Kirill A. Lyapichev, MD
Assistant Professor
(N-T Trk Clin)

Department of Pathology
Director of Hematopathology
Director of Flow Cytometry Laboratory

Email: kilyapic@utmb.edu

  • Research Interests: Hematological disorders including neoplastic as well as non-neoplastic entities: BIA-ALCL, MALT lymphoma, Castleman Disease, Kikuchi Disease, and others.

  • Clinical Fellowships

    • The University of Texas MD Anderson Cancer Center, Houston, TX, USA
      Molecular Genetic Pathology 2020 – 2021
    • The University of Texas MD Anderson Cancer Center, Houston, TX, USA
      Advance Hematopathology 2019 – 2020
      Chief Fellow 2019 – 2020
    • The University of Texas MD Anderson Cancer Center, Houston, TX, USA
      Hematopathology 2018 – 2019

    Residency

    University of Miami Miller School of Medicine/Jackson Memorial Hospital, Miami FL, USA
    Anatomic and Clinical Pathology 2014 - 2018

    Research Fellowships

    University of Miami, Department of Neurological Surgery, Miami, FL, USA 2011 – 2014

    University of Miami, Department of Microbiology & Immunology, Miami, FL, USA 2007 - 2010

    Medical Degree

    Voronezh State Medical Academy, Voronezh, Russia Medicine 2000 - 2006

    • University of Miami Research Recognition Award 2015 - 2018
    • The Dr. L. Clarke, Jr. and Elaine F. Stout Award (USCAP) 2020
    • ASCP 40 Under Forty honoree 2020
    • Hematopathology Subspecialty Certified 2020
    • Anatomical Pathology/Clinical Pathology Board Certified 2018
    • American Society of Hematology 2020 – present
    • Association of Molecular Pathology 2020 - present
    • United States and Canadian Academy of Pathology 2015 - present
    • College of American Pathologists 2015 - present
    • Florida Society of Pathologists 2014 - 2018
    • American Society for Clinical Pathology 2014 – present
    1. Lyapichev KA, Medeiros LJ, Ivashkevich Y, Thakral B, Dabaja BS, Lin P, Iqbal F, Konoplev S. MALT lymphoma of the tongue: An unusual site that may present a diagnostic challenge. Ann Diagn Pathol. 2021 Oct 23;56:151841. doi: 10.1016/j.anndiagpath.2021.151841. Epub ahead of print. PMID: 34717192.
    2. Gonzalez AC, Olobatuyi FA, Lyapichev KA. Breast Myeloid Sarcoma. eJHaem. 2021 doi: 10.1002/jha2.306
    3. Hussein S., Wang W., Wang SA, Fang H., Garces S., Tashakori M., Lyapichev KA, Qiu L., Wang X., Loghavi S., Medeiros LJ, Challagundla P., Jorgensen. JL. Hematogones with Light Chain Restriction: A Potential Diagnostic Pitfall When Using Flow Cytometry Analysis to Assess Bone Marrow Specimens, Leukemia Research, 2021, 106704, ISSN 0145-2126. https://doi.org/10.1016/j.leukres.2021.106704.
    4. Lyapichev KA, Calleroz A, Marcogliese AN. Bone marrow involvement by classic Hodgkin lymphoma posttransplant lymphoproliferative disorder. eJHaem. https://doi.org/10.1002/jha2.258
    5. Lyapichev KA, Loghavi S, El Hussein S, Al-Maghrabi H, Xu J, Konoplev S, Medeiros LJ, Khoury JD. Future of Education or Present Reality? Arch Pathol Lab Med. 2021 Nov 1;145(11):1350-1354. doi: 10.5858/arpa.2021-0195-SA. PMID: 34283888.
    6. Lyapichev KA, Ivashkevich Y, Chernov Y, Chinenov D, Shpot E, Bessonov AA, Dabaja BS, Konoplev S. MALT Lymphoma of the Urinary Bladder Shows a Dramatic Female Predominance, Uneven Geographic Distribution, and Possible Infectious Etiology. Res Rep Urol. 2021 Feb 5;13:49-62. doi: 10.2147/RRU.S283366.
