Hal K. Hawkins, MD, PhD

Hal K. Hawkins, MD, PhD

Department of Pathology
Professor, Department of Pediatrics
Member, Graduate School of Biomedical Sciences
Co-Director, Morphology and Pathology Laboratory, Shriners Burns Hospital
Medical Director, Electron Microscopy Laboratory

Phone: (409) 770-6635
Email: hhawkins@utmb.edu

Hal K. Hawkins, MD, PhD

    1. Areas of research:
      My major research interests are in the inflammatory and reparative reactions to tissue injury. Current work is directed at elucidating the mechanisms involved in the responses of the respiratory tract to inhalation of toxic smoke, especially those involving CGRP and other neuropeptides and nitric oxide.
    2. Currently funded grant support:
      I serve as co-director and P.I. of the pathology and morphology core facility of the Shriners Hospitals for Children, Galveston Unit, which functions primarily to provide support to multiple investigators involved in basic and applied burn research and to develop new projects and improved methodology for studies of injured tissues. Shriners Hospitals for Children funds this lab for calendar year 2009 with direct costs of $148,134.
    3. I serve as co-investigator on an NIH grant, George Saade, PI, as one of five participating centers involved in the Stillbirth Collaborative Research Network, with 5% effort
  •   Rice University, Houston, Texas Biochemistry 1966
    PhD Duke University, Durham, North Carolina Experimental Pathology 1971
    MD Duke University, Durham, North Carolina Medicine 1972
    Residency Duke University, Durham, North Carolina Anatomic Pathology 1975
    Fellowship University of Florida, Florida Developmental and Pediatric Pathology 1983
  • 1962 Fleming Scholarship, Oklahoma Medical Research Foundation
    1966 Full scholarship, Duke University Medical School
    1968 Medical Scientists Training Program scholarship
  • National:
    2008-Present Membership Committee, Society for Pediatric Pathology
    2008-Present Research Committee, American Burns Association
    1994-2008 Shriners Burns Hospital, Scientific Ethics Committee
    1996-2008 Shriners Burns Hospital, Medical Executive Committee
    2000-2008 Shriners Burns Hospital, Credentials Committee, Chair
    2006-Present (Chair 2009) UTMB School of Medicine APT Committee
    2006-2008 Laser Scanning Confocal Microscopy Core Facility Advisory Board
    2007-Present Advisory Board, UTMB Academy of Master Teachers
    1. Traber DL, Hawkins HK, Enkhbaatar P, Cox RA, Schmalstieg FC, Zwischenberger JB, Traber LD. The role of the bronchial circulation in the acute lung injury resulting from burn and smoke inhalation. Pulm Pharmacol Ther 20:163-6, 2007.
    2. Maybauer MO, Maybauer DM, Fraser JF, Traber LD, Westphal M, Enkhbaatar P, Cox RA, Huda R, Hawkins HK, Morita N, Murakami K, Mizutani A, Herndon DN, Traber DL. Recombinant human activated protein C improves pulmonary function in ovine acute lung injury resulting from smoke inhalation and sepsis. Crit Care Med 34:2432-8, 2006.
    3. Cox RA, Burke AS, Traber DL, Herndon DN, Hawkins HK. Production of pro-inflammatory polypeptides by airway mucous glands and its potential significance. Pulm Pharmacol Ther 20:172-7, 2007.
    4. Baregamian N, Rychahou PG, Hawkins HK, Evers BM, Chung DH. Phosphatidylinositol 3-kinase pathway regulates hypoxia-inducible factor-1 to protect from intestinal injury during necrotizing enterocolitis. Surgery 142:295-302, 2007.
    5. Schmalstieg FC, Keeney SE, Rudloff HE, Palkowetz KH, Cevallos M, Zhou X, Cox RA, Hawkins HK, Traber DL, Zwischenberger JB. Arteriovenous CO2 removal improves survival compared to high frequency percussive and low tidal volume ventilation in a smoke/burn sheep acute respiratory distress syndrome model. Ann Surg 246:512-23, 2007.
