Benjamin B. Gelman, MD, PhD

Benjamin B. Gelman, MD, PhD

Department of Pathology
Professor, Department of Neuroscience and Cell Biology
Director, Texas NeuroAIDS Research Center
Investigator, Center for AIDS Research (CFAR), Baylor College of Medicine, Houston, TX

Phone: (409) 772-5316

Benjamin B. Gelman, MD, PhD

  • We are interested in how persistent inflammation in the brain influences neurocognitive function in people with HIV/AIDS. Our current emphasis is on its effect on synaptic protein turnover and dopaminergic synaptic transmission. We are a national resource for HIV/AIDS neuropathology and a founding center of the National NeuroAIDS Tissue Consortium. We also participate in the CHARTER study, which is a multi-site cross-sectional and longitudinal study of dementia in HIV-infected people.
  • AB Ohio University, Athens, Ohio Biochemistry 1971
    PhD University Cincinnati, Cincinnati, Ohio Environmental Health 1978
    Post-Doctoral University Cincinnati, Cincinnati, Ohio Biochemistry 1979
    MD University Cincinnati, Cincinnati, Ohio Medicine 1983
  • 2006 First Honorable Mention for the Moore Award. Senior author on the best clinicopathological presentation. American Association of Neuropathologists and World Congress of Neuropathology, San Francisco, CA, September 11.
    2006 Researcher of the Year, 12th Annual Department of Pathology Research Day
    • Member, past and present chairman, Steering Committee, National NeuroAIDS Tissue Consortium, NIH.
    • Editorial Board, Journal of Neuropathology and Experimental Neurology (term 1999-2004, 2009-2014).
    • NIH study sections regular member NAED (terms 2001 - 2006, 2008 - 2012).
    • Panelist, Alzheimer’s Association Grants Program.
    • Numerous ad hoc NIH review panels
    1. GELMAN BB, Michaelson IA, Bornschein RL. Brain lipofuscin concentration and oxidant defense enzymes in lead poisoned neonatal rats. J Toxicol Environ Health 5:683-698, 1979.
    2. GELMAN BB, Papa L, Davis MH, and Gruenstein E. Decreased lysosomal dipeptidyl aminopeptidase-I activity in cultured human skin fibroblasts in Duchenne's muscular dystrophy. J Clin Invest 65:1298-1406, 1980.
    3. GELMAN BB, Davis MH, Morris RE, and Gruenstein E. Structural changes in lysosomes from cultured human fibroblasts in Duchenne's muscular dystrophy. J Cell Biol 88:329-337, 1981.
    4. GELMAN BB, Goodrum JF, and Bouldin TW. Macrophage apolipoprotein synthesis and endoneurial distribution as a response to segmental demyelination. J Neuropathol Exp Neurol 50:383-407, 1991.
    5. Fan X and GELMAN BB. Schwann cell nerve growth factor receptor expression during initiation of remyelination. J Neuroscience Res 31:58-67, 1992.
    6. GELMAN BB, Rodriguez MG, Wen J, Campbell GA, Herzog N. Siderotic cerebral macrophages in the acquired immunodeficiency syndrome. Arch Pathol Lab Med 116:509-516, 1992.
    7. GELMAN BB and Guinto FC Jr. Morphometry, histopathology, and tomography of cerebral atrophy in the acquired immunodeficiency syndrome. Ann Neurol 32:32-40, 1992.
    8. GELMAN BB. Diffuse microgliosis associated with cerebral atrophy in the acquired immunodeficiency syndrome. Ann Neurol 34:65-70, 1993.
    9. GELMAN BB. Iron in CNS disease. J Neuropathol Exp Neurol 54:477-486, 1995.
    10. Jaffey PB, GELMAN BB. Increased vulnerability to demyelination in streptozotocin diabetic rats. J Comp Neurol 373:55-61, 1996.
    11. DiPatre PL, GELMAN BB. Microglial cell activation in aging and Alzheimer's disease: partial correlation with neurofibrillary tangle burden. J Neuropathol Exp Neurol 56:137-143, 1997.
    12. Wolf DA, Dholakia S, Cloyd MW, GELMAN BB. Proteolysis in the myelopathy of acquired immunodeficiency syndrome: preferential loss of the C-8 component of myelin basic protein. Lab Invest 77(5):513-523, 1997.
    13. GELMAN BB, Wolf DA, Rodriguez-Wolf M, West B, Haque A, Cloyd MW. Mononuclear phagocyte hydrolytic enzyme activity associated with cerebral HIV infection. Am J Pathol 151:1437-1446, 1997.
    14. GELMAN BB, Nader R, Popov V, Borkowski J, Rauf S, Chaljub G, Visvesvara, Nauta H. Encephalitis due to Sappinia diploidea. JAMA 285:2450-2451, 2001.
    15. GELMAN BB, Popov V, Chaljub G, Nader R, Rauf S, Nauta H, and Visvesvara GS. Neuropathology and ultrastructural features of encephalitis due to Sappinia diploidea. J Neuropathol Exp Neurol 62:990-998, 2003.
    16. GELMAN BB, Schuenke KW. Brain aging in AIDS: Increased ubiquitin-protein conjugate and correlation with decreased synaptic protein but not Ab-stained diffuse plaque. J Neurovirol. 10:98-108, 2004.
    17. GELMAN BB, Soukup VM, Holzer CE III, Fabian RH, Schuenke KW, Keherly MJ, Richey FJ. Lysosome Expansion in White Matter: Potential Correlate of Altered Membrane Turnover in HIV-associated Dementia. J AIDS 39:422-425, 2005.
    18. GELMAN BB, Spencer JA, Holzer CE III, Soukup VM. Abnormal striatal dopaminergic synapses in National NeuroAIDS Tissue Consortium subjects with HIV encephalitis. J Neuroimmune Pharmacol 1:410-420, 2006.
    19. Qvarnstrom Y, da Silva AJ, Schusster FL, GELMAN BB, Visvesvara G. Molecular confirmation of Sappinia pedata as a causative agent of amoebic encephalitis. J Infect Dis 199:1139-1142, 2009.
    20. Nguyen TN, Soukup VM, GELMAN BB. Persistent "hijacking" of brain proteasomes in HIV-associated dementia. Am J Pathol. In press.

    NIH Biosketch