M. Firoze Khan, PhD

M. Firoze Khan, PhD

Department of Pathology
Member, NIEHS Center
Member, Sealy Center for Environmental Health & Medicine

Phone: (409) 772-6881
Email: mfkhan@utmb.edu

M. Firoze Khan, PhD

    • Oxidative stress and autoimmune diseases
    • Chemical-induced autoimmunity
    • Molecular mechanisms of splenic toxicity of aromatic amines
    • Biomarkers of chemical exposure
  • BS Aligarh Muslim University, Aligarh, India Chemistry 1976
    MS Aligarh Muslim University, Aligarh, India Biochemistry 1978
    MPhil Aligarh Muslim University, Aligarh, India Biochemistry 1980
    PhD Aligarh Muslim University, Aligarh, India Biochemistry 1983
  • 2015 Senior Toxicologist Award, ASIOA-SOT, Society of Toxicology, San Diego, CA
    2014 Chairperson of a platform session on "Hypersensitivity and Autoimmunity", 53rd Annual Meeting of Society of Toxicology, Phoenix, AZ, March, 2014
    2012 - present Associate Editor, Toxicology and Applied Pharmacology
    2010 Member, College of CSR Reviewers (NIH)
    2007 "Researcher of the Year", Department of Pathology, UTMB, Galveston, TX
    1998 Young Scientist Award, Association of Scientists of Indian Origin in America, San Francisco, CA
  • 1994-Present Society of Toxicology (Elected)
    1996-Present American Society for Pharmacology and Experimental Therapeutics (Elected)
    1997-2007 Society for Experimental Biology and Medicine (SEBM)
    1997-2013 American Chemical Society (ACS)
    2003-Present Society for Free Radical Biology and Medicine (SFRBM)
    1. Khan MF, Kaphalia BS, Prabhakar BS, Kanz MF, Ansari GAS. Trichloroethene-induced autoimmune response in female MRL+/+ mice. Toxicol Appl Pharmacol 134:155-160, 1995.
    2. Khan MF, Gu, Y, Alcock NW, Boor PJ, Ansari GAS. Oxidative stress in splenotoxicity of aniline. Fundam Appl Toxicol 35:22-30, 1997.
    3. Khan MF, Green, SM, Ansari GAS, Boor PJ. Phenylhydroxylamine: Role in aniline-associated splenic oxidative stress and induction of subendocardial necrosis in rats. Toxicol Sci 42:64-71, 1998.
    4. Khan MF, Wu X, Boor PJ, Ansari GAS. Oxidative modification of proteins and lipids in aniline-induced splenic toxicity. Toxicol Sci 48:134-140, 1999.
    5. Khan MF, Wu X, Ansari GAS. Anti-malondialdehyde antibodies in MR +/+ mice treated with trichloroethene and dichloroacetyl chloride:Possible role of lipid peroxidation in autoimmunity. Toxico Appl Pharmacol 170:88-92, 2001.
    6. Wang J, Kannan S, Li H, Khan MF. Cytokine gene expression and activation of NF-kB in aniline-induced splenic toxicity. Toxicol Appl Pharmacol 203:36-44, 2005.
    7. Khan MF, Kannan S, Wang J. Activation of transcription factor AP-1 and mitogen-activated protein kinases in aniline-induced splenic toxicity. Toxicol Appl Pharmacol 210:86-93, 2006.
    8. Wang G, Cai P, Ansari GAS, Khan MF. Oxidative and nitrosative stress in intrichloroethene-mediated autoimmune response. Toxicology 229:186-193, 2007.
    9. Wang G, Konig R, Ansari GAS, Khan MF. Lipid peroxidation-derived aldehyde-protein adducts contribute to trichloroethene-mediated autoimmunity via CD4+Tcell activation. Free Radic Biol Med 44:1475-1482, 2008.
    10. Wang J, Wang G, Ansari GAS, Khan MF. Activation of oxidative stress-responsive signaling pathways in early splenotoxic response of aniline. Toxicol Appl Pharmacol 230:227-234, 2008.
    11. Wang G, Ma H, Wang J, Khan MF. Nitration and carbonylation of proteins in MRL+/+ mice exposed to trichloroethene: Possible role of protein oxidation in autoimmunity. Toxicol Appl Pharmacol 237:188-195, 2009.
    12. Wang G, Ma H, Boor PJ, Sadagopa Ramanujam VM, Ansari GAS, Khan MF.Up-regulation of heme oxygenase-1 in rat spleen following aniline exposure. Free Radic Biol Med 48:513-518, 2010.
    1. Wang G, Pierangeli S, Papalardo E, Ansari GAS, Khan MF. Markers of oxidative and nitrosative stress in systemic lupus erythematosus: Correlation with disease activity. Arthritis Rheum 62:2064-2072, 2010.
    1. Wang J, Wang G, Ma H, Khan MF. Enhanced expression of cyclins and cyclin-dependent kinases in aniline-induced cell proliferation in rat spleen. Toxicol Appl Pharmacol 250:213-220, 2011.
    1. Wang G, Wang J, Fan X, Ansari GAS, Khan MF. Oxidative stress contributes to trichloroethene-mediated autoimmunity: Involvement of Th17 cells. Toxicology 292:113-122, 2012.
    1. Kondraganti S,Konig R, Boor PJ,Khan S,Kaphalia BS, Khan MF, Ansari GAS.  Mechanistic evaluation of TCE-mediated autoimmune hepatitis-like disease in female MRL+/+ mice. The Open Toxicol J 5:1-10, 2012.
    1. Wang G, Li H, Khan MF. Differential modification of proteins in MRL+/+ and MRL/lpr mice: Increased formation of lipid peroxidation derived aldehyde-protein adducts may contribute to accelerated onset of autoimmune response. Free Radic Res 46:1472-1481, 2012.
    1. Wang G, Wang J, Ma H, Ansari GAS, Khan MF. N-Acetylcysteine protects against trichloroethene-mediated autoimmunity by attenuating oxidative stress. Toxicol Appl Pharmacol 273:189-195, 2013.
    1. Wang G, Wang J, Luo X, Ansari GAS, Khan MF. Nitrosative stress and nitrated proteins in trichloroethene-mediated autoimmunity. PLoS ONE 9:1-10, e98660, 2014.
    1. Wang J, Wang G, Khan MF. Disorder of G2-M checkpoint control in aniline-induced cell proliferation in rat spleen. PLoS ONE 10:e0131457, 2015.

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