016 Oct;55(2):212-215. doi: 10.1016/j.transci.2016.06.005. Epub 2016 Jun 27. PubMed PMID: 27377884.

Cited in PMCRelated citations

Gavva C, Yates SG, Rambally S, Sarode R. Transfusion management of factor V deficiency: three case reports and review of the literature. Transfusion. 2016 Jul;56(7):1745-9. doi: 10.1111/trf.13623. Epub 2016 Apr 28. PubMed PMID: 27125565.

Cited in PMCRelated citations

Shen YM, Tsai J, Taiwo E, Gavva C, Yates SG, Patel V, Frenkel E, Sarode R. Analysis of Thrombophilia Test Ordering Practices at an Academic Center: A Proposal for Appropriate Testing to Reduce Harm and Cost. PLoS One. 2016 May 13;11(5):e0155326. doi: 10.1371/journal.pone.0155326. eCollection 2016. PubMed PMID: 27176603; PubMed Central PMCID: PMC4866738.

Free full textCited in PMCRelated citations

Joseph R, Burner J, Yates S, Strickland A, Tharpe W, Sarode R. Thromboembolic outcomes after use of a four-factor prothrombin complex concentrate for vitamin K antagonist reversal in a real-world setting. Transfusion. 2016 Apr;56(4):799-807. doi: 10.1111/trf.13406. Epub 2015 Nov 20. PubMed PMID: 26589481.

Cited in PMCRelated citations

Yates SG, Gavva C, Agrawal D, Sarode R. How do we transfuse blood components in cirrhotic patients undergoing gastrointestinal procedures? Transfusion. 2016 Apr;56(4):791-8. doi: 10.1111/trf.13495. Epub 2016 Feb 15. PubMed PMID: 26876945.

Related citations

 Yates S, Sarode R. Reversal of anticoagulant effects in patients with intracerebral hemorrhage. Curr Neurol Neurosci Rep. 2015 Jan;15(1):504. doi: 10.1007/s11910-014-0504-2. Review. PubMed PMID: 25407132.

Cited in PMCRelated citations

 Yates S, Matevosyan K, Rutherford C, Shen YM, Sarode R. Bortezomib for chronic relapsing thrombotic thrombocytopenic purpura: a case report. Transfusion. 2014 Aug;54(8):2064-7. doi: 10.1111/trf.12614. Epub 2014 Mar 24. PubMed PMID: 24655327.

Cited in PMC Related citations

 Yates SG, Sarode R. Is platelet transfusion necessary in cirrhotic patients with splenomegaly? Liver Int. 2014 Jan;34(1):164-5. doi: 10.1111/liv.12332. Epub 2013 Oct 16. PubMed PMID: 24102873.

Related citations

 Yates S, Sarode R. Novel thrombin and factor Xa inhibitors: challenges to reversal of their anticoagulation effects. Curr Opin Hematol. 2013 Nov;20(6):552-7. doi: 10.1097/MOH.0b013e328365a164. Review. PubMed PMID: 24104417

Vasilakis Current Lab Members

Curriculum Vitae

Present Position and Address

Doctoral Candidate
University of Texas Medical Branch at Galveston
Institute for Translational Sciences
Human Pathophysiology and Translational Medicine
301 University Blvd.
Galveston TX, 77555-1019
srazar@utmb.edu

Education

08/2014-Present Graduate Student
Human Pathophysiology and Translational Medicine
Institute for Translational Sciences
University of Texas Medical Branch, Galveston, TX
08/2011-06/2013 Master’s of Science in Biomedical Sciences
University of California Riverside, Riverside, CA
08/2007-06/2011 Bachelor’s of Science in Microbiology (Major) and Psychology (Minor)
University of California San Diego, San Diego, CA

Professional and Teaching Experience

01/2016-Present Graduate Student
Institute for Translational Sciences
University of Texas Medical Branch, Galveston TX
Mentor: Dr. Scott C. Weaver
Project: "Bloodmeal determinants of arbovirus infection of Aedes (Stegomyia) spp. mosquitoes"
11/2012-3/2013 Graduate Student
Department of Biomedical Sciences
University of California Riverside, Riverside, CA
Mentor: Dr. Christian Lytle, PhD
Project: “Colonic mucus regulation in homeostasis and disease”
03/2012-10/2012 Graduate Student
Department of Biomedical Sciences
University of California Riverside, Riverside, CA
Mentor: Dr. David Lo, MD, PhD
Project: “Role of tight junction proteins in non-canonical large particle endocytosis”
10/2009-08/2011 Undergraduate Researcher
Department of Pathology
University of California San Diego, San Diego, CA
Mentor: Dr. Dwayne Stupack, PhD
Project: “Role of Src family kinases and Focal Adhesion kinase in neuroblastoma resistance to anoikis in 3-dimensional cell culture models”
Training/Supervision of Undergraduate, Graduate, and Medical Students
04/2018-04/2018 Hands-On Trainer for Viral Isolation and Quantification; Vector Borne Disease Course, Western Gulf Center of Excellence for Vector Borne Disease
01/2018-02/2018 Barbara Chaves, Graduate Student, Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil
10/2017-12/2018 Ana Carolina Terzian, PhD. Faculdade de MedicFaculdade de Medicina de São José do Rio Preto | FAMERP
6/2016-8/2016 Scott Segura, Undergraduate: University of Texas Dallas, Summer
Undergraduate Research Program (SURP)

Memberships in Scientific Societies

04/2016-Present Member: American Society for Tropical Medicine and Hygiene
04/2016-Present Member: American Society of Microbiology
03/2017-Present Member: American Society of Virology

Academic and Professional Honors
James W. McLaughlin Annual Colloquium: Poster Session Travel Award, March 31, 2017
McLaughlin Predoctoral Fellow: September 1, 2017 to present