    6. Gore DC, Hawkins HK, Chinkes DL, Chung DH, Sanford AP, Herndon DN, Wolf SE. Assessment of adverse events in the demise of pediatric burn patients. J Trauma 63:814-8, 2007.
    7. Ragouilliaux CJ, Keeney SE, Hawkins HK, Rowen JL. Maternal factors in extremely low birth weight infants who develop spontaneous intestinal perforation. Pediatrics 120:e1458-64, 2007.
    8. Murakami K, Enkhbaatar P, Yu YM, Traber LD, Cox RA, Hawkins HK, Tompkins RG, Herndon D, Traber DL. L-arginine attenuates acute lung injury after smoke inhalation and burn injury in sheep. Shock 28:477-83, 2007.
    9. Cox RA, Mlcak RP, Chinkes DL, Jacob S, Enkhbaatar P, Jaso J, Parish LP, Traber DL, Jeschke MG, Herndon DN, Hawkins HK. Upper airway mucus deposition in lung tissue of burn trauma victims. Shock 29:356-61, 2008.
    10. Hamahata A, Enkhbaatar P, Kraft ER, Lange M, Leonard SW, Traber MG, Cox RA, Schmalstieg FC, Hawkins HK, Whorton EB, Horvath EM, Szabo C, Traber LD, Herndon DN, Traber DL. Gamma-tocopherol nebulization by a lipid aerosolization device improves pulmonary function in sheep with burn and smoke inhalation injury. Free Radic Biol Med 45:425-33, 2008.
    11. Mizutani A, Enkhbaatar P, Esechie A, Traber LD, Cox RA, Hawkins HK, Deyo DJ, Murakami K, Noguchi T, Traber DL. Pulmonary changes in a mouse model of combined burn and smoke inhalation-induced injury. J Appl Physiol 105:678-84, 2008.
    12. Murphy KD, Mushkudiani IA, Kao D, Levesque AY, Hawkins HK, Gould LJ. Successful incorporation of tissue-engineered porcine small-intestinal submucosa as substitute flexor tendon graft is mediated by elevated TGF-beta-1 expression in the rabbit. J Hand Surg 33:1168-78, 2008.
    13. Jacob S, Deyo DJ, Cox RA, Traber DL, Hawkins HK. Assessment of lung inflammation in a mouse model of smoke inhalation and burn injury: Strain-specific differences. Toxicol Mech Methods 18:551-9, 2008.
    14. Westphal M, Enkhbaatar P, Schmalstieg FC, Kulp GA, Traber LD, Morita N, Cox RA, Hawkins HK, Westphal-Varghese BB, Rudloff HE, Maybauer DM, Maybauer MO, Burke AS, Murakami K, Saunders F, Horvath EM, Szabo C, Traber DL. Neuronal nitric oxide synthase inhibition attenuates cardiopulmonary dysfunctions after combined burn and smoke inhalation injury in sheep. Crit Care Med 36:1196-204, 2008.
    15. Esechie A, Kiss L, Olah G, Horvath EM, Hawkins H, Szabo C, Traber DL. Protective effect of hydrogen sulfide in a murine model of acute lung injury induced by combined burn and smoke inhalation. Clin Sci 115:91-7, 2008.
    16. Lange M, Connelly R, Traber DL, Hamahata A, Cox RA, Nakano Y, Bansal K, Esechie A, von Borzyskowski S, Jonkam C, Traber LD, Hawkins HK, Herndon DN, Enkhbaatar P. Combined neuronal and inducible nitric oxide synthase inhibition in ovine acute lung injury. Crit Care Med 37:223-9, 2009.
    17. Cox RA, Jacob S, Oliveras G, Murakami K, Enkhbaatar P, Traber L, Schmalstieg FC, Herndon DN, Traber DL, Hawkins HK. Pulmonary expression of nitric oxide synthase isoforms in sheep with smoke inhalation and burn injury. Exp Lung Res 35:104-18, 2009.
    18. Cox RA, Burke AS, Jacob S, Oliveras G, Murakami K, Shimoda K, Enkhbaatar P, Traber LD, Herndon DN, Traber DL, Hawkins HK., Activated nuclear factor kappa B and airway inflammation after smoke inhalation and burn injury in sheep. J Burn Care Res 30:489-98, 2009.
    19. Jacob S, Deyo DJ, Cox RA, Traber DL, Hawkins HK. Mechanisms of toxic smoke inhalation and burn in jury: Role of neutral endopeptidase and vascular leakage in mice. Toxicol Mech Methods 19:191-6, 2009.
    20. Lange M, Enkhbaatar P, Traber DL, Cox RA, Jacob S, Mathew BP, Hamahata A, Traber LD, Herndon DN, Hawkins HK. Role of calcitonin gene-related peptide (CGRP) in ovine burn and smoke inhalation injury. J Appl Physiol 107:176-84, 2009.

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