Jere W. McBride, PhD

Jere W. McBride, PhD, MS
Professor

Departments of Pathology and Microbiology & Immunology
Center for Biodefense and Emerging Infectious Diseases
Director, Experimental Pathology Graduate Program
Member, Center for Biodefense and Emerging Infectious Diseases
Scientist, Sealy Institute for Vaccine Sciences
Member, Institute for Human Infections and Immunity

Phone: (409) 747-2498
Email: jemcbrid@utmb.edu
UTMB Research Experts

Jere W. McBride, PhD

  • Dr. McBride’s research program focuses on understanding molecular and cellular pathogen-host interactions involved in infection of mononuclear phagocytes and mechanisms of immunity to pathogenic obligately intracellular bacteria. His research team studies Ehrlichia spp. which are obligate intracellular bacteria with small genomes, yet they evolved sophisticated molecular mechanisms to survive in phagocytes. Dr. McBride’s group uses Ehrlichia as model system to explore interkingdom molecular interactions between prokaryotes and eukaryotes involved in infection and immune evasion. Ehrlichia spp. survive and replicate in professional phagocytes by activating and modulating evolutionarily conserved host cell signaling pathways (Wnt and Notch), and reprogramming host cell gene transcription through nucleomodulin effectors. The research focus of Dr.McBride’s laboratory is in five main areas of exploration 1) nucleomodulins and reprogramming host gene transcription, 2) exploitation of conserved host cell pathways to subvert innate host defense mechanisms, 3)  understanding the role of post translational modifications in pathogen-host interface and infection, 4) defining the molecular basis and mechanisms of humoral immunity to intracellular bacteria, and 5) development of subunit vaccines, immunodiagnostics and therapeutics for the ehrlichioses.

    Dr. McBride’s research team has defined ehrlichial type 1 effectors instrumental in a cellular reprogramming strategy, identified novel molecular effector‐host interactions with conserved host cell pathways to subvert innate host defense mechanisms, defined ehrlichial nucleomodulins that target host cell genes and reprogram host cell gene transcription, defined immunoprotective proteins/epitopes, and identified novel mechanisms of antibody-mediated immunity. In translational areas of research, Dr. McBride’s group has developed immunodiagnostics, subunit vaccines and therapeutics for the ehrlichioses. Dr. McBride is currently supported by grants from the NIH and CDC and he has active collaborations with industry partners to develop vaccines and diagnostics for ehrlichial diseases.