Bibliography

Abstracts

  1. Azar SR, Rossi SL, Haller SL, Yun R, Leal G, Zhou J, Huang J, Hanley KA, Weaver SC, Vasilakis NV. Zika virus demonstrates minimal pathology and mosquito infectivity in viremic cynomolgus macaques. Poster at the PanAmerican Dengue Research Network Meeting. Galveston, TX, April 9-12, 2018
  2. Azar SR, Roundy CM, Rossi SL, Huang JH, Yun R, Hanley KA, Vasilakis N, Weaver SC. Vector competence analysis of Aedes (Stegomyia) spp. mosquitoes from the Americas for Zika Virus. Poster at International Union of Microbiological Societies 2017.  Singapore, Singapore, July 17-21, 2017
  3. Azar SR, Roundy CM, Rossi SL, Huang JH, Yun R, Hanley KA, Vasilakis N, Weaver SC. Vector competence of American Aedes albopictus (Skuse)  populations for various strains of Zika virus. Poster at Sao Paulo School of Advanced Sciences: Arbovirology, Sao Jose do Rio Preto, Brazil, May 29, 2017
  4. Azar SR, Roundy CM, Rossi SL, Huang JH, Yun R, Hanley KA, Vasilakis N, Weaver SC. Vector competence of American Aedes albopictus (Skuse)  populations for various strains of Zika virus. Poster at Annual McLaughlin Symposium, Galveston, TX, March 31, 2017.
  5. Azar SR, Roundy CM, Rossi SL, Huang JH, Yun R, Hanley KA, Vasilakis N, Weaver SC. Vector competence analysis of Aedes (Stegomyia) spp. mosquitoes from the Americas for Zika Virus. Poster at Gordon Research Conference: Tropical Infectious Diseases, Galveston, TX, March 13-14, 2017
  6. Azar SR,  Tesh RB,  Muruato AE, Hanley KA, Auguste AJ, Langsjoen RM, Paessler S, Vasilakis N, Weaver SC, Rossi SL (2016). Development and Characterization of a Small Animal Model of Zika Virus infection. Poster at Annual McLaughlin Symposium, Galveston, TX, April 2016.

Publications in Peer Reviewed Journals:

  1. Vanchiere JA, Ruiz JC, Brady AG, Kuehl TJ, Williams LE, Bazar WB, Wilkerson GK, Nehete PN, McClure GB, Rogers DL, Rossi SL, Azar SR, Roundy CM, Weaver SC, Vasilakis N, Simmons JH, Abee CR, 2017. Experimental Zika Virus Infection of Neotropical Primates. Am J Trop Med Hyg. (Published Online Ahead of Print) doi: 10.4269/ajtmh.17-0322
  2. Roundy CM, Azar SR, Brault AC, Ebel GD, Failloux A, Fernandez-Salas I, Kitron U, Kramer LD, Lourenço-de-Oliveira R, Osorio JE, Paploski ID, Vazquez-Prokopec GM, Ribeiro GS, Ritchie SA, Tauro LB, Vasilakis, Weaver SC, 2017. Lack of evidence for Zika virus transmission by Culex mosquitoes. Emerg Microbes Infect 6: e90.doi: 10.1038/emi.2017.85.
  3. Azar SR, Roundy CM, Rossi SL, Huang JH, Leal G, Yun R, Fernandez-Salas I, Vitek CJ, Paploski IAD, Stark PM, Vela J, Debboun M, Nava MR, Kitron U, Ribeiro GS, Hanley KA, Vasilakis N, Weaver SC. Differential vector competency of Aedes albopictus populations from the Americas for Zika virus. Am J Trop Med Hyg 97: 330-339. doi: 10.4269/ajtmh.16-0969
  4. Zhao Z, Yang M, Azar SR, Soong L, Weaver SC, Sun J, Chen Y, Rossi SL, Cai J, 2017. Viral Retinopathy in Experimental Models of Zika Infection. Invest Ophthalmol Vis Sci 58: 4075–4085. doi:  10.1167/iovs.17-22016
  5. Roundy CM, Azar SR, Rossi SL, Huang JH, Leal G, Yun R, Fernandez-Salas I, Vitek CJ, Paploski IAD, Kitron U, Ribeiro GS, Hanley KA, Weaver SC, Vasilakis N, 2017. Variation in Aedes aegypti competence for Zika virus transmission as a function of viral strain, blood meal type, and mosquito geographic origin. Emerg Infect Dis 23: 625-632. doi: 10.3201/eid2304.16148
  6. McGrath EL, Rossi SL, Gao J, Widen SG, Grant AC, Dunn TJ, Azar SR, Roundy CM, Xiong Y, Prusak DJ, Loucas BD, Wood TG, Yu Y, Fernandez-Salas I, Weaver SC, Vasilakis N, Wu P, 2017. Differential Responses of Human Fetal Brain Neural Stem Cells to Zika Virus Infection. Stem Cell Rep. doi:10.1016/j.stemcr.2017.01.008
  7. Hart CE, Roundy CM, Azar SR, Huang JH, Yun R, Reynolds E, Leal G, Nava MR, Vela J, Stark PM, Debboun M, Rossi SL, Vasilakis N, Thangamani S, Weaver SC, 2017. Zika Virus Vector Competency of Mosquitoes, Gulf Coast, United States. Emerg Infect Dis 23: 559–560.
  8. Vinhaes ES, Santos LA, Dias L, Andrade NA, Bezerra VH, de Carvalho AT, de Moraes L, Henriques DF, Azar SR, Vasilakis N, Ko AI, Andrade BB, Sigueira IC, Khouri R, Boaventura VS, 2016. Transient Hearing Loss in Adults Associated with Zika Virus Infection. Clin Infect Dis: doi:10.1093/cid/ciw770
  9. Guerbois M, Fernandez-Salas I, Azar SR, Danis-Lozano R, Alpuche-Aranda CM, Leal G, Garcia-Malo IR, Diaz-Gonzalez EE, Casas-Martinez M, Rossi SL, Del Río-Galván SL, Sanchez-Casas RM, Roundy CM, Wood TG, Widen SG, Vasilakis N, Weaver SC, 2016. Outbreak of Zika virus infection, Chiapas State, Mexico, 2015, and first confirmed transmission by Aedes aegypti mosquitoes in the Americas. J Infect Dis: Pii: jiw302
  10. Smalley C, Bechelli J, Brouwer D, Saito TB, Azar SR, Ismail N, Walker DH, Fang R, 2016. Rickettsia australis Activates ASC-Dependent Inflammasome in Macrophages Only Transiently Involving NLRP3. PLoS One 11:e0157231
  11. Shan C, Xie X, Muruato AE, Rossi SL, Roundy CM, Azar SR, Yang Y, Tesh RB, Bourne N, Barrett AD, Vasilakis N, Weaver SC, Shi PY, 2016. An infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors. Cell Host Microbe 19:891-900
  12. Rossi SL, Tesh RB, Azar SR, Muruato AE, Hanley KA, Auguste AJ, Langsjoen RM, Paessler S, Vasilakis N, Weaver SC, 2016. Characterization of a Novel Murine Model to Study Zika Virus. Am J Trop Med Hyg 94:1362-9
  13. Ponsnusamy D, Kozlova EV, Sha J, Erova TE, Azar SR, Fitts EC, Kirtley ML, Tiner BL, Andersson JA, Grim CJ, Isom RP, Hasan NA, Colwell RR, Chopra AK, 2016. Cross-talk among flesh-eating Aeromonas hydrophila strains in mixed infection leading to necrotizing fasciitis. Proc Natl Acad Sci USA 113:722-7

