M. Firoze Khan, PhD

M. Firoze Khan, PhD
Professor

Department of Pathology

Member, Gulf Coast Center for Precision Environmental Health 

Member, Sealy Center for Environmental Health & Medicine

Member, Sealy Center on Lung Disease, Inflammation and Remodeling

Fellow, Center for Interdisciplinary Research in Women’s Health



Phone: (409) 772-6881
Email: mfkhan@utmb.edu

    • Environmental agents and autoimmunity/autoimmune diseases
    • Oxidative stress and systemic lupus erythematosus/autoimmune hepatitis
    • Role of microbiome in inflammation and autoimmune diseases
    • Molecular mechanisms of aromatic amine-induced aberrant cell cycle regulation/immunotoxicity
    • Biomarkers of chemical exposure
  • BS Aligarh Muslim University, Aligarh, India Chemistry 1976
    MS Aligarh Muslim University, Aligarh, India Biochemistry 1978
    MPhil Aligarh Muslim University, Aligarh, India Biochemistry 1980
    PhD Aligarh Muslim University, Aligarh, India Biochemistry 1983
  • 2024Vos Lifetime Career Achievement Award in Immunotoxicology, Society of Toxicology
    2020Associate Editor, Frontiers in Immunology
    2020Associate Editor, Frontiers in Toxicology
    2019"Researcher of the Year", Department of Pathology, UTMB, Galveston, TX
    2019Senior Editor, Journal of Inflammation
    2018"Outstanding Senior Immunotoxicologist" award, Society of Toxicology
    2015Senior Toxicologist Award, ASIOA-SOT, Society of Toxicology, San Diego, CA
    2014Chairperson of a platform session on "Hypersensitivity and Autoimmunity", 53rd Annual Meeting of Society of Toxicology, Phoenix, AZ, March, 2014
    2012 Associate Editor, Toxicology and Applied Pharmacology
    2010Member, College of CSR Reviewers (NIH)
    2007"Researcher of the Year", Department of Pathology, UTMB, Galveston, TX
    1998Young Scientist Award, Association of Scientists of Indian Origin in America, San Francisco, CA
  • 1994-Present Society of Toxicology (Elected)
    1996-Present American Society for Pharmacology and Experimental Therapeutics (Elected)
    1997-2007 Society for Experimental Biology and Medicine (SEBM)
    1997-2013 American Chemical Society (ACS)
    2003-Present Society for Free Radical Biology and Medicine (SFRBM)

  • Khan MF, Kaphalia BS, Prabhakar BS, Kanz MF, Ansari GAS. Trichloroethene-induced autoimmune response in female MRL+/+ mice. Toxicol Appl Pharmacol 134:155-160, 1995.

    Khan MF, Gu, Y, Alcock NW, Boor PJ, Ansari GAS. Oxidative stress in splenotoxicity of aniline. Fundam Appl Toxicol 35:22-30, 1997.

    Khan MF, Green, SM, Ansari GAS, Boor PJ. Phenylhydroxylamine: Role in aniline-associated splenic oxidative stress and induction of subendocardial necrosis in rats. Toxicol Sci 42:64-71, 1998.

    Khan, MF, Wu X, Boor PJ, Ansari GAS. Oxidative modification of proteins and lipids in aniline-induced splenic toxicity. Toxicol Sci 48:134-140, 1999.

    Khan, MF, Wu X, Ansari GAS. Anti-malondialdehyde antibodies in MR +/+ mice treated with trichloroethene and dichloroacetyl chloride: Possible role of lipid peroxidation in autoimmunity. Toxico Appl Pharmacol 170:88-92, 2001.

    Wang G, Konig R, Ansari GAS, Khan MF. Lipid peroxidation-derived aldehyde-protein adducts contribute to trichloroethene-mediated autoimmunity via CD4+T cell activation. Free Radic Biol Med 44:1475-1482, 2008.

    Wang G, Ma H, Wang J, Khan MF. Nitration and carbonylation of proteins in MRL+/+ mice exposed to trichloroethene: Possible role of protein oxidation in autoimmunity. Toxicol Appl Pharmacol 237:188-195, 2009.

    Wang G, Ma H, Boor PJ, Sadagopa Ramanujam VM, Ansari GAS, Khan MF.  Up-regulation of heme oxygenase-1 in rat spleen following aniline exposure. Free Radic Biol Med 48:513-518, 2010.

