Lynn Soong, MD, PhD

Lynn Soong, MD, PhD

Departments of Microbiology/Immunology and Pathology
Associate Director, Institute for Human Infections and Immunity
Program Director, NIAID T35 Infectious Diseases and Inflammatory Disorders Training Program
Member, Center for Biodefense & Emerging Infectious Diseases
Member, Sealy Center for Vaccine Development

Phone: (409) 772-8149

Lynn Soong, MD, PhD

  • Dr. Soong’s research focuses on New World cutaneous, mucosal and visceral leishmaniasis. Using mouse and hamster infection models, her team wants to understand how innate and adaptive immune responses against Leishmania parasites are regulated, which host- and parasite-derived factors are responsible for disease pathogenesis, and which molecules can be incorporated in the vaccine regimen. Special focus is placed on the impact of parasite infection on the functions of dendritic cells and macrophages, as well as on the role of regulatory T cells and Th cells in the outcome of infection. New lines of research include Leishmania proteomics and biochemistry, host cell signaling during the infection, susceptibility variants for mucosal leishmaniasis in Peru. In addition, she has active collaborations with other scientists on sand fly transmission of Leishmania, tick-transmitted bacteria infection, and mosquito-transmitted viral infection.
  • PhD University of Georgia, Athens, Georgia Zoology (Immunoparasitology) 1992
    MS Shanghai Medical University, China Virology 1986
    MD Shanghai Medical University, China Medicine 1983
  • 2005 Researcher of the Year, Department of Pathology, University of Texas Medical Branch
    2000 American Society of Tropical Medicine and Hygiene Travel Award to
    Oxford, UK
    2000 American Association of Immunologists (AAI) Travel Award
    1994 James Hudson Brown-Alexander B. Coxe Fellowship, Yale Medical School
  • 1999-Present Ad hoc reviewer in NIAID study sections: Tropical Medicine & Parasitol. (3), Virology (1), Microbiology & Infectious Disease Research Committee (1), Vaccines Against Microbial Diseases (1), American Heart Association (1)
    2000 Ad hoc reviewer in Am. J Trop. Med. & Hyg.; J Exp. Parasitol.; Clin. Inf. Dis.; J Inf. Dis.; Infect & Immun; J Immunol.; Vaccine; Trends Parasitol.; Microbes & Infect; Vaccine; J Exp. Med.
    2003-2007 Member in the NIAID Pathogenic Eukaryotes (PTHE) study section
    2000-2003 AAI Committee for Women’s Statusl
    1. Vasquez, R. E., L. Xin, and L. Soong. Effects of CXCL10 on dendritic cell and CD4+ T cell functions during Leishmania amazonensis infection. Infect Immun. 76:161-169, 2008.
    2. Wanasen, N., L. Xin, and L. Soong. The role of B cells and antibody in pathogenesis of Leishmania amazonensis infection in mice. Int. J. Parasitology. 38:414-429, 2008.
    3. Wanasen, N. and L. Soong. L-arginine metabolism and its interaction with the host immune system during Leishmania infection. Immunol. Res. 41:15-25, 2008.
    4. Soong, L. Modulation of dendritic cell function by Leishmania parasites. J. Immunol., 180:4355-4360, 2008.
    5. Vargas-Inchaustegui, D., L. Xin, and L. Soong. Leishmania braziliensis infection induces dendritic cell activation, ISG15 transcription and the generation of protective immune responses. J. Immunol., 180:7537-7545, 2008.
    6. Li, G.-Y., T. Duan, X.-Y. Wu, R. B. Tesh, L. Soong, and S.-Y. Xiao. Yellow Fever virus infection in hamsters: the relationship between cytokine expression and organ pathology. Int. J. Clin. Exp. Pathol. 1:169-179, 2008.
    7. Hong, B.X. and L. Soong. Identification and enzymatic activities of four protein disulfide isomerase (PDI) isoforms of Leishmania amazonensis. Parasitol. Res. 102:437-446, 2008.
    8. Xin, L., L. Kui, and L. Soong.  Down-regulation of dendritic cell signaling pathways by Leishmania amastigotes. Mol. Immunol. 45:3371-3382, 2008.
    9. Hernández Sanabria, M. X., D. Vargas-Inchaustegui, and L. Soong. The role of natural killer cells in modulating dendritic cell responses to Leishmania amazonensis infection. Infect. Immun. 76:5100-5109, 2008. 
    10. Marin-Villa, D. Vargas-Inchaustegui, M., M. J. Soares, G. Este, C. Pirmez, T. Nakamura, M. A. V. Santos, L. Soong, Y. M. Traub-Cseko. Leishmania pifanoi amastigote-specific lysosomal cysteine proteinase Lpcys2 C-terminal extension: a putative function in macrophage invasion.  Mol. & Biochem Parasitology. 162:52-59, 2008.
    11. Jordan, J. M., M. E. Woods, L. Soong, and D. H. Walker. Rickettsiae stimulate dendritic cells through TLR4, leading to an enhanced NK cell activation in vivo. J. Infectious Diseases, 199:236-42, 2009.
    12. Vargas-Inchaustegui, D., W. Tai, L.-J. Xin, A. E. Hogg, D. Corry, and L. Soong. Distinct roles of MyD88 and TLR2 during Leishmania braziliensis infection in mice. Infect Immun, 77:2948-56, 2009.
    13. Wanderley, J. L. M., L. H. P. da Silva, P. Deolindo,  L. Soong, V. M. Borges, D. B. Prates, A. P. A. de Souza, A. Barral, J. M. F. Balanco, M. T. C. Nascimento, E. M. Saraiva, and M. A. Barcinski. Cooperation between apoptotic and viable promastigotes enhances the pathogenesis of leishmaniasis. PLosOne, 4(5):e5733, 2009.
    14. Liu, T.*, L. Soong*, G. Liu, R. Konig, A. K. Chopra. (*equal contribution) The development of CD4+CD25+CD44+ regulatory T cells in the thymus. Biology Direct. In press, 2009

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