Book Chapters

  1. Roundy CM, Azar SR, Rossi SL, Weaver SC, Vasilakis N, 2017. Insect-Specific Viruses: A Historical Overview and Recent Developments. Adv Virus Res 98: 119-146

Invited Presentations

  1. Azar SR. Vector competence analysis of Aedes (Stegomyia) spp. mosquitoes from the Americas for Zika Virus. Invited Oral presentation: International Collaboration in Infectious Disease Research: Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil, March 19, 2018
  2. Azar SR.The A129 mouse model of Zika Virus Infection: Initial characterization and subsequent applications. Invited oral presentation: AALAS National Meeting, Session: “Sex, Blood & Babies: Animal Models of Zika Virus Research”, Austin, TX, October 17, 2017
  3. Azar SR. Vector competence analysis of Aedes (Stegomyia) spp. mosquitoes from the Americas for Zika Virus. Invited Oral presentation: Gordon Research Conference: Tropical Infectious Diseases, Galveston, TX, March 14, 2017
Curriculum Vitae

Current position

Research Fellow
Department of Pathology
University of Texas Medical Branch
301 University Boulevard
Galveston TX-77555
adhendy@utmb.edu

Education

11/2013-02/2018 PhD
Biomedical Sciences
Institute of Tropical Medicine/University of Antwerp, Antwerp, Belgium
09/2011-09/2012 MSc
Biology and Control of Disease Vectors
London School of Hygiene & Tropical Medicine, London, UK
09/2001-06/2004 BSc Biological Sciences and Parasitology
King’s College London, London, UK

Professional Experience

02/2018 - Present Research Fellow
Department of Pathology
University of Texas Medical Branch, Galveston, TX
Supervisor: Prof. Nikos Vasilakis
Project: Transmission and emergence dynamics of emerging zoonotic arboviruses.
11/2013 - 1/2018 Predoctoral Assistant
Department of Biomedical Sciences
Institute of Tropical Medicine, Antwerp, Belgium
Supervisors: Prof. Jean-Claude Dujardin, Prof. Dirk Berkvens
Project: Blackfly ecology and Onchocerca volvulus transmission in three formerly hyperendemic foci in Uganda, Tanzania and Cameroon.
01/2013 - 10/2013 Education and Research Assistant
Department of Life Sciences
Natural History Museum, London, UK
Supervisors: Dr. John Tweddle, Dr. Erica McAlister
Project I: Delivering educational programmes in insect ecology and botany on behalf of the Natural History Museum to Cothill Education Trust.
Project II: Developing a pictorial identification key for nine species of Aedes (Albuginosus) mosquitoes.
02/2010 - 09/2011 Research Assistant/Volunteer
Department of Life Sciences
Natural History Museum, London, UK
Supervisors: Dr Mark Spencer, Dr. Erica McAlister
Project I: Modelling the impact of climate-related events on plant and animal phenology using data held in museum collections.
Project II: Identification of spirit-preserved insects collected in French Guiana.

Academic and Professional Awards

FWO Travel Grant: Awarded funding for a one-month research stay at Clemson University, SC (2015).
Flemish Government SOFI Grant: Awarded €665,038 (as co-applicant) for the project "An interdisciplinary study contributing to the identification of the cause of nodding syndrome in four countries" (2014).
John Spedan Lewis Foundation: Awarded £5,000 to study the morphology, phylogenetics and bionomics of Aedes (Albuginosus) mosquitoes (2013).
Mansfield Aders Scholarship: Awarded tuition fees to study a master’s degree at the London School of Hygiene & Tropical Medicine (2011).

Conferences and Presentations

10th European Congress on Tropical Medicine and International Health (ECTMIH), 2017. Antwerp, Belgium. "The blackfly vectors and transmission of Onchocerca volvulus in Mahenge, south eastern Tanzania." Oral presentation.

10th European Congress on Tropical Medicine and International Health (ECTMIH), 2017. Antwerp, Belgium. "Esperanza Window Traps for the collection of anthropophilic blackflies (Diptera: Simuliidae) in Uganda and Tanzania." Poster presentation.

1st International Workshop on Onchocerciasis Associated Epilepsy (OAE), 2017. Antwerp, Belgium. "Blackfly ecology and O. volvulus transmission in Uganda, Tanzania and Cameroon." Oral presentation.

1st International Workshop on Onchocerciasis Associated Epilepsy (OAE), 2017. Antwerp, Belgium. "The blackfly vectors and transmission of Onchocerca volvulus in Mahenge, south eastern Tanzania." Poster presentation.

2nd International Conference on Nodding Syndrome, 2015. Gulu, Uganda. "Blackflies (Diptera: Simuliidae) and Onchocerca infection in Nodding Syndrome-affected districts of northern Uganda." Oral Presentation.

13th Annual North American Black Fly Association (NABFA) Meeting, 2015, Athens, Georgia, USA. "Investigating a relationship between blackflies (Diptera: Simuliidae), onchocerciasis and Nodding Syndrome: An entomological perspective." Oral Presentation.