  • BS Louisiana State University, Baton Rouge Microbiology 1987
    MS Louisiana State University, Baton Rouge Microbiology/Immunology 1993
    PhD University of California, Davis Comparative Pathology 1997
    Fellowship University of Texas Medical Branch Cellular Microbiology 1999
  • 1999 James W. McLaughlin Award for Research Excellence in Infection and Immunity, University of Texas Medical Branch
    1999 Postdoctoral Award for Molecular/ Cell Biology Research, Department of Pathology, Pathology Trainee Research Session University of Texas Medical Branch
    2004 Experimental Pathology Graduate Student Award for Teaching and Mentoring, University of Texas Medical Branch
    2004 Department of Pathology nominee for the W.M. Keck Foundation Distinguished Young Scholars in Medical Research Award
    2009 Department of Pathology, Researcher of the Year
    2017-Present Editorial Board, Infection and Immunity
    • American Society for Microbiology
    • American Society for Investigative Pathology
    • American Society for Rickettsiology
    • American Society for Cell Biology (ASCB)
    1. Luo T, Patel J, Zhang XF, Walker DH and McBride JW. Ehrlichia chaffeensis and E. canis hypothetical protein immunoanalysis reveals small secreted immunodominant proteins and conformation-dependent antibody epitopes. npj Vaccines 2020. 85: doi: doi:/10.1038/s41541-020-00231-1 PMCID: PMC7486380.
    2. Wang JY, Zhu B, Patterson LL, Kibler CE, McBride JW. Ehrlichia chaffeensis TRP120-mediated ubiquitination and proteasomal degradation of tumor suppressor FBW7 increases oncoprotein stability and promotes infection. PLoS Pathogens,2020. Apr 30;16(4):e1008541. doi: 10.1371/journal.ppat.1008541. PMCID: PMC7217479
    3. Rumfield C, Hyseni I, McBride JW, Walker DH, Fang R. Activation of ASC inflammasome driven by TLR4 contributes to host immunity against rickettsial infection. Infect. Immun. 2020. Jan 7:101367. doi: 10.1016/j.ttbdis.2019.101367 PMCID: PMC7093143
    4. Velayutham TS, Kumar S, Zhang XF, Kose N, Walker DH, Winslow G, Crowe JE, and McBride JW. Ehrlichia chaffeensis outer membrane protein 1-specific  human antibody-mediated immunity is defined by intracellular TRIM21-dependent innate immune activation and extracellular neutralization. Infect. Immun. 2019 87:e00383-19.  PMCID: PMC6867850. (Selected by the editors as an article of significant interest-“Spotlight”)
    5. Kibler CE, Milligan SL, Farris TR, Zhu B, Mitra S and McBride JW. Ehrlichia chaffeensis TRP47 enters the nucleus via a MYND-binding domain-dependent mechanism and predominately binds enhancers of host genes associated with signal transduction, cytoskeletal organization, and immune response. PloS One 2018 13:e0205983. doi: 10.1371/journal.pone.0205983. PMCID: PMC6224051.
    6. Luo T, Mitra S, and McBride JW. Ehrlichia chaffeensis TRP75 interacts with host cell targets involved in homeostasis, cytoskeleton organization, and apoptosis regulation to promote infection.  mSphere. 2018 11;3. pii: e00147-18. doi: 10.1128/mSphere.00147-18. PMCID: PMC59059120
    7. Klema VJ, Sepuru KM, Fullbrunn N, Farris TR, Dunphy PS, McBride JW, Rajarathnam K, Choi KH. Ehrlichia chaffeensis TRP120 nucleomodulin binds DNA with disordered tandem repeat domain. PloS One 2018 Apr 11;13(4):e0194891. doi: 10.1371/journal.pone.0194891. PMCID: PMC5895000.
    8. Mitra S, Dunphy PS, Das S, Zhu B, Luo T, McBride JW. Ehrlichia chaffeensis TRP120 effector targets and recruits host polycomb group proteins for degradation to promote intracellular infection.  Infect. Immun. 2018;86:e00845-17.  PMCID: PMC5865042
    9. Farris TR, Zhu B, Wang JY, McBride JW. Ehrlichia chaffeensis TRP32 nucleomodulin function and localization is regulated by NEDD4L-mediated ubiquitination. Front. Cell. Infect. Microbiol. 2018,7: Jan 11;7:534. doi: 10.3389/fcimb.2017.00534. PMCID: PMC5768648
    10. Lina T, Lou T, Velayutham T, McBride JW. Ehrlichia activation of Wnt-PI3K-mTOR signaling inhibits autolysosome generation and autophagic destruction by the mononuclear phagocyte. Infect. Immun. 2017 Oct 9. pii: IAI.00690-17. doi: 10.1128/IAI.00690-17. PMID 28993455.
    11. Lina TT, Dunphy PS, Luo T, McBride JW.  Ehrlichia chaffeensis TRP120 activates canonical Notch signaling to downregulate TLR2/4 expression and promote intracellular survival. mBio 2016; 7: e00672-16 PMCID: PMC4958247