    Wang G, Pierangeli S, Papalardo E, Ansari GAS, Khan MF. Markers of oxidative and nitrosative stress in systemic lupus erythematosus: Correlation with disease activity. Arthritis Rheum 62:2064-2072, 2010.

    Wang G, Wang J, Fan X, Ansari GAS, Khan MF. Oxidative stress contributes to trichloroethene-mediated autoimmunity: Involvement of Th17 cells. Toxicology 292:113-122, 2012.

    Wang G, Wang J, Ma H, Ansari GAS, Khan MF. N-Acetylcysteine protects against trichloroethene-mediated autoimmunity by attenuating oxidative stress. Toxicol Appl Pharmacol 273:189-195, 2013.

    Wang G, Wakamiya M, Wang J, Ansari, GAS, Khan MF. iNOS null MRL +/+ mice show attenuation of trichloroethene-mediated autoimmunity: contribution of reactive nitrogen species and lipid-derived reactive Aldehydes. Free Radic Biol Med 89:770-776, 2015.

    Wang G, Pierangeli SS, Willis R, Gonzalez EB, Petri M, Khan MF.  Significance of lipid-derived reactive aldehyde-specific immune complexes in systemic lupus erythematosus.  PLoS ONE 11: e0164739, 1-15, 2016.

    Wang G, Ma H, Khan MF.  Role of poly(ADP-ribose)polymerase-1 activation and apoptosis in trichloroethene-mediated autoimmunity response. Toxicol Appl Pharmacol 362:28-34, 2019.

    Wang H, Wang G, Liang Y, Xiaotang D, Boor PJ, Sun J, Khan MF. Redox regulation of hepatic NLRP3 inflammasome activation and immune dysregulation in trichloroethene-mediated autoimmunity. Free Radic Biol Med 143:223-231, 2019.

    Wang G, Wakamiya M, Wang J, Ansari GAS, Khan MF. Cytochrome P450 2E1-deficient MRL+/+ mice are less susceptible to trichloroethene-mediated autoimmunity: Involvement of oxidative stress-responsive signaling pathways. Free Radic Biol Med 143:324-330, 2019.

    Khan MF, Wang H.  Environmental exposures and autoimmune diseases: Contribution of gut microbiome. Front Immunol 10:3094, 2020.

    Banerjee N, Wang H, Wang G, Khan MF.  Enhancing the Nrf2 antioxidant signaling provides protection against trichloroethene-mediated inflammation and autoimmune response. Toxicol Sci 175:64-74, 2020.

    Wang H, Wang G, Banerjee N, Liang Y, Xiaotang D, Boor PJ, Hoffman KL, Khan MF. Aberrant gut microbiome contributes to intestinal oxidative stress, barrier dysfunction, inflammation and systemic autoimmune responses in MRL/lpr mice. Front Immunol 12:651191, 2021.

    Banerjee N, Wang H, Wang G, Boor P, Khan MF.  Redox-sensitive Nrf2 and MAPK signaling pathways contribute to trichloroethene-mediated autoimmune disease progression. Toxicology  457:152804, 2021.

    Wang H, Banerjee N, Liang Y, Wang G, Hoffman, KL, Khan MF.  Gut microbiome-host interactions in driving environmental pollutant trichloroethene-mediated autoimmunity. Toxicol Appl Pharmacol 424:115597, 2021. 

    Banerjee N, Wang H, Wang G, Boor P, Khan MF.  Differential expression of miRNAs in TCE-mediated inflammatory/autoimmune response and its modulation by sulforaphane: Delineating the role of miRNA-21 and miRNA-690. Front Immunol 13:868539, 2022.

    Wang H, Wang G, Banerjee, Khan MF. Autophagy dysregulation in trichloroethene-mediated inflammation and autoimmunity. Toxicology 487:153468, 2023.

    Wang H, Yuejin L, Boor PJ, Khanipov K, Zhang Y, Yu X, Ambati CSR, Putluri N, Khan MF.  Protective role of dietary short chain fatty acid propionate against autoimmune responses and pathology of systemic lupus erythematosus in MRL-lpr mice. J Nutrition 155:3116-3127,2025.

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