Publications

Hendy, A., Krüger, A., Pfarr, K., De Witte, J., Kibweja, A., Mwingira, U., Dujardin, J.C., Post, R., Colebunders, R., O’Neill, S. & Kalinga, A., 2018. The blackfly vectors and transmission of Onchocerca volvulus in Mahenge, south eastern Tanzania. Acta Tropica, 181, pp.50-59. https://doi.org/10.1016/j.actatropica.2018.01.009  
Hendy, A., Sluydts, V., Tushar, T., De Witte, J., Odonga, P., Loum, D., Nyaraga, M., Lakwo, T., Dujardin, J.C., Post R.J., Kalinga, A. & Echodu, R., 2017. Esperanza Window Traps for the collection of anthropophilic blackflies (Diptera: Simuliidae) in Uganda and Tanzania. PLOS Neglected Tropical Diseases, 11(6): e0005688. https://doi.org/10.1371/journal.pntd.0005688
Colebunders, R., Hendy, A. & van Oijen, M., 2014. Nodding syndrome in onchocerciasis endemic areas. Trends in Parasitology. https://doi.org/10.1016/j.pt.2016.05.013 
Orsborne, J., DeRaedt Banks, S., Hendy, A., Gezan, S.A., Kaur, H., Wilder-Smith, A., Lindsay, S.W. & Logan, J.G., 2016. Personal protection of permethrin-treated clothing against Aedes aegypti, the vector of dengue and Zika virus, in the laboratory. PLOS ONE, 11(5): e0152805. https://doi.org/10.1371/journal.pone.0152805  
Colebunders, R., Hendy, A., Mokili, J., Wamala, J., Kaducu, J., Kur, L., Tepage, F., Mandro, M., Mucinya, G., Mambandu, G., Komba, M., Lumaliza, J., van Oijen, M. & Laudisoit, A., 2016. Nodding syndrome and epilepsy in onchocerciasis endemic regions: comparing preliminary observations from South Sudan and the Democratic Republic of the Congo with data from Uganda. BMC Research Notes, 9:182. https://doi.org/10.1186/s13104-016-1993-7
Deblauwe, I., Demeulemeester, J., De Witte, J., Hendy, A., Sohier, C. & Madder, M., 2015. Increased detection of Aedes albopictus in Belgium: no overwintering yet, but an intervention strategy is still lacking. Parasitology Research, 114, pp.3469–3477. https://doi.org/10.1007/s00436-015-4575-z
Colebunders, R., Post, R., O’Neill, S., Haesaert, G., Opar, B., Lakwo, T., Laudisoit, A. & Hendy, A., 2015. Nodding syndrome since 2012: recent progress, challenges and recommendations for future research. Tropical Medicine & International Health, 20(2), pp.194-200. https://doi.org/10.1111/tmi.12421
Colebunders, R., Hendy, A., Nanyunja, M., Wamala, J.F. & van Oijen, M., 2014. Nodding syndrome—a new hypothesis and new direction for research. International Journal of Infectious Diseases, 27, pp.74-77. http://dx.doi.org/10.1016/j.ijid.2014.08.001
Demeulemeester, J., Deblauwe, I., De Witte, J., Jansen, F., Hendy, A. & Madder, M., 2014. First interception of Aedes (Stegomyia) albopictus in Lucky bamboo shipments in Belgium. Journal of the European Mosquito Control Association, 32, pp.14-16.

Curriculum Vitae

Appointment: Research Associate II
Professional Education

2005 M.S. Latrobe University, Australia Health Administration
1993 B.S. Capital Medical University, China Senior Nursing Profession
Research Interests Basic research on the genetics, ecology, evolution and pathogenesis of arthropodborne
viruses (arboviruses), virusmosquito interactions, and vaccine development.

Professional Experience

12.17.2015- Present Research Associate II, Department of Pathology,
University of Texas Medical Branch, Galveston, TX
12.15.2014 -12.16.2016 Research Fellow, Department of Pediatrics,
University of Texas Medical Branch, Galveston, TX
10.24.2014 – 12.14.2014 Visiting Scientist, Department of Pathology,
University of Texas Medical Branch, Galveston, TX
08.2013 – 10.2014 Research Assistant, Department of Public Health,
Harbin Medical University of Heilongjiang, China

Selected Publications

Zhou Jiehua, Liu S, Fu Y, Chen Y, Silver AJ, Hill SM, Lee I, Lee YS, and Bao X.
"Identification of two novel functional tRNA-derived fragments induced in response toRSV infection", J Gen Virol. 2017 Jul

Chen Y, Deng X, Deng J, Zhou Jiehua, Ren Y, Prusak,DJ, Wood TG, and Bao X. "Functional Motif Responsible for Human Metapneumovirus M2-2-mediated InnateImmune Evasion". Virology. 2016, accepted

Deng J, Ptashkin RN, Chen Y, Cheng Z, Liu G, Phan T, Deng X, Zhou J, Lee I, Lee YS, Bao X. "Respiratory Syncytial Virus Utilizes a tRNA Fragment to Suppress Antiviral Responses Through a Novel Targeting Mechanism." Mol Ther. 2015 Oct;23(10):1622-9

Jack Alperin, MD

The clinical investigation of problems related to benign diseases of the blood (e.g. hemostasis & thrombosis, hemoglobinopathies, anemia, thrombocytopenia).
MD College of Medicine, University of Tennessee Medicine 1957
Internship

Michael Reese Hospital, Chicago, Illinois

Internal Medicine Residency, and Hematology Fellowship 1963
Fellowship University of Texas Medical Branch, Galveston, Texas Senior Hematology Research Fellow 1965
2001 Inaugural Scholar in the John P. McGovern Academy of Oslerian Medicine, University of Texas Medical Branch, Galveston, Texas
2005 Laureate Award, Texas Chapter, American College of Physicians
  • American Society of Hematology
  • Texas and American Medical Associations
  • Galveston County Medical Society
  • American Osler Society
  • American College of Physicians
  • International Society of Thrombosis and Haemostasis
  • International Society of Haemotology
  • American Association of Blood Banks

Natalie Williams-Bouyer, PhD

Antimicrobial resistance trends. Antimicrobial resistance trends have been a long standing interest of mine. I am particularly interested in the origins of microorganisms that acquire multiple antibiotic resistance. Individuals infected with drug-resistant organisms are more likely to have longer hospital stays and require treatment with second- or third-generation drugs that may be more toxic, and/or more expensive. Therefore, the intent of my research is to utilize molecular techniques to study the epidemiology of multidrug-resistant organisms (MDRO), as a means of prevention and control of infections caused by these microbes. Ideally, these methods will lead to an improved efficacy in the characterization of antimicrobial resistant organisms isolated in the clinical microbiology laboratory.
BS University of Southwest Louisiana,
Lafayette, LA
Microbiology 1989
PhD Meharry Medical College, Nashville, TN Microbiology 1997
Post-Doctoral Fellow University of Texas Medical Branch, Galveston, TX Clin/Public Health Microbiology 1999
1998 American Society for Microbiology Student Travel Award
1997 Who's Who Among Students in American Universities and Colleges
1995-1997 National Science Foundation Research Center of Excellence of Meharry Medical College (MRCE) Fellowship
1995 Who's Who Among Students in American Universities and Colleges
1994 American Society for Microbiology Supplemental Fellowship
1993 American Society for Microbiology Student Travel Award
1992-1995 Patricia Roberts Harris Fellowship
1990-1992 Minority Biomedical Research Support (MBRS) Program Fellowship