    12. Dunphy PS, Luo T, and McBride JW.  Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival.  Infect. Immun.  2014; 82:4154-68.  PMCID: PMC4187855 (Selected by the editors as an article of significant interest-“Spotlight” p.3989).
    13. Luo T, Dunphy PS, Lina TT, McBride JWEhrlichia chaffeensis exploits canonical and noncanonical host Wnt signaling pathways to stimulate phagocytosis and promote intracellular survival.  Infect. Immun. 2016; 84:686-700. PMCID: PMC4771358 (Selected by the editors as an article of significant interest-“Spotlight” p.611).
    14. Zhu B, Nethery KA, Kuriakose JA, Zhang, XF, and McBride JW.  Nuclear translocated Ehrlichia chaffeensis ankyrin repeat protein interacts with the mid-A stretch of host promoter and intronic Alu elements.  Infect Immun 2009; 77:4243-4255. (Selected by the editors as an article of significant interest-“Spotlight” p.4181) PMCID: 2747939
    15. Zhu B, Kuriakose JA, Luo T, Ballesteros E, Gupta S, Fofanov Y, and McBride JWEhrlichia chaffeensis TRP120 bind a G+C-rich motif in host cell DNA and exhibits eukaryotic transcriptional activator function.  Infect. Immun. 2011; 79:4370-4381. PMCID: 3257946
    16. Mitra S, Dunphy PS, Das S, Zhu B, Luo T, McBride JW. Ehrlichia chaffeensis TRP120 effector targets and recruits host polycomb group proteins for degradation to promote intracellular infection.  Infect. Immun. 86:e00845-17. PMID 29358333.
    17. Farris TR, Dunphy PS, Zhu B, Kibler CE, and McBride JW. Ehrlichia chaffeensis TRP32 is a nucleomodulin that directly regulates expression of host genes governing differentiation and proliferation.  Infect. Immun.  2016; 84: 3182-3194. Aug 29. pii: IAI.00657-16 (Selected by the editors as an article of significant interest-“Spotlight” p.3093).  PMCID: PMC 5067751.
    18. Luo T, Zhang XF, Wakeel A, Popov VL, and McBride JW.  Variable-length PCR target protein of Ehrlichia chaffeensis contains major species-specific antibody epitopes in highly acidic serine-rich tandem repeats. Infect. Immun.  2008; 76:1572-1580. PMCID: 2292866
    19. McBride JW, Zhang XF, Wakeel A, and Kuriakose J. Tyrosine phosphorylated Ehrlichia chaffeensis and E. canis tandem repeat orthologs contain a major continuous cross-reactive antibody epitope in lysine-rich repeats. Infect. Immun. 2011; 79:3178-3187. PMCID: 3147547
    20. Kuriakose J, Zhang XF, Luo T and McBride JW.  Molecular basis of antibody mediated immunity to Ehrlichia chaffeensis involves species-specific linear epitopes in tandem repeat proteins. Microbes Infect. 2012; 14:1054-63. PMCID: 3445803
    21. McBride JW and Walker DH.  2010.  Progress and Obstacles in Vaccine Development for the Ehrlichioses. Expert Reviews of Vaccines. Review. 9:1071-1082. PMCID: 2951016
    22. Zhu B, Das S, Mitra S, Farris TR, McBride JW. Ehrlichia chaffeensis TRP120 moonlights as a HECT E3 Ligase involved in self- and host ubiquitination to influence protein interactions and stability for intracellular survival.  Infect. Immun. 2017 85:1-16 pii: e00290-17. doi: 10.1128/IAI.00290-17  PMID 28630068.
    23. Wakeel A, Kuriakose J, and McBride JW.  An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation and vesicle trafficking. Infect. Immun.  2009; 76:1572-1580.  (Selected by the editors as an article of significant interest-“Spotlight” p.1721) PMCID: 2681728
    24. Luo T and McBride JW.  Ehrlichia chaffeensis TRP32 interacts with host cell targets that influence intracellular survival.  Infect. Immun. 2012; 80:2297-2306.  PMCID: 3416477
    25. Luo T, Kuriakose KA, Zhu B, Wakeel A, and McBride JW.  Ehrlichia chaffeensis TRP120 interacts with a diverse array of eukaryotic proteins involved in transcriptional regulation, signaling, and cytoskeleton organization. Infect. Immun. 2011; 79:4382-4391. PMCID: 3257936
    26. Wakeel A, den Dulk-Ras A, Hooykas PJJ, McBride JW. Ehrlichia chaffeensis tandem repeat proteins are type 1 secretion system substrates related to the repeats-in-toxin exoprotein family.  Front. Cell. Infect. Microbio. 2011; 1:1-19.  PMCID: 3417381
    27. Lina T, Lou T, Velayutham T, McBride JW. Ehrlichia activation of Wnt-PI3K-mTOR signaling inhibits autolysosome generation and autophagic destruction by the mononuclear phagocyte. Infect. Immun. 2017 Oct 9. pii: IAI.00690-17. doi: 10.1128/IAI.00690-17. PMID 28993455.