    7. Lyapichev KA, Tang G, Li S, You MJ, Cheng TJ, Miranda RN, Iyer S, Yin CC, Konoplev SN, Bueso-Ramos C, Vega F, Medeiros LJ, Xu J. MYC expression is associated with older age, common morphology, increased MYC copy number, and poorer prognosis in patients with ALK+ anaplastic large cell lymphoma. Hum Pathol. 2021 Feb;108:22-31. doi: 10.1016/j.humpath.2020.11.002. Epub 2020 Nov 19. PMID: 33221344.
    8. El Hussein S, Khoury JD, Lyapichev KA, Tashakori M, Khanlari M, Miranda RN, Kanagal-Shamanna R, Wang SA, Ahmed A, Mirza KM, Crane GM, Medeiros LJ, Loghavi S. Next Generation Scholarship-Rebranding Hematopathology Using Twitter. The MD Anderson Experience. Mod Pathol. 2021 May;34(5):854-861. doi: 10.1038/s41379-020-00715-4. Epub 2020 Nov 20. PMID: 33219298; PMCID: PMC7678590.
    9. Lyapichev KA, Sukswai N, Angelova E, Kersh MJ, Pierce S, Konopleva M, Jain N, Jabbour EJ, Jorgensen JL, Wang SA, Medeiros LJ, Khoury JD, Konoplev S. CD123 Expression in Philadelphia-chromosome-Like B Acute Lymphoblastic Leukemia/Lymphoma. Clin Lymphoma Myeloma Leuk. 2021 Apr;21(4):e317-e320. doi: 10.1016/j.clml.2020.09.014. Epub 2020 Oct 8. PMID: 33129747.
    10. El Hussein S, Lyapichev KA, Crane GM, Mirza KM, Pemmaraju N, Medeiros LJ, Khoury JD, Loghavi S. Social Media for Hematopathologists: Medical Practice Reinvented-#Hemepath. Curr Hematol Malig Rep. 2020 Oct;15(5):383-390. doi: 10.1007/s11899-020-00600-6. Epub 2020 Oct 30. PMID: 33128122.
    11. Lyapichev KA, Sakhdari A, Khoury JD, O’Malley DP, El Hussein S, Yin CC, Patel KP, Thakral B, Young KH, Medeiros LJ, Konoplev S. Lymphoid Enhancer Binding Factor 1 (LEF1) Expression is Significantly Higher in Hodgkin Lymphoma Associated with Richter Syndrome Relative to de novo Classic Hodgkin Lymphoma. Ann Diagn Pathol. 2020 Dec;49:151636. doi: 10.1016/j.anndiagpath.2020.151636. Epub 2020 Sep 19. PMID: 32977233.
    12. Ivashkevich Y, Chernov Y, Chinenov D, Shpot E, Bessonov AA, Yoga A, Lyapichev KA, Konoplev S. Unusual Case of Anaplastic Large Cell Lymphoma Presenting as a Breast Mass in a Patient with no History of Breast Implants. Case Rep Pathol. 2020 Jul 23;2020:7543836. doi: 10.1155/2020/7543836. PMID: 32774970; PMCID: PMC7396074.
    13. Lyapichev KA, Bah I, Huen A, Duvic M, Routbort MJ, Wang W, Jorgensen JL, Medeiros LJ, Vega F, Craig FE, Wang SA. Determination of immunophenotypic aberrancies provides better Assessment of Peripheral Blood Involvement by Mycosis Fungoides/Sézary Syndrome than Quantification of CD26- or CD7- CD4+ T cells. Cytometry B Clin Cytom. 2021 Mar;100(2):183-191. doi: 10.1002/cyto.b.21933. Epub 2020 Jul 15. PMID: 32667737.
    14. Lyapichev KA, Jelloul FZ. Simultaneous bone marrow involvement by CLL/SLL and LEF1/cyclin D1 positive metastatic melanoma. Blood. 2020 Jul 9;136(2):258. doi: 10.1182/blood.2020006057. PMID: 32645172.
    15. Lyapichev KA, You MJ, Vega F, Solis LM, Medeiros LJ. Classic Hodgkin lymphoma and Castleman disease: an entity appears to be emerging. Virchows Arch. 2020 Sep;477(3):437-444. doi: 10.1007/s00428-020-02788-7. Epub 2020 Mar 9. PMID: 32152665.
    16. Lyapichev KA, Medeiros LJ, Clemens MW, Ferrufino-Schmidt MC, Marques-Piubelli ML, Chai SM, Evans MG, Khoury JD, Miranda RN. Reconsideration of the first recognition of breast implant-associated anaplastic large cell lymphoma: A critical review of the literature. Ann Diagn Pathol. 2020 Apr;45:151474. doi: 10.1016/j.anndiagpath.2020.151474. Epub 2020 Jan 29. PMID: 32028122.