Appointments
2007-Present Assistant Director Division of Clinical Microbiology, Department of Pathology, University of Texas Medical Branch, Galveston, Texas
2005-Present Assistant Professor Department of Pathology, University of Texas Medical Branch, Galveston, Texas
2005-2009 Director Clinical Laboratory Services, Shriners Hospitals for Children, Galveston, Texas
2004-2005 Assistant Bureau Chief Clinical Services Section, Bureau of Laboratory Services, Houston Department of Health and Human Services, Houston, Texas
2001-2004 Research Associate/
Laboratory Manager
Houston Tuberculosis Initiative, Department of Pathology, Baylor College of Medicine, Houston, Texas
1999-2001 Clinical Instructor Division of Clinical Microbiology, Department of Pathology, University of Texas Medical Branch, Galveston, Texas
1999-1999 Acting Director Parasitology , Division of Clinical Microbiology, Department of Pathology, University of Texas Medical Branch, Galveston, Texas
1999-1999 Course Laboratory Assistant Pathobiology and Host Defense Laboratory, University of Texas Medical Branch, Galveston, Texas
1998-1999 Microbiology Lab Contact CDC National Nosocomial Infections Surveillance System- Intensive-Care Antimicrobial Resistance Epidemiology (ICARE), University of Texas Medical Branch, Galveston, Texas
1997-1998 Study Coordinator Swab Equivalency Study for the Collection of Female Endocervical Specimens (Gen-Probe Inc.), University of Texas Medical Branch, Galveston, Texas
1992-1993 Medical Microbiology Laboratory Instructor Department of Microbiology, Meharry Medical College, Nashville, Tennessee
1990-1997 Graduate Research Assistant Department of Microbiology, Meharry Medical College, Nashville, Tennessee
2008-Present Society for Healthcare Epidemiology of America
2006-2008 American Burn Association
2006-2008 International Society for Burn Injuries
2005-Present Clinical Laboratory Management Association
2005-Present Association of Public Health Laboratories
1995-1997 American Society for Clinical Laboratory Science
1990-1997 Sigma Delta Epsilon/Graduate Women in Science
1988-Present American Society for Microbiology
  1. Williams-Bouyer NM and McGinnis Hill E. Involvement of host cell tyrosine phosphorylation in the invasion of HEp-2 cells by Bartonella bacilliformis. FEMS Microbiology Letters 171:191-201, 1999.
  2. Williams-Bouyer N, Reisner BS, Woodmansee CE, Falk PS and Mayhall CG. Comparison of the Vitek GPS-TB card to disk diffusion testing for predicting the susceptibility of enterococci to vancomycin. Archives of Pathology and Laboratory Medicine 123:622-625, 1999.
  3. Williams-Bouyer N, Hernandez A and Reisner BS. Predicting the susceptibility of Streptococcus pneumoniae to ceftriaxone and cefotaxime by cefuroxime and ceftizoxime disk diffusion testing. Journal of Clinical Microbiology 37:3707-3710, 1999.
  4. Williams-Bouyer N, Reisner BS and Woods GL. Comparison of Gen-Probe AccuProbe group B streptococcus culture identification test with conventional culture for the detection of group B streptococci in broth cultures of vaginal-anorectal specimens from pregnant women. Diagnostic Microbiology and Infectious Disease 36:159-162, 2000.
  5. Williams-Bouyer N, Yorke R, Lee HI and Woods GL. Comparison of the MGIT 960 and ESP Culture System II for growth and detection of mycobacteria. Journal of Clinical Microbiology. 38: 4167-4170, 2000.
  6. Woods GL, Bergmann JS, and Williams-Bouyer N. Clinical evaluation of the Gen-Probe Amplified Mycobacterium Tuberculosis Direct Test for rapid detection of M. tuberculosis in select nonrespiratory specimens. Journal of Clinical Microbiology. 39: 747-749, 2001.
  7. El Sahly HM, Septimus E, Soini H, Septimus J, Wallace RJ, Xi P, Williams-Bouyer N, Musser JM, and Graviss EA. Mycobacterium simiae Pseudo-Outbreak Resulting from Contaminated Hospital Water Supply in Houston, Texas. Clinical Infectious Diseases. Clinical Infectious Diseases. 35: 802-807, 2002.
  8. Woods GL, Williams-Bouyer N, Wallace RJ, Brown-Elliott BA, Witebsky FG, Conville,PS, Plaunt M, Hall G, Aralar P and Inderlied C. Multisite Reproducibility of Results Obtained by Two Broth Dilution Methods for Susceptibility Testing of Mycobacterium avium Complex. Journal of Clinical Microbiology. 41: 627-631, 2003.
  9. El Sahly HM, Wright JA, Soini H, Bui TT, Williams-Bouyer N, Escalante P, Musser JM and Graviss EA. Recurrent Tuberculosis in Houston, Texas- A Population-Based Study. International Journal of Tuberculosis and Lung Disease. 8: 333-340, 2004.
  10. Conger NG, O’Connell R, Laurel V, Olivier K, Graviss EA, Williams-Bouyer N,
    Zhang Y and Wallace RJ Jr. Mycobacterium simiae Pseudo-outbreak Associated with a Hospital Water Supply. Infection Control and Hospital Epidemiology. 25: 1050-1055, 2004.
  11. Zhang Y, Yarkus MA, Graviss EA, Williams-Bouyer N, Turenne C, Kabani A and Wallace RJ Jr. Pulsed-field gel electrophoresis (PFGE) study of Mycobacterium abscessus isolates previously affected by DNA degradation. Journal of Clinical Microbiology. 42: 5582-5587, 2004.
  12. Biçmen C, Esen N, Graviss EA, Williams-Bouyer N, Ramaswamy SV, and Yulug N. Molecular characterization of Mycobacterium tuberculosis isolates from Izmir, Turkey. New Microbiology. 30 (3): 229-40, 2007.
  13. Franco DM, Aronson JF, Hawkins HK, Gallagher JJ, Mendoza L, and McGinnis MR and Williams-Bouyer N. Systemic Pythium insidiosum in a pediatric burn patient. In press in Burns 2009.

NIH Biosketch

Scott C. Weaver, PhD

Basic research on the genetics, ecology, evolution and pathogenesis of arthropod-borne viruses (arboviruses), virus-mosquito interactions, and vaccine development.
BS The College of William and Mary, Williamsburg, VA Biology and Music 1979
MS Cornell University, Ithaca, NY
Advisors: Eddie Cupp, William Scherer
Medical Entomology 1982
PhD University of California, San Diego, La Jolla, CA
Advisor: John Holland
Molecular Biology and Virology 1993
Post-Doctoral Yale University School of Medicine, New Haven, CT   1994
2009-Present John S. Dunn Distinguished Chair in Biodefense
2007-Present Leon Bromberg Professor for Excellence in Teaching
2007-2009 Edgar and Mary Frances Monteith Distinguished Professor in Viral Genetics
2007 Graduate Student Organization Award for Excellence in Teaching and Mentoring
2005-Present Council, American Society of Tropical Medicine and Hygiene
2002 Dalrymple-Young Memorial Award, American Committee on Arthropod-borne Viruses
2000 Ho Wang Lee Lecturer, American Society for Virology Annual Meeting, Ft. Collins, Colorado
2000 Fogarty Senior International Fellow