    28. Lina TT, Dunphy PS, Luo T, McBride JW.  Ehrlichia chaffeensis TRP120 activates canonical Notch signaling to downregulate TLR2/4 expression and promote intracellular survival. mBio 2016; 7: e00672-16 PMCID: PMC4958247
    29. Dunphy PS, Luo T, and McBride JW.  Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival.  Infect. Immun.  2014; 82:4154-68.  PMCID: PMC4187855 (Selected by the editors as an article of significant interest-“Spotlight” p.3989).
    30. Luo T, Dunphy PS, Lina TT, McBride JWEhrlichia chaffeensis exploits canonical and noncanonical host Wnt signaling pathways to stimulate phagocytosis and promote intracellular survival.  Infect. Immun. 2016; 84:686-700. PMCID: PMC4771358 (Selected by the editors as an article of significant interest-“Spotlight” p.611).
    31. Zhu B, Nethery KA, Kuriakose JA, Zhang, XF, and McBride JW.  Nuclear translocated Ehrlichia chaffeensis ankyrin repeat protein interacts with the mid-A stretch of host promoter and intronic Alu elements.  Infect Immun 2009; 77:4243-4255. (Selected by the editors as an article of significant interest-“Spotlight” p.4181) PMCID: 2747939
    32. Zhu B, Kuriakose JA, Luo T, Ballesteros E, Gupta S, Fofanov Y, and McBride JWEhrlichia chaffeensis TRP120 bind a G+C-rich motif in host cell DNA and exhibits eukaryotic transcriptional activator function.  Infect. Immun. 2011; 79:4370-4381. PMCID: 3257946
    33. Mitra S, Dunphy PS, Das S, Zhu B, Luo T, McBride JW. Ehrlichia chaffeensis TRP120 effector targets and recruits host polycomb group proteins for degradation to promote intracellular infection.  Infect. Immun. 86:e00845-17. PMID 29358333.
    34. Farris TR, Dunphy PS, Zhu B, Kibler CE, and McBride JW. Ehrlichia chaffeensis TRP32 is a nucleomodulin that directly regulates expression of host genes governing differentiation and proliferation.  Infect. Immun.  2016; 84: 3182-3194. Aug 29. pii: IAI.00657-16 (Selected by the editors as an article of significant interest-“Spotlight” p.3093).  PMCID: PMC 5067751.
    35. Luo T, Zhang XF, Wakeel A, Popov VL, and McBride JW.  Variable-length PCR target protein of Ehrlichia chaffeensis contains major species-specific antibody epitopes in highly acidic serine-rich tandem repeats. Infect. Immun.  2008; 76:1572-1580. PMCID: 2292866
    36. McBride JW, Zhang XF, Wakeel A, and Kuriakose J. Tyrosine phosphorylated Ehrlichia chaffeensis and E. canis tandem repeat orthologs contain a major continuous cross-reactive antibody epitope in lysine-rich repeats. Infect. Immun. 2011; 79:3178-3187. PMCID: 3147547
    37. Kuriakose J, Zhang XF, Luo T and McBride JW.  Molecular basis of antibody mediated immunity to Ehrlichia chaffeensis involves species-specific linear epitopes in tandem repeat proteins. Microbes Infect. 2012; 14:1054-63. PMCID: 3445803
    38. McBride JW and Walker DH.  2010.  Progress and Obstacles in Vaccine Development for the Ehrlichioses. Expert Reviews of Vaccines. Review. 9:1071-1082. PMCID: 2951016
    39. Zhu B, Das S, Mitra S, Farris TR, McBride JW. Ehrlichia chaffeensis TRP120 moonlights as a HECT E3 Ligase involved in self- and host ubiquitination to influence protein interactions and stability for intracellular survival.  Infect. Immun. 2017 85:1-16 pii: e00290-17. doi: 10.1128/IAI.00290-17  PMID 28630068.
    40. Wakeel A, Kuriakose J, and McBride JW.  An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation and vesicle trafficking. Infect. Immun.  2009; 76:1572-1580.  (Selected by the editors as an article of significant interest-“Spotlight” p.1721) PMCID: 2681728
    41. Luo T and McBride JW.  Ehrlichia chaffeensis TRP32 interacts with host cell targets that influence intracellular survival.  Infect. Immun. 2012; 80:2297-2306.  PMCID: 3416477
    42. Luo T, Kuriakose KA, Zhu B, Wakeel A, and McBride JW.  Ehrlichia chaffeensis TRP120 interacts with a diverse array of eukaryotic proteins involved in transcriptional regulation, signaling, and cytoskeleton organization. Infect. Immun. 2011; 79:4382-4391. PMCID: 3257936
    43. Wakeel A, den Dulk-Ras A, Hooykas PJJ, McBride JW. Ehrlichia chaffeensis tandem repeat proteins are type 1 secretion system substrates related to the repeats-in-toxin exoprotein family.  Front. Cell. Infect. Microbio. 2011; 1:1-19.  PMCID: 3417381

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