    17. Sukswai N, Jung HR, Amr SS, Ng SB, Sheikh SS, Lyapichev KA, El Hussein S, Loghavi S, Agbay RLMC, Miranda RN, Medeiros LJ, Khoury JD. Immunopathology of Kikuchi-Fujimoto Disease: A reappraisal using novel immunohistochemistry combinations. Histopathology. 2020 Aug;77(2):262-274. doi: 10.1111/his.14050. Epub 2020 Jul 30. PMID: 31854007.
    18. Sukswai N, Lyapichev KA, Khoury JD, Medeiros LJ. (2019) Diffuse large B-cell lymphoma variants: an update. Pathology. 2020 Jan;52(1):53-67. doi: 10.1016/j.pathol.2019.08.013. Epub 2019 Nov 15. PMID: 31735345.
    19. Lyapichev KA, Sukswai N, Strati P, Iyer SP, Medeiros LJ, Miranda RN. Unicentric Castleman disease, hyaline vascular variant, stromal rich, with increased plasma cells and a high level of serum IL-6: Raising the diagnostic and therapeutic issues. Ann Diagn Pathol. 2019 Dec;43:151398. doi: 10.1016/j.anndiagpath.2019.08.002. Epub 2019 Aug 3. PMID: 31630065.
    20. Lyapichev KA, Pina-Oviedo S, Medeiros LJ, Evans MG, Liu H, Miranda AR, et al. A proposal for pathologic processing of breast implant capsules in patients with suspected breast implant anaplastic large cell lymphoma. Mod Pathol. 2020 Mar;33(3):367-379. doi: 10.1038/s41379-019-0337-2. Epub 2019 Aug 5. PMID: 31383966; PMCID: PMC7489290.
    21. Lyapichev KA, Kurt H, Sukswai N, Konoplev S, Bueso-Ramos CE, Khoury JD, et al. Chronic lymphocytic leukemia with plasmacytic differentiation. Ann Hematol. 2019 Oct;98(10):2437-2438. doi: 10.1007/s00277-019-03784-x. Epub 2019 Aug 26. PMID: 31451834.
    22. Lyapichev KA, Sukswai N, Wang XI, Khoury JD, Medeiros LJ. Hydroa Vacciniforme-Like Lymphoproliferative Disorder With Progression to EBV+ Cytotoxic Peripheral T-Cell Lymphoma. Am J Dermatopathol. 2020 Sep;42(9):714-716. doi: 10.1097/DAD.0000000000001494. PMID: 31313696.
    23. Sukswai N, Aung PP, Yin CC, Li S, Wang W, Wang SA, Ortega V, Lyapichev KA, Nagarajan P, Alfattal R, Angelova E, Tang Z, Loghavi S, Kanagal-Shamanna R, Miranda RN, Pemmaraju N, Bhalla K, Konopleva M, Medeiros LJ, Khoury JD. Dual Expression of TCF4 and CD123 Is Highly Sensitive and Specific For Blastic Plasmacytoid Dendritic Cell Neoplasm. Am J Surg Pathol. 2019 Oct;43(10):1429-1437. doi: 10.1097/PAS.0000000000001316. PMID: 31261288.
    24. Lyapichev KA, Sukswai N, Konoplev S, Khoury JD. Blastic plasmacytoid dendritic cell neoplasm with unusual lymphoid features and macrovacuoles. Ann Hematol. 2019 Sep;98(9):2221-2222. doi: 10.1007/s00277-019-03675-1. Epub 2019 Apr 7. PMID: 30955062.
    25. Sukswai N, Lyapichev KA, Medeiros LJ, Khoury JD. Unusual case of human herpesvirus 8-positive large B-cell lymphoma associated with Castleman disease. lin Case Rep. 2019 Feb 7;7(3):587-588. doi: 10.1002/ccr3.2015. PMID: 30899504; PMCID: PMC6406148.
    26. 26) Lyapichev KA, You MJ. Unusual presentation of classic Hodgkin lymphoma. Blood. 2019 Jan 31;133(5):502. doi: 10.1182/blood-2018-10-878058. PMID: 30705049.
    27. Lyapichev KA, Li S. Extensive Kaposi sarcoma infiltration in bone marrow in a patient with HIV. Blood. 2018 Dec 6;132(23):2525. doi: 10.1182/blood-2018-09-872994. PMID: 30523127.
    28. Lyapichev KA, Chapman JR, Iakymenko O, Ikpatt OF, Teomete U, Sanchez SP, et al. Bone Marrow-Liver-Spleen Type of Large B-Cell Lymphoma Associated with Hemophagocytic Syndrome: A Rare Aggressive Extranodal Lymphoma. Case Rep Hematol. 2017;2017:8496978. doi: 10.1155/2017/8496978. Epub 2017 Aug 1. PMID: 28835859; PMCID: PMC5556984.