Appointments
  • John Sealy Distinguished University Chair in Human Infections and Immunity
  • Director, Institute for Human Infections and Immunity
  • Scientific Director, Galveston National Laboratory
  • Leon Bromberg Professor for Excellence in Teaching
  • Member, Sealy Center for Vaccine Development
  • Core member, Sealy Center for Structural Biology
  • Associate Member, Institute for Medical Humanities
2005-Present Council, American Society of Tropical Medicine and Hygiene (elected position).
2002-Present American Committee on Arthropod-borne Viruses: Secretary-Treasurer (elected position).
1998-2000 American Committee on Arthropod-borne Viruses: Executive Council, Chair (elected position).
1997-Present Subcommittee on the Interrelationships Among Catalogued Arboviruses (SIRACA), American Committee on Arthropod-borne Viruses.
  1. Brault AC, Powers AM, Ortiz D, Estrada-Franco JG, Navarro-Lopez R, Weaver SC. Venezuelan equine encephalitis emergence: Enhanced vector infection from a single amino acid substitution in the envelope glycoprotein. Proc Natl Acad Sci U S A 101 (31): 11344-9, 2004. PMCID: PMC509205.
  2. Deardorff E, Estrada-Franco J, Brault AC, Navarro-Lopez R, Campomanes-Cortes A, Paz-Ramirez P, Solis-Hernandez M, Ramey WN, Davis CT, Beasley DW, Tesh RB, Barrett AD, Weaver SC. Introductions of West Nile virus strains to Mexico. Emerg Infect Dis 12 (2): 314-8, 2006.
  3. Anishchenko M, Bowen RA, Paessler S, Austgen L, Greene IP, Weaver SC. Venezuelan encephalitis emergence mediated by a phylogenetically predicted viral mutation. Proc Natl Acad Sci U S A 103 (13): 4994-9, 2006. PMCID: PMC1458783.
  4. Wang E, Petrakova O, Adams AP, Aguilar PV, Kang W, Paessler S, Volk SM, Frolov I, Weaver SC. Chimeric Sindbis/eastern equine encephalitis vaccine candidates are highly attenuated and immunogenic in mice. Vaccine 25 (43): 7573-81, 2007. PMCID: PMC2094013.
  5. Smith DR, Adams AP, Kenney JL, Wang E, Weaver SC. Venezuelan equine encephalitis virus in the mosquito vector Aedes taeniorhynchus: infection initiated by a small number of susceptible epithelial cells and a population bottleneck. Virology 372 (1): 176-86, 2008. PMCID: PMC2291444.
  6. Coffey LL, Vasilakis N, Brault AC, Powers AM, Tripet F, Weaver SC. Arbovirus evolution in vivo is constrained by host alternation. Proc Natl Acad Sci USA 105 (19): 6970-5, 2008. PMCID: PMC2383930.
  7. Aguilar PV, Adams AP, Wang E, Kang W, Carrara AS, Anishchenko M, Frolov I, Weaver SC. Structural and nonstructural protein genome regions of eastern equine encephalitis virus are determinants of interferon sensitivity and murine virulence. J Virol 82 (10): 4920-30, 2008. PMCID: PMC2346730.
  8. Wang E, Volkova E, Adams AP, Forrester N, Xiao SY, Frolov I, Weaver SC. Chimeric alphavirus vaccine candidates for chikungunya. Vaccine 26 (39): 5030-5039, 2008. PMCID: PMC2571998.
  9. Adams AP, Aronson JF, Tardif SD, Patterson JL, Brasky KM, Geiger R, de la Garza M, Carrion R, Jr., Weaver SC. Common marmosets (Callithrix jacchus) as a nonhuman primate model to assess the virulence of eastern equine encephalitis virus strains. J Virol 82 (18): 9035-42, 2008. PMCID: PMC2546911.
  10. Quiroz E, Aguilar PV, Cisneros J, Tesh RB, Weaver SC. Venezuelan equine encephalitis in panama: fatal endemic disease and genetic diversity of etiologic viral strains. PLoS Negl Trop Dis 3 (6): e472, 2009. PMCID: PMC2697379.
  11. Vasilakis N, Deardorff ER, Kenney JL, Rossi SL, Hanley KA, Weaver SC. Mosquitoes put the brake on arbovirus evolution: experimental evolution reveals slower mutation accumulation in mosquito than vertebrate cells. PLoS Pathog 5 (6): e1000467, 2009. PMCID: PMC2685980.
  12. Arrigo NC, Adams AP, Weaver SC. Evolutionary patterns of eastern equine encephalitis virus in North versus South America suggest ecological differences and taxonomic revision. J Virol 84 (2): 1014-25, 2010. PMCID: PMC2798374.
  13. Deardorff ER, Forrester NL, Travassos da Rosa AP, Estrada-Franco JG, Navarro-Lopez R, Tesh RB, Weaver SC. Experimental Infections of Oryzomys couesi with Sympatric Arboviruses from Mexico. Am J Trop Med Hyg 82 (2): 350-3, 2010. PMCID: PMC2813180.
  14. Volk SM, Chen R, Tsetsarkin KA, Adams AP, Garcia TI, Sall AA, Nasar F, Schuh AJ, Holmes EC, Higgs S, Maharaj PD, Brault AC, Weaver SC. Genome-scale phylogenetic analyses of chikungunya virus reveal independent emergences of recent epidemics and various evolutionary rates. J Virol 84 (13): 6497-504, 2010. PMCID: PMC2903258.
  15. Auguste AJ, Lemey P, Pybus OG, Suchard MA, Salas RA, Adesiyun AA, Barrett AD, Tesh RB, Weaver SC, Carrington CV. Yellow fever virus maintenance in Trinidad and its dispersal throughout the Americas. J Virol. Online, 2010. PMCID: PMC2937779.
  16. Deardorff ER, Weaver SC. Vector competence of Culex (Melanoconion) taeniopus for equine-virulent subtype IE strains of Venezuelan equine encephalitis virus. Am J Trop Med Hyg 82 (6): 1047-52. PMCID: PMC2877410.
  17. Sherman MB, Weaver SC. The Structure of the Recombinant Alphavirus, Western Equine Encephalitis Virus, Revealed by Cryoelectron Microscopy. J Virol. Online, 2010. PMCID: PMC2937749.
  18. Arrigo NC, Adams AP, Watts DM, Newman PC, Weaver SC. Cotton rats and house sparrows as hosts for North and South American strains of eastern equine encephalitis virus. Emerg Infect Dis 16 (9): 1373-80, 2010. PMCID: not yet available.
  19. Kenney JL, Volk SM, Pandya J, Wang E, Liang X, Weaver SC. Stability of RNA virus attenuation approaches. Vaccine, 2010. PMCID: not yet available.
  20. Tsetsarkin KA, Chen R, Leal G, Forrester N, Higgs S, Huang J, Weaver SC. Chikungunya Virus Emergence is Constrained in Asia by Lineage-Specific Adaptive Landscapes. Proc. Natl. Acad. Sci. U.S.A.: in press, 2011.

NIH Biosketch

Tian Wang, PhD

My research focuses on understanding of immune response to West Nile virus infection in protection and pathogenesis. West Nile virus, a vector-borne pathogen, has resulted in annual outbreaks of viral encephalitis in North America since 1999. Using a murine infection model, my current work explores immune factors contributing to the development of long-lasting protective immunity against West Nile virus. Aging is a known risk factor for West Nile virus induced encephalitis. The decline in immunity seen in the elderly is one of the significant contributors to the increased risk of infection. My lab also studies whether the dysfunction of immune factors in aged mice leads to a defective adaptive immunity.
BS Anhui University, P.R.China Microbiology 1992
PhD University of Texas Medical Branch, Galveston Immunology 2000
Post-Doctoral Yale University, School of Medicine Infectious Disease 2004
1997-2000 James W. McLaughlin Predoctoral Fellowship, UTMB
1999 Christina Fleischmann Scholarship Award, UTMB
2001, 2003 Kempner Postdoctoral Fellowship, UTMB
2002-2003 Postdoctoral Fellowship in Rheumatology, Yale University
2005, 2006 AAI Junior Faculty Travel Award
  • American Association of Microbiology
  • Sigma Xi, a Scientific Fraternity
  • American Association of Immunologist
  • American Association of Virologist
  • American Association for the Advancement of Science
  1. Wang T, Malawista SE, Pal U, Grey M, Meek J, Akkoyunlu M, Thomas V, and Fikrig E. (2002). Superoxide anion production during Anasplasma phagocytophila infection. J.Infec. Dis. 186:274-280. PMID: 12134266
  2. Wang T, Scully E, Yin Z., Kim JH, Wang S, Yan J, Mamula M, Anderson JF, Craft J, and Fikrig E. (2003). IFN-g - producing - gd T Cells help control murine West Nile virus infection. J Immunol. 171: 2524-2531. PMID: 12928402
  3. Wong SJ, Demarest V, Boyle RH, Wang T, Ledizet M, Kar K, Kramer L, Fikrig E, and Koski R. (2004). Detection of human antibodies to West Nile virus with a microsphere immunoassay. J Clin Microbiol. 42(1): 65-72. PMCID: PMC321652
  4. Liang FT, Brown EL, Wang T, Iozzo RV, and Fikrig E. (2004). Protective niche for Borrelia burgdorferi to evade humoral immunity. Am. J. Pathol. 165(3): 977-85. PMCID: PMC1618599
  5. Wang T, Akkoyunlu M, Banerjee R, and Fikrig E. (2004). Interferon-gamma deficiency reveals that 129Sv mice are inherently more susceptible to Anaplasma phagocytophilum than C57BL/6 mice. FEMS Microbiol. 42(3): 299-305. PMID: 15477043
  6. Wang T, and Fikrig E. (2004). Immunity to West Nile virus. (Review). Curr Opin Immunol. 16(4):519-23. PMID: 15245749
  7. Pal U, Li X, Wang T, Montgomery RR, Ramamoorthi N, deSilva AM, Bao F, Yang X, Pypaert M, Pradhan D, Kantor FS, Telford S, Anderson JF and Fikrig E. (2004). TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi. Cell. 119(4): 457-68. PMID: 15537536
  8. Wang T#, Town T#, Alexopoulou L#, Anderson JF, Fikrig E, and Flavell RA. (2004). Toll-like Receptor 3 mediates West Nile Virus entry into the brain causing lethal encephalitis. (#Authors contributed equally to this work). Nat Med. 10(12):1366-1373.
  9. Bai F, Wang T, Pal U, Bao F, Gould LH, Fikrig E. (2005). Use of RNA interference to prevent lethal murine West Nile virus infection. (2005). J Infect Dis. 191(7): 1148-54.
  10. Ledizet M, Kar K, Foellmer HG, Wang T, Bushmich SL, Anderson JF, Fikrig E, Koski RA. (2005). A recombinant envelope protein vaccine against West Nile virus. Vaccine. 23(30): 3915-24. PMID: 15917113
  11. Gould LH, Sui JH, Foellmer H, Oliphant T, Wang T, Ledizet M, Murakami A, Noonan K, Lambeth C, Kar K, Anderson JF, de Silva AM, Diamond MS, Koski RA, Marasco WA, and Fikrig E. (2005). Protective and therapeutic capacity of human single chain Fv-Fc fusion proteins against West Nile virus. J. Virol 79(23): 14606-13.
  12. Shrestha B, Wang T, Whitby K, Samuel MA, Craft J, Fikrig E, and Diamond MS. (2006). IFN-g plays a crucial early antiviral role in the protection against West Nile Virus Infection. J Virol. 80(11): 5338-48. PMCID: PMC1472130
  13. Wang T, Gao Y, Scully E, Davis CT, Anderson JF, Welte T, Ledizet M, Koski R, Madri JA, Barrett A, Yin, Craft J, and Fikrig E*. (2006). gd T cells facilitate adaptive immunity against West Nile Virus infection in mice. J. Immunol. 177(3):1825-32. PMID: 16849493
  14. Shi XR, Leng L, Wang T, Wang WK, Du X, Li J, McDonald C, Chen Z, Murphy J, Lolis E, Noble P, Knudson W and Bucala R. (2006). CD44 is the signaling component of the MIF-CD74 receptor complex. Immunity. 25(4):595-606.
  15. Arjona A, Foellmer HG, Town T, Leng L, McDonald C, Wang T, Wong SJ, Montgomery RR, Fikrig E, and Bucala R. (2007). Abrogation of macrophage migration inhibitory factor decreases West Nile virus  lethality by limiting viral neuroinvasion. J. Clin. Inv. 117: 3059-3066 PMCID: PMC1994625
  16. Welte T, Lamb J, Anderson JF, Born WK, O’Brien RL, and Wang T. (2008). The Role of Two Distinct Gamma/delta T cell Subsets during West Nile virus Infection. FEMS Immunol Med Microbiol. 53(2):275-83. PMID: 18513355
  17. Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick S, and Wang T. (2008). Drak2-mediated T cell Responses in West Nile Encephalitis. J Immunol. 181(3):2084-91.
  18. Town T, Bai F, Wang T, Kaplan AT, Qian F, Anderson JF, Flavell RA, and Fikrig E. (2009). Tlr7 mitigates lethal West Nile encephalitis by affecting interleukin 23-dependent immune cell infiltration homing. Immunity. 20:30(2):242-253. PMID: 19200759
  19. Wang S, Welte T, Fang H, Chang G, Born WK, O’Brien RL, Fujii H, Sun B, Kosuna KI, and Wang T. (2009). Active Hexose Correlated Compound Enhances Host Resistance to West Nile Encephalitis in Mice. J Nutr. 139(3):598-602. PMCID: PMC2646222
  20. Welte T, Reagan K, Fang H, Machain-Williams C, Zheng X, Mendell N, Chang GJ, Wu P, Blair CD and Wang T. (2009). Toll-like Receptor 7 Induced Immune Response to Cutaneous West Nile Virus Infection. J Gen Virol. (In press)

NIH Biosketch

Gangduo Wang, MD, PhD

Experimental models and mechanisms of chemical-induced autoimmunity.
MD Shandong Medical University, Jinan, ChinaMedicine
PhD Chinese Academy of Preventive Medicine, Beijing, China
Department of Pathology, University of Texas Medical Branch, Galveston, Texas
  1. Wang G, Pierangeli S, Papalardo E, Ansari GAS, Khan MF. Markers of Oxidative and Nitrosative Stress in Systemic Lupus Erythematosus: Correlation with Disease Activity. Arthritis Rheum (submitted) 2009.
  2. Wang G, Reed E, Cuff CF, and Li QQ. An evaluation of ß-elemene in combination with cisplatin as a regimen for prostate cancer chemotherapy. Oncol Rep (submitted) 2009.
  3. Wang G, Wang J, Ma H, Ansari GA, Khan MF.Increased Nitration and Carbonylation of Proteins in Trichloroethene-Mediated Autoimmune Response. Toxicol Appl Pharmacol. 237:188-195, 2009.
  4. Li QQ, Wang G, Zhang M, Cuff CF, Huang L, Reed E. beta-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis. Oncol Rep. 22: 161-170, 2009.
  5. Wang G, König R, Ansari GA, Khan MF. Lipid peroxidation-derived aldehyde-protein adducts contribute to trichloroethene-mediated autoimmunity via activation of CD4 (+) T cells. Free Radic Biol Med. 44:1475-1482, 2008
  6. Wang J, Wang G, Ansari GA, Khan MF. Activation of oxidative stress-responsive signaling pathways in early splenotoxic response of aniline. Toxicol Appl Pharmacol. 230: 227-234, 2008
  7. Wang G, Ansari GA, Khan MF. Involvement of lipid peroxidation-derived aldehyde-protein adducts in autoimmunity mediated by trichloroethene. J Toxicol Environ Health A. 70:1977-1985, 2007.
  8. Wang G, Cai P, Ansari GA, Khan MF. Oxidative and nitrosative stress in trichloroethene-mediated autoimmune response. Toxicology. 229:186-193, 2007.
  9. Yin XJ, Wang G, Khan-Dawood FS. Requirements of phosphatidylinositol-3 kinase and mammalian target of rapamycin for estrogen-induced proliferation in uterine leiomyoma- and myometrium-derived cell lines. Am J Obstet Gynecol. 196:176.e1-5, 2007.
  10. Zhao J, Li QQ, Wang G, Li X, Kim JE, Cuff CF, Huang L, Reed E, Gardner K. In vitro combination characterization of the new anticancer plant drug beta-elemene with taxanes against human lung carcinoma. Int J Oncol. 31:241-252, 2007.
  11. Wang G, Li X, Huang F, Zhao J, Ding H, Cunningham C, Coad J, Reed E and Li QQ. Antitumor Effect of ß-Elemene in Non Small Cell Lung Cancer Cells is Mediated via Induction of Cell Cycle Arrest and Apoptotic Cell Death. Cell Mol Life Sci. 62:881-93, 2005
  12. Li X, Wang G, Zhao J, Ding H, Cunningham C, Coad J, Reed E and Li QQ. Antiproliferative effect of ß-elemene in chemoresistant ovarian carcinoma cells is mediated through arresting the cell cycle at G2-M phase. Cell Mol Life Sci. 62: 894-904, 2005
  13. Li L, Luan Y, Li X, Tang B, Li D, Zhao J, Wang G, Ding H, Reed E, Li QQ. Demonstration of differential gene expression between sensitive and resistant ovarian tumor cells by fluorescence differential display-PCR analysis. Oncol Rep. 13: 793-799, 2005
  14. Hu J, Liu S, Wang J, Xia X, Feng Y, Tao D, Wang G, Li X, Zhao J, Ding H, Reed E, Li QQ, Gong J. Overexpression of the N-terminal end of the p55gamma regulatory subunit of phosphatidylinositol 3-kinase blocks cell cycle progression in gastric carcinoma cells. Int J Oncol. 26: 1321-1327, 2005
  15. Wang G, Reed E, Li QQ. Molecular basis of cellular response to cisplatin chemotherapy in non-small cell lung cancer. Oncol Rep. 12: 955-965, 2004
  16. Wang G, Reed E, Li QQ. Apoptosis in prostate cancer: Progressive and therapeutic implications. Int J Mol Med. 14: 23-34, 2004
  17. Han S, Zhang X, Wang G, Guan H, Garcia G, Li P, Feng L, Zheng B. FTY720 Suppresses Humoral Immunity by Inhibiting Germinal Center Reaction. Blood; 104: 4129-4133, 2004
  18. Hu G, Ryan S, Zhu Y, Reed E, Li X, Wang G, and Li QQ. Vascular endothelial growth factor modulates cisplatin sensitivity in human ovarian carcinoma cells. Cancer The. 1: 31-37, 2004
  19. Zhong X, Li X, Wang G, Zhu Y, Hu G,Zhao J, Ding H, Reed E, Li QQ.Mechanisms Underlying the Synergistic Effect of SU5416 and Cisplatin on Cytotoxicity in Human Ovarian Tumor Cells. Int J Oncol. 25: 445-451, 2004
  20. Li L, Luan Y, Wang G, Li D, Zhang W, Tang B, Reed E, Li QQ. Development and characterization of five cell models for chemoresistance studies of human ovarian carcinoma. Int J Mol Med. 14: 257-264